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Diesel Exhaust Particles Impair Therapeutic Effect of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis through ROS/ERK/cFos Signaling Pathway

Park HS, Oh MK, Lee JW, Chae DH, Joo H, Kang JY, An HB, Yu A, Park JH, Yoo HM, Jung HJ, Choi U, Jung JW, Kim IS, Oh IH, Yu KR

Background and Objectives: Epidemiological investigations have shown positive correlations between increased diesel exhaust particles (DEP) in ambient air and adverse health outcomes. DEP are the major constituent of particulate atmospheric...
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Molecular Characteristics and Potent Immunomodulatory Activity of Fasciola hepatica Cystatin

Zhang K, Liu Y, Zhang G, Wang X, Li Z, Shang Y, Ning C, Ji C, Cai X, Xia X, Qiao J, Meng Q

Cystatin, a cysteine protease inhibitor found in many parasites, plays important roles in immune evasion. This study analyzed the molecular characteristics of a cystatin from Fasciola hepatica (FhCystatin) and expressed...
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The Immunomodulating Effects of Thalidomide and Dexamethasone in a Murine Cardiac Allograft Transplantation Model

Kim SJ, Kim JY, Kim EJ, Lee H, Cho Y, Kim MS, Kim YS, Kim BS, Huh KH

Purpose: The immunomodulatory effects of thalidomide (TM) and dexamethasone (DX) on immune cells and their co-stimulatory, co-inhibitory molecules in vitro and in vivo have been previously reported. The current study...
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Immunosuppression and Neuroinflammation in Stroke Pathobiology

Jiang Q, Stone CR, Elkin K, Geng X, Ding Y

  • KMID: 2515810
  • Exp Neurobiol.
  • 2021 Apr;30(2):101-112.
  • doi: 10.5607/en20033
Over the preceding decades, there have been substantial advances in our knowledge of the pathophysiology of stroke. One such advance has been an increased understanding of the multifarious crosstalk in...
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Effect of pregabalin on nociceptive thresholds and immune responses in a mouse model of incisional pain

Park JH, Cho SH, Kim R, Na SH, Kang Es, Yeom My, Jang Y

Background: It is known that some analgesics as well as pain can affect the immune system. The aim of this study was to investigate the analgesic effect and immunomodulation of...
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Systemic Immunomodulatory Effects of Combinatorial Treatment of Thalidomide and Dexamethasone on T Cells and Other Immune Cells

Kim EJ, Kim JY, Choi HY, Lee H, Lee J, Kim MS, Kim YS, Huh KH, Kim BS

Purpose In organ transplantation, the need for immune modulation rather than immune suppression has been emphasized. In this study, we investigated whether combinatorial treatments of with thalidomide (TM) and dexamethasone (DX)...
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Vaccines and Treatment of Coronavirus Disease 2019

Choe PG

In December 2019, a new strain of betacoronavirus, severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19), emerged in Wuhan, China. Subsequently, the virus quickly spread worldwide...
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Effectiveness of Intravenous Immunoglobulin Therapy for Pediatric Viral Encephalitis

Byun JE, Lee KY

Purpose: Intravenous immunoglobulin (IVIg) is considered as a first-line therapy for autoimmune encephalitis. However, its effectiveness in viral encephalitis has yet to be evaluated. Therefore, we investigated the effectiveness of...
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Arthrospira (Spirulina) platensis Attenuates Dextran Sulfate Sodium-induced Colitis in Mice by Suppressing Key Pro-inflammatory Cytokines

Garcia FAdO, Sales-Campos H, Yuen VG, Machado JR, Viana GSdB, Oliveira CJF, McNeill JH

Background/Aims: Therapies aimed at modulating cytokines have been used to treat inflammatory illnesses, such as inflammatory bowel disease. On the other hand, patients may become intolerant, refractory, or present with...
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SOCS1 Regulates the Immunomodulatory Roles of MSCs on B Cells

Zhang L, Qu YN, Zhang HY, Wu ZY, Li ZL, Guo WB, Wang QB, Fang NZ, Jiang XX

Background and Objectives: The effective use of MSCs for the treatment of some B cell-mediated immune diseases is quite limited. The main reason is that the immunomodulatory effects of mesenchymal...
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Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Ace Card to Address Autoimmune Diseases

Baharlooi , Azimi M, Salehi Z, Izad M

With the development of novel treatments for autoimmune disorders, it has become a popular research focus which mesenchymal stem cells (MSCs) have the capacity to counteract with autoimmune diseases progression....
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Protective Effect of Sphaerococcus coronopifolius Crude Extract in Combination with Bacillus Calmette-Guerin on Ligature-Induced Depression in Female Wistar Rats

Fellah F, Djenidi R, Chebout I

Objective Immunomodulation is a therapeutic technique that modulates the balance of cytokines in the body. In this regard, our experiment was conducted to investigate the potential effect of S. coronopifolius...
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Neuroinflammation after Intracerebral Hemorrhage and Potential Therapeutic Targets

Tschoe C, Bushnell C, Duncan PW, Alexander-Miller MA, Wolfe SQ

Spontaneous intracerebral hemorrhage (ICH) is a catastrophic illness causing significant morbidity and mortality. Despite advances in surgical technique addressing primary brain injury caused by ICH, little progress has been made...
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Efficacy of Allergen Immunotherapy for Allergic Asthma in Real World Practice

Rhyou HI, Nam YH

PURPOSE: Allergen immunotherapy (AIT) induces immunological tolerance, and there is increasing evidence of the clinical efficacy of AIT in the treatment of allergic asthma. However, the optimal parameters for asthma...
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Immunomodulation for maxillofacial reconstructive surgery

Kim SG

Immunomodulation is a technique for the modulation of immune responses against graft material to improve surgical success rates. The main target cell for the immunomodulation is a macrophage because it...
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Mesenchymal Stem Cells from the Wharton's Jelly of the Human Umbilical Cord: Biological Properties and Therapeutic Potential

Marino L, Castaldi M, Rosamilio , Ragni E, Vitolo R, Fulgione C, Castaldi S, Serio B, Bianco R, Guida M, Selleri C

Wharton's jelly mesenchymal stem cells (WJ-MSCs) are a class of stem cells with high differentiative potential, an immuno-privileged status and easy access for collection, which raise no legal or ethical...
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Cortical Bone Derived Stem Cells for Cardiac Wound Healing

Mohsin S, Houser SR

Ischemic heart disease can lead to myocardial infarction (MI), a major cause of morbidity and mortality worldwide. Adoptive transfer of multiple stem cell types into failing human hearts has demonstrated...
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Osteonecrosis of the jaw in the era of targeted therapy and immunotherapy in oncology

Nifosì AF, Zuccarello M, Nifosì L, Hervas Saus V, Nifosì G

Osteonecrosis of the jaw (ONJ) is a well-known pathological condition in oncology derived from the use of bisphosphonates (BPs) and denosumab. Many molecular and immunological targets have been introduced for...
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Apoptotic Cell-Mimetic Polymers for Anti-Inflammatory Therapy

Ebara M

The field of biomaterials has seen a strong rejuvenation due to the new potential to modulate immune system in our body. This special class of materials is called “immunomodulatory biomaterials”....
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Roles of Mesenchymal Stem Cells in Tissue Regeneration and Immunomodulation

Ayala-Cuellar AP, Kang JH, Jeung EB, Choi KC

Mesenchymal stem cells are classified as multipotent stem cells, due to their capability to transdifferentiate into various lineages that develop from mesoderm. Their popular appeal as cell-based therapy was initially...
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