- Evaluation of MET alteration in EGFR-mutant non-small cell lung cancer patients treated with EGFR tyrosine kinase inhibitor from paired biopsy: A retrospective cohort study
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Ku BM, Park S, Park S, Jung HA, Sun JM, Lee SH, Ahn JS, Choi YL, Ahn MJ
- KMID: 2538088
- Precis Future Med.
- 2022 Dec;6(4):233-242.
- doi: 10.23838/pfm.2022.00058
Purpose: Mesenchymal-epithelial transition tyrosine kinase receptor (MET) amplification is one of the common acquired resistance mechanisms to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). To evaluate the usefulness... -
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- The Implication of Cytogenetic Alterations in Pancreatic Ductal Adenocarcinoma and Intraductal Papillary Mucinous Neoplasm Identified by Fluorescence In Situ Hybridization and Their Potential Diagnostic Utility
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Lim CS, Im K, Lee DS, Kwon W, Kim JR, Han Y, Kim SW, Jang JY
- KMID: 2504208
- Gut Liver.
- 2020 Jul;14(4):509-520.
- doi: 10.5009/gnl19087
Background/Aims: We investigated chromosomal aberrations in patients with pancreatic ductal adenocarcinoma (PDAC) and intraductal papillary mucinous neoplasm (IPMN) by fluorescence in situ hybridization (FISH) to identify cytogenetic changes and molecular... -
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- Molecular Testing of Lymphoproliferative Disorders: Current Status and Perspectives
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Jeon YK, Yoon SO, Paik JH, Kim YA, Shin BK, Kim HJ, Cha HJ, Kim JE, Huh J, Ko YH, The Hematopathology Study Group of the Korean Society of Pathologists, The Molecular Pathology Study Group of Korean Society of Pathologists
- KMID: 2392591
- J Pathol Transl Med.
- 2017 May;51(3):224-241.
- doi: 10.4132/jptm.2017.04.09
Molecular pathologic testing plays an important role for the diagnosis, prognostication and decision of treatment strategy in lymphoproliferative disease. Here, we briefly review the molecular tests currently used for lymphoproliferative... -
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- Analysis of Histologic Features Suspecting Anaplastic Lymphoma Kinase (ALK)-Expressing Pulmonary Adenocarcinoma
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Choi IH, Kim DW, Ha SY, Choi YL, Lee HJ, Han J
- KMID: 2151140
- J Pathol Transl Med.
- 2015 Jul;49(4):310-317.
- doi: 10.4132/jptm.2015.05.13
BACKGROUND: Since 2007 when anaplastic lymphoma kinase (ALK) rearrangements were discovered in non-small cell lung cancer, the ALK gene has received attention due to ALK-targeted therapy, and a notable treatment... -
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- ALK-Positive Renal Cell Carcinoma in a Large Series of Consecutively Resected Korean Renal Cell Carcinoma Patients
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Lee C, Park JW, Suh JH, Nam KH, Moon KC
- KMID: 2141006
- Korean J Pathol.
- 2013 Oct;47(5):452-457.
BACKGROUND: Recently, there have been a few reports of renal cell carcinoma (RCC) cases with anaplastic lymphoma kinase (ALK) gene fusion. In this study, we screened consecutively resected RCCs from... -
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- Finding and Characterizing Mammary Analogue Secretory Carcinoma of the Salivary Gland
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Jung MJ, Song JS, Kim SY, Nam SY, Roh JL, Choi SH, Kim SB, Cho KJ
- KMID: 1837569
- Korean J Pathol.
- 2013 Feb;47(1):36-43.
BACKGROUND: A new tumor entity of the salivary glands, mammary analogue secretory carcinoma (MASC) with ETV6-NTRK3 translocation, has recently been proposed. MASC was originally diagnosed as adenocarcinoma, not otherwise specified... -
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- Primary Pulmonary Myxoid Liposarcoma with Translocation t(12;16)(q13;p11) in a Young Female Patient: A Brief Case Report
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Son C, Choi PJ, Roh MS
- KMID: 1439881
- Korean J Pathol.
- 2012 Aug;46(4):392-394.
- doi: 10.4132/KoreanJPathol.2012.46.4.392
Primary liposarcoma of the lung is an extremely rare disease. To date, only 14 cases have been reported in the literature. We experienced a case of myxoid liposarcoma of the... -
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- Diagnostic Value of MDM2 and DDIT3 Fluorescence In Situ Hybridization in Liposarcoma Classification: A Single-Institution Experience
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Cho J, Lee SE, Choi YL
- KMID: 2011978
- Korean J Pathol.
- 2012 Apr;46(2):115-122.
BACKGROUND: The amplification of murine double minutes (MDM2) is the primary feature of well-differentiated liposarcomas (WDLPS) and dedifferentiated liposarcomas (DDLPS), while DDIT3 rearrangement is the main one of myxoid liposarcomas... -
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- Prognostic Significance of Amplification of the c-MYC Gene in Surgically Treated Stage IB-IIB Cervical Cancer
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Kim TJ, Lee A, Lee SJ, Lee WC, Choi YJ, Lee KY, Kang CS
- KMID: 1979062
- Korean J Pathol.
- 2011 Dec;45(6):596-603.
BACKGROUND: Mutations of c-MYC have been described in cervical cancer. However, association between c-MYC gene status and its prognostic significance have not been clarified. METHODS: Tissue microarray sections from 144 patients... -
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- Evaluation of Intratumoral HER-2 Heterogeneity by Fluorescence In Situ Hybridization in Invasive Breast Cancer: A Single Institution Study
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Lee S, Jung W, Hong SW, Koo JS
- KMID: 1777837
- J Korean Med Sci.
- 2011 Aug;26(8):1001-1006.
- doi: 10.3346/jkms.2011.26.8.1001
This study aimed to determine the incidence and characteristics of HER-2 gene heterogeneity in invasive breast cancer in a single institution. Included were 971 cases of primary invasive breast cancer... -
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- HER2 Status in Gastric Adenocarcinomas Assessed by Immunohistochemistry, Automated Silver-Enhanced In Situ Hybridization and Fluorescence In Situ Hybridization
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Kim A, Bae JM, Kim SW, Gu MJ, Bae YK
- KMID: 2277558
- Korean J Pathol.
- 2010 Oct;44(5):493-501.
BACKGROUND: Recently, many studies have focused on human epidermal growth factor receptor 2 (HER2) status in gastric cancer due to HER2-targeted therapy using trastuzumab. We investigated HER2 overexpression and amplification... -
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- The Relationship between the Presence of Chromosomal Instability and Prognosis of Squamous Cell Carcinoma of the Lung: Fluorescence in situ Hybridization Analysis of Paraffin-embedded Tissue from 47 Korean Patients
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Yoo JW, Seo KW, Jang SJ, Oh YM, Shim TS, Kim WS, Lee DS, Lee SD, Choi CM
- KMID: 2150864
- J Korean Med Sci.
- 2010 Jun;25(6):863-867.
- doi: 10.3346/jkms.2010.25.6.863
To evaluate the prognostic importance of chromosomal instability (CIN) in squamous cell carcinoma (SCC) of the lung, the relationship between CIN detected by fluorescence in situ hybridization (FISH) and survival... -
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- Automated Silver-enhanced In Situ Hybridization for Evaluation of HER2 Gene Status in Breast Carcinoma: Comparison with Fluorescence In Situ Hybridization and Immunohistochemistry
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Sung WJ, Park SJ, Gu MJ, Bae YK
- KMID: 2277620
- Korean J Pathol.
- 2010 Feb;44(1):28-34.
BACKGROUND: The human epidermal growth factor receptor 2 (HER2) is amplified in 20-25% of breast cancers. HER2 overexpression or amplification is associated with a worse clinical outcome and it can... -
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- The Utility of Fluorescence In Situ Hybridization for Detection of Bladder Urothelial Carcinoma in Routine Clinical Practice
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Kwak KW, Kim SH, Lee HM
- KMID: 1783145
- J Korean Med Sci.
- 2009 Dec;24(6):1139-1144.
- doi: 10.3346/jkms.2009.24.6.1139
To evaluate the ability of fluorescence in situ hybridization (FISH) in detecting bladder urothelial carcinoma (BUC), FISH and cytology were compared for the evaluation of 308 consecutive urine samples from... -
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- Weekly Paclitaxel and Trastuzumab as a First-Line Therapy in Patients with HER2-Overexpressing Metastatic Breast Cancer: Magnitude of HER2/neu Amplification as a Predictive Factor for Efficacy
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Han HS, Kim JS, Park JH, Jeon YK, Lee KW, Oh DY, Kim JH, Park SY, Im SA, Kim TY, Park IA, Bang YJ
- KMID: 1782015
- J Korean Med Sci.
- 2009 Oct;24(5):910-917.
- doi: 10.3346/jkms.2009.24.5.910
We evaluated the efficacy and safety of weekly paclitaxel plus trastuzumab as firs-tline chemotherapy in women with HER2-overexpressing metastatic breast cancer (MBC), and we investigated the prognostic factors including magnitude... -
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- Neuronal activation increases the density of eukaryotic translation initiation factor 4E mRNA clusters in dendrites of cultured hippocampal neurons
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Moon IS, Cho SJ, Seog DH, Walikonis
- KMID: 1119326
- Exp Mol Med.
- 2009 Aug;41(8):601-610.
- doi: 10.3858/emm.2009.41.8.066
Activity-dependent dendritic translation in CNS neurons is important for the synapse-specific provision of proteins that may be necessary for strengthening of synaptic connections. A major rate-limiting factor during protein synthesis... -
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- Comparison of the Efficacy of Urine Cytology, Nuclear Matrix Protein 22 (NMP22), and Fluorescence in Situ Hybridization (FISH) for the Diagnosis of Bladder Cancer
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Kim WT, Park K, Cho NH, Ham WS, Lee JS, Ju HJ, Kwon YU, Choi YD
- KMID: 2140106
- Korean J Urol.
- 2009 Jan;50(1):6-11.
- doi: 10.4111/kju.2009.50.1.6
PURPOSE: We compared the efficacy of urine cytology, nuclear matrix protein 22 (NMP22), and fluorescence in situ hybridization (FISH) for the detection of bladder cancer. MATERIALS AND METHODS: Washing urine samples... -
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- Prognostic Significance of HER2 Gene Amplification According to Stage of Breast Cancer
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Kim YS, Won YS, Park KS, Song BJ, Kim JS, Oh SJ, Jeon HM, Jung SS, Park WC
- KMID: 1786878
- J Korean Med Sci.
- 2008 Jun;23(3):414-420.
- doi: 10.3346/jkms.2008.23.3.414
It is well known that the amplification of the HER2 gene is closely associated with poor prognosis of breast cancer. However, there is controversy about the clinical significance of HER2... -
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- A De Novo Centric Fission of Chromosome 11 in a Patient with Recurrent Miscarriages
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Shim SH, Lee CH, Lee JY, Shin ES, Kyhm JH, Park MI, Chung SR, Cho YH
- KMID: 1713255
- J Korean Med Sci.
- 2007 Feb;22(1):146-148.
- doi: 10.3346/jkms.2007.22.1.146
We report on a de novo centric fission of chromosome 11 in a healthy female referred for chromosome analysis due to recurrent miscarriages. Both fission products were mitotically stable. This... -
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- Intraneural Perineurioma in the Tongue: A Case Report
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Kang J, Khang SK, Choi J, Kim JW, Seo EJ, Lee BK, Yu E
- KMID: 1521696
- Korean J Pathol.
- 2007 Feb;41(1):51-54.
We report a case of an intraneural perineurioma that developed in an unusual location, the tongue. A 16-year-old male presented with a 1 cm sized protruding submucosal mass in his... -
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