- Cytokines and Immune Disorders: Illuminating Cytokines as Hubs Within the Immune Network
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Lee SW, Lee CK
- KMID: 2557914
- Immune Netw.
- 2024 Feb;24(1):e13.
- doi: 10.4110/in.2024.24.e13
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- IL-17 and IL-21: Their Immunobiology and Therapeutic Potentials
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Koh CH, Kim BS, Kang CY, Chung Y, Seo H
- KMID: 2557916
- Immune Netw.
- 2024 Feb;24(1):e2.
- doi: 10.4110/in.2024.24.e2
Studies over the last 2 decades have identified IL-17 and IL-21 as key cytokines in the modulation of a wide range of immune responses. IL-17 serves as a critical defender... -
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- Innate Type-2 Cytokines: From Immune Regulation to Therapeutic Targets
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Kim HY, Jeong D, Kim JH, Chung DH
- KMID: 2557919
- Immune Netw.
- 2024 Feb;24(1):e6.
- doi: 10.4110/in.2024.24.e6
The intricate role of innate type-2 cytokines in immune responses is increasingly acknowledged for its dual nature, encompassing both protective and pathogenic dimensions. Ranging from defense against parasitic infections to contributing... -
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- IL-15 in T-Cell Responses and Immunopathogenesis
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Lee H, Park SH, Shin EC
- KMID: 2557913
- Immune Netw.
- 2024 Feb;24(1):e11.
- doi: 10.4110/in.2024.24.e11
IL-15 belongs to the common gamma chain cytokine family and has pleiotropic immunological functions. IL-15 is a homeostatic cytokine essential for the development and maintenance of NK cells and memory... -
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- Optimising IL-2 for Cancer Immunotherapy
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Sprent J, Boyman O
- KMID: 2557918
- Immune Netw.
- 2024 Feb;24(1):e5.
- doi: 10.4110/in.2024.24.e5
The key role of T cells in cancer immunotherapy is well established and is highlighted by the remarkable capacity of Ab-mediated checkpoint blockade to overcome T-cell exhaustion and amplify anti-tumor... -
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- Harnessing the Power of IL-7 to Boost T Cell Immunity in Experimental and Clinical Immunotherapies
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Park JH, Lee SW, Choi D, Lee C, Sung YC
- KMID: 2557921
- Immune Netw.
- 2024 Feb;24(1):e9.
- doi: 10.4110/in.2024.24.e9
The cytokine IL-7 plays critical and nonredundant roles in T cell immunity so that the abundance and availability of IL-7 act as key regulatory mechanisms in T cell immunity. Importantly, IL-7... -
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- TNF in Human Tuberculosis: A Double-Edged Sword
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Yuk JM, Kim JK, Kim IS, Jo EK
- KMID: 2557917
- Immune Netw.
- 2024 Feb;24(1):e4.
- doi: 10.4110/in.2024.24.e4
TNF, a pleiotropic proinflammatory cytokine, is important for protective immunity and immunopathology during Mycobacterium tuberculosis (Mtb) infection, which causes tuberculosis (TB) in humans. TNF is produced primarily by phagocytes in... -
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- Cytokines, Vascular Endothelial Growth Factors, and PlGF in Autoimmunity: Insights From Rheumatoid Arthritis to Multiple Sclerosis
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Lee Ye, Lee SH, Kim WU
- KMID: 2557912
- Immune Netw.
- 2024 Feb;24(1):e10.
- doi: 10.4110/in.2024.24.e10
In this review, we will explore the intricate roles of cytokines and vascular endothelial growth factors in autoimmune diseases (ADs), with a particular focus on rheumatoid arthritis (RA) and multiple... -
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- Interleukin-18 Binding Protein (IL-18BP): A Long Journey From Discovery to Clinical Application
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Kim S, Yu H, Azam T, Dinarello CA
- KMID: 2557915
- Immune Netw.
- 2024 Feb;24(1):e1.
- doi: 10.4110/in.2024.24.e1
IL-18 binding protein (IL-18BP) was originally discovered in 1999 while attempting to identify an IL-18 receptor ligand binding chain (also known as IL-18Rα) by subjecting concentrated human urine to an... -
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- Cytokines in Follicular Helper T Cell Biology in Physiologic and Pathologic Conditions
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Choi J, Crotty S, Choi YS
- KMID: 2557920
- Immune Netw.
- 2024 Feb;24(1):e8.
- doi: 10.4110/in.2024.24.e8
Follicular helper T cells (Tfh) play a crucial role in generating high-affinity antibodies (Abs) and establishing immunological memory. Cytokines, among other functional molecules produced by Tfh, are central to germinal... -
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