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Analysis of Essential oil, Quantification of Six Glycosides, and Nitric Oxide Synthase Inhibition Activity in Caryopteris incana

Nugroho A, Lee SK, Kim D, Choi JS, Park KS, Song BM, Park HJ

Caryopteris incana (Verbenaceae) has been used to treat cough, arthritis, and eczema in Oriental medicine. The two fractions (CHCl₃- and BuOH fractions) and the essential oil of the plant material...
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Protective effect of water extract of guibi-tang against pulmonary inflammation induced by cigarette smoke and lipopolysaccharide

Shin NR, Jung TY, Seo CS, Park SW, Ko JW, Kim JC, Shin IS

Water extract of guibi-tang (GB), a traditional Chinese, Japanese, and Korean herbal medicine, is used to treat memory impairment, insomnia, and peptic ulcers. The aim of this study was to...
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Artemisia argyi attenuates airway inflammation in lipopolysaccharide induced acute lung injury model

Shin NR, Park SH, Ko JW, Ryu HW, Jeong SH, Kim JC, Shin DH, Lee HS, Shin IS

Artemisia argyi is used as a health supplement, tea, and food source in Korea. This study aimed to evaluate the effect of Artemisia argyi (AA) and its active compound, dehydromatricarin...
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Neuroprotection of Dexmedetomidine against Cerebral Ischemia-Reperfusion Injury in Rats: Involved in Inhibition of NF-κB and Inflammation Response

Wang L, Liu H, Zhang L, Wang G, Zhang M, Yu Y

Dexmedetomidine is an α2-adrenergic receptor agonist that exhibits a protective effect on ischemia-reperfusion injury of the heart, kidney, and other organs. In the present study, we examined the neuroprotective action...
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Inhibitory Effect of a Sesquiterpene from Artemisia iwayomogi on Expression of Inducible Nitric Oxide Synthase by Suppression of I-κBα Degradation in LPS-stimulated RAW 264.7 Cells

Kim NY, Koh HJ, Li H, Lee HJ, Ryu JH

A sesquiterpene was purified from Artemisia iwayomogi methanolic extract during the course of searching anti-inflammatory principle from medicinal plants. A sesquiterpene identified as armefolin inhibited the production of nitric oxide...
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The Potential Role of Nitric Oxide in Halting Cancer Progression Through Chemoprevention

Vahora H, Khan MA, Alalami U, Hussain A

Nitric oxide (NO) in general plays a beneficial physiological role as a vasorelaxant and the role of NO is decided by its concentration present in physiological environments. NO either facilitates...
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Pathological Lesions and Inducible Nitric Oxide Synthase Expressions in the Liver of Mice Experimentally Infected with Clonorchis sinensis

Yang QL, Shen JQ, Xue Y, Cheng XB, Jiang ZH, Yang YC, Chen YD, Zhou XN

The nitric oxide (NO) formation and intrinsic nitrosation may be involved in the possible mechanisms of liver fluke-associated carcinogenesis. We still do not know much about the responses of inducible...
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Alternatively activated M2 macrophages increase in early stages of experimental autoimmune myocarditis in Lewis rats

Oh H, Ahn M, Matsumoto , Taekyun S

  • KMID: 1790569
  • Korean J Vet Res.
  • 2013 Dec;53(4):225-230.
To better understand the role of macrophages in early stages of experimental autoimmune myocarditis (EAM), we compared the expression of inducible nitric oxide synthase (iNOS) and arginase-1, markers for classically...
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Mitochondrial dysfunction and activation of iNOS are responsible for the palmitate-induced decrease in adiponectin synthesis in 3T3L1 adipocytes

Jeon MJ, Leem J, Ko MS, Jang JE, Park HS, Kim HS, Kim M, Kim EH, Yoo HJ, Lee CH, Park IS, Lee KU, Koh EH

  • KMID: 1389736
  • Exp Mol Med.
  • 2012 Sep;44(9):562-570.
Mitochondrial dysfunction and endoplasmic reticulum (ER) stress are considered the key determinants of insulin resistance. Impaired mitochondrial function in obese animals was shown to induce the ER stress response, resulting...
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Anti-Inflammatory Effect of Houttuynia Cordata Thunb in Activated Raw 264.7 Cells Activated with Lipopolysaccharide and Interferon Gamma

  • KMID: 2299480
  • Korean J Asthma Allergy Clin Immunol.
  • 2012 Mar;32(1):43-50.
BACKGROUND: Houttuynia cordata has long been used in traditional oriental medicine for the treatment of inflammatory disease. In the present study, we investigated the anti-inflammatory effect of Houttuynia cordata extracts...
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Epigallocatechin-3-gallate Regulates Inducible Nitric Oxide Synthase Expression in Human Umbilical Vein Endothelial Cells

Ahn HY, Kim CH

Inducible nitric oxide synthase (iNOS) is a main enzyme producing nitric oxide during inflammation and thus contributes to the initiation and development of inflammatory cardiovascular diseases such as atherosclerosis. Epigallocatechin-3-gallate...
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The effect of heat shock protein 70 on inducible nitric oxide synthase during sepsis in rats

Lee YK, Ahn Y, Leem DH, Baek JA, Ko SO, Shin HK

  • KMID: 2328498
  • J Korean Assoc Oral Maxillofac Surg.
  • 2010 Oct;36(5):346-352.
INTRODUCTION: Heat shock protein70 (HSP70) is a highly conserved family of proteins produced after a variety of stresses. Many studies reported that the overexpression of HSP70 can improve the prognosis...
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Induction of Inducible Nitric Oxide Synthase Expression by Manganese in C6 Glioma Cells

Yu GI, Lee DH, Chung IS, Lee MY, Shin DH

  • KMID: 1475121
  • Korean J Occup Environ Med.
  • 2009 Sep;21(3):259-266.
OBJECTIVE: It is well established that manganese neurotoxicity is associated with clinical symptoms similar to those of idiopathic Parkinson's disease. Recent research has shown that the exposure to manganese (MnCl2)...
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Anti-Inflammatory Effect of Near-Infrared Irradiated Cell Culture Media

Kim SG, Shin IH, Choi CH, Choe JY

BACKGROUND: Near-infrared light (NIR, 0.8-1.5 micrometer light) has been used in therapeutic devices for various injuries such as infected, ischemic and hypoxic wound. NIR-emitting technology has been developed recently in...
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Deficiency of iNOS Does Not Prevent Isoproterenol-induced Cardiac Hypertrophy in Mice

Cha HN, Hong GR, Kim YW, Kim JY, Dan JM, Park SY

We investigated whether deficiency of inducible nitric oxide synthase (iNOS) could prevent isoproterenol-induced cardiac hypertrophy in iNOS knockout (KO) mice. Isoproterenol was continuously infused subcutaneously (15 mg/kg/day) using an osmotic...
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Effects of Armeniacae Semen and Amygdalin on the Lipopolysaccaride-induced Prostaglandin E2 Synthesis and Nitric Oxide Production in Mouse BV2 Microglial Cells

Jung HJ, Kim YS, Shin MS, Kim CJ, Kim YS

Armeniacae semen has been used in traditional medicine for the treatment of pain and inflammatory diseases. Amygdalin is the major compound of Armeniacae semen, and it is used for treatment...
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The Change of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in the Gastric Mucosa One Year after Eradication of Helicobacter pylori

Kim SS, Sung YJ, Park MK, Lim CH, Yang HJ, Kim TH, Kim CW, Kim JI, Han SW, Chung IS

  • KMID: 783099
  • Korean J Gastroenterol.
  • 2008 Nov;52(5):286-292.
BACKGROUND/AIMS: The cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), the proteins that have the role in the gastric carcinogenesis, are stimulated by H. pylori infection in the gastric mucosa....
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Effect of Heat Shock Protein 70 on Inducible Nitric Oxide Synthase during Sepsis in Rats

Lee YK, Shin HK, Kwon WY, Suh GJ, Youn YK

  • KMID: 2203456
  • J Korean Soc Traumatol.
  • 2008 Jun;21(1):59-65.
PURPOSE: The aim of this study was to evaluate the effect of overexpression of heat shock protein 70 (HSP70) on the expression of inducible nitric oxide synthase and on the...
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Protein Kinase C-alpha Regulates Toll-like Receptor 4-Mediated Inducible Nitric Oxide Synthase Expression

Lee JG, Chin BR, Baek SH

  • KMID: 1485993
  • J Korean Assoc Oral Maxillofac Surg.
  • 2008 Feb;34(1):28-35.
PURPOSE: The nitric oxide (NO) release by inducible nitric oxide synthase (iNOS) is the key events in macrophage response to lipopolysaccharide (LPS) which is suggested to be a crucial mediator...
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Inducible Nitric Oxide Synthase (iNOS) Expression in the Hypoxic Injury to Pancreatic Beta (MIN6) Cells

Ko SH, Kim SB, Ryu KR, Kim JW, Ahn YB, Moon SD, Kim SR, Lee JM, Kwon HS, Yoon KH, Song KH

BACKGROUND: Islet transplantation is an alternative potential strategy to cure type 1 diabetes mellitus. However, two or more donors are usually needed for one recipient because a substantial part of...
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