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Immunosuppression and Neuroinflammation in Stroke Pathobiology

Jiang Q, Stone CR, Elkin K, Geng X, Ding Y

  • KMID: 2515810
  • Exp Neurobiol.
  • 2021 Apr;30(2):101-112.
  • doi: 10.5607/en20033
Over the preceding decades, there have been substantial advances in our knowledge of the pathophysiology of stroke. One such advance has been an increased understanding of the multifarious crosstalk in...
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Effects of Lactobacillus acidophilus HY7032 and Lactobacillus reuteri HY7506 isolated from dog feces on welfare and hair in companion dogs

Lee HJ, Lee SW

Precise combinations of probiotics can be useful in dog nutrition, treatment and care. Also, host specificity must be considered in order to increase the effectiveness of probiotics. In this study,...
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Understanding the Host Innate Immune Responses against SARS-CoV-2 Infection and COVID-19 Pathogenesis

Kang YW, Park S, Lee KJ, Moon D, Kim YM, Lee SW

The emergence of a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has become a significant health concern worldwide. Undoubtedly, a better understanding of the innate and adaptive immune...
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Biomarkers and Associated Immune Mechanisms for Early Detection and Therapeutic Management of Sepsis

Trzeciak A, Pietropaoli AP, Kim M

Sepsis is conceptually defined as life-threatening organ dysfunction that is caused by a dysregulated host response to infection. Although there has been significant advancement in recent decades in defining and...
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Immune Response to Fungal Pathogens

Kim SM, Park CO

Fungi rarely cause disease in individuals with normal immunity. However, fungi present in the normal biota of the skin, mucous membranes, intestinal tract, and fungi in the environment that are...
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Current Understanding on the Metabolism of Neutrophils

Jeon JH, Hong CW, Kim EY, Lee JM

Neutrophils are innate immune cells that constitute the first line of defense against invading pathogens. Due to this characteristic, they are exposed to diverse immunological environments wherein sources for nutrients...
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Crosstalk between the Producers and Immune Targets of IL-9

Do-Thi VA, Lee JO, Lee H, Kim YS

IL-9 has been reported to play dual roles in the pathogenesis of autoimmune disorders and cancers. The collaboration of IL-9 with microenvironmental factors including the broader cytokine milieu and other...
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The Interaction between Joint Inflammation and Cartilage Repair

van der Kraan PM

BACKGROUND: Articular cartilage lesions occur frequently but unfortunately damaged cartilage has a very limited intrinsic repair capacity. Therefore, there is a high need to develop technology that makes cartilage repair...
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Potential Roles of Innate Immune Chemokine and Cytokine Network on Lipopolysaccharide-Based Therapeutic Approach in Ovarian Cancer

Ignacio RM, Lee ES, Son DS

Ovarian cancer (OC), the deadliest gynecological cancer, results in poor overall survival, urgently requiring a novel therapeutic approach. As cumulative exposures to endotoxins decreased OC risk epidemiologically, we evaluated if...
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Effector Pathways of Toll-like Receptor-inducible Innate Immune Responses in Macrophages

Jo EK, Suh HW, Park JK

Toll-like receptors (TLR) are well-characterized pattern recognition receptors that can recognize and respond to diverse pathogen-associated or danger-associated molecular patterns during infection. TLR signaling in macrophages triggers in the intracellular...
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The Interplay between Host Immunity and Respiratory Viral Infection in Asthma Exacerbation

Hossain FM, Choi JY, Uyangaa E, Park SO, Eo SK

Asthma is one of the most common and chronic diseases characterized by multidimensional immune responses along with poor prognosis and severity. The heterogeneous nature of asthma may be attributed to...
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A Salmonella Typhi ghost induced by the E gene of phage φX174 stimulates dendritic cells and efficiently activates the adaptive immune response

Won G, Eo SK, Park SY, Hur J, Lee JH

Previously, we genetically engineered a Salmonella Typhi bacterial ghost (STG) as a novel inactivated vaccine candidate against typhoid fever. The underlying mechanism employed by the ghost in stimulating the adaptive...
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Characteristics and Immunological Roles of Surface Layer Proteins in Clostridium difficile

Mori N, Takahashi

Clostridium difficile is a major causative agent of antibiotic-associated diarrhea and has become the most common pathogen of healthcare-associated infection worldwide. The pathogenesis of C. difficile infection (CDI) is mediated...
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Can Controlling Endoplasmic Reticulum Dysfunction Treat Allergic Inflammation in Severe Asthma With Fungal Sensitization?

Jeong JS, Kim SR, Lee YC

Severe asthma is a heterogeneous disease entity to which diverse cellular components and pathogenetic mechanisms contribute. Current asthma therapies, including new biologic agents, are mainly targeting T helper type 2...
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Sex hormones alter the response of Toll-like receptor 3 to its specific ligand in fallopian tube epithelial cells

Zandieh Z, Amjadi F, Vakilian H, Aflatoonian K, Amirchaghmaghi E, Fazeli A, Aflatoonian R

OBJECTIVE: The fallopian tubes play a critical role in the early events of fertilization. The rapid innate immune defense is an important part of the fallopian tubes. Toll-like receptor 3...
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Differential Hrd1 Expression and B-Cell Accumulation in Eosinophilic and Non-eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Chen K, Han M, Tang M, Xie Y, Lai Y, Hu X, Zhang J, Yang J, Li H

PURPOSE: Hrd1 has recently emerged as a critical regulator of B-cells in autoimmune diseases. However, its role in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) remains largely unexplored....
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Decreased CRTH2 Expression and Response to Allergen Re-stimulation on Innate Lymphoid Cells in Patients With Allergen-Specific Immunotherapy

Mitthamsiri W, Pradubpongsa P, Sangasapaviliya A, Boonpiyathad T

PURPOSE: Group 2 innate lymphoid cells (ILC2s) have been implicated in the pathogenesis of allergic disease. However, the effect of allergen-specific immunotherapy (AIT) on ILCs remains to be clarified. The...
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Innate immune response of bovine mammary epithelial cells to Mycoplasma bovis

Gondaira S, Higuchi H, Iwano H, Nishi K, Nebu T, Nakajima K, Nagahata H

Mycoplasma spp. are contagious bacteria, and mycoplasmal mastitis is a serious productivity problem on dairy farms. Bovine mammary epithelial cells (bMECs) have an important role in the elimination of pathogens,...
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New Discoveries Regarding Endotypes of Chronic Rhinosinusitis with Nasal Polyp

Yang JH, Kim DK

Chronic rhinosinusitis (CRS) is a common chronic inflammatory disease of the nasal and paranasal mucosa and it usually affects substantial impaired quality of life. CRS is a highly heterogeneous disease...
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Immunologic Mechanism of Ischemia Reperfusion Injury in Transplantation

Lee JS

Ischemia-reperfusion injury (IRI) is an inevitable consequence of organ transplantation that has major consequences for graft-and patient survival. During transplantation procedures, allografts are exposed to various periods of complete ischemia....
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