- Engineering Cell Therapies for Autoimmune Diseases: From Preclinical to Clinical Proof of Concept
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Oh S, Payne AS
- KMID: 2536264
- Immune Netw.
- 2022 Oct;22(5):e37.
- doi: 10.4110/in.2022.22.e37
Autoimmune diseases are caused by a dysfunction of the acquired immune system. In a subset of autoimmune diseases, B cells escaping immune tolerance present autoantigen and produce cytokines and/or autoantibodies,... -
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- Exosomal Communication Between the Tumor Microenvironment and Innate Immunity and Its Therapeutic Application
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Kong H, Kim SB
- KMID: 2536265
- Immune Netw.
- 2022 Oct;22(5):e38.
- doi: 10.4110/in.2022.22.e38
Exosomes, which are well-known nanoscale extracellular vesicles, are multifunctional biomaterials derived from endosomes and perform various functions. The exosome is a critical material in cell-cell communication. In addition, it regulates... -
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- RNA Metabolism in T Lymphocytes
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Choi JO, Ham JH, Hwang SS
- KMID: 2536266
- Immune Netw.
- 2022 Oct;22(5):e39.
- doi: 10.4110/in.2022.22.e39
RNA metabolism plays a central role in regulating of T cell-mediated immunity. RNA processing, modifications, and regulations of RNA decay influence the tight and rapid regulation of gene expression during... -
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- Application of Antimicrobial Peptide LL-37 as an Adjuvant for Middle East Respiratory Syndrome-Coronavirus Antigen Induces an Efficient Protective Immune Response Against Viral Infection After Intranasal Immunization
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Kim J, Yang YL, Jeong Y, Jang YS
- KMID: 2536268
- Immune Netw.
- 2022 Oct;22(5):e41.
- doi: 10.4110/in.2022.22.e41
The human antimicrobial peptide LL-37 has chemotactic and modulatory activities in various immune cells, including dendritic cells. Because of its characteristics, LL-37 can be considered an adjuvant for vaccine development.... -
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- 1,3-Dibenzyl-5-Fluorouracil Prevents Ovariectomy-Induced Bone Loss by Suppressing Osteoclast Differentiation
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Jeon H, Yu J, Hwang JM, Park HW, Yu J, Lee ZW, Kim T, Rho J
- KMID: 2536270
- Immune Netw.
- 2022 Oct;22(5):e43.
- doi: 10.4110/in.2022.22.e43
Osteoclasts (OCs) are clinically important cells that resorb bone matrix. Accelerated bone destruction by OCs is closely linked to the development of metabolic bone diseases. In this study, we screened... -
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- Mesenchymal Stem Cells Attenuate Asthmatic Inflammation and Airway Remodeling by Modulating Macrophages/Monocytes in the IL-13-Overexpressing Mouse Model
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Mo Y, Kim Y, Bang JY, Jung J, Lee CG, Elias JA, Kang HR
- KMID: 2536267
- Immune Netw.
- 2022 Oct;22(5):e40.
- doi: 10.4110/in.2022.22.e40
Mesenchymal stem cells (MSCs) are attractive alternatives to conventional anti-asthmatic drugs for severe asthma. Mechanisms underlying the anti-asthmatic effects of MSCs have not yet been elucidated. This study evaluated the... -
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- Efficient Anti-Tumor Immunotherapy Using Tumor Epitope-Coated Biodegradable Nanoparticles Combined With Polyinosinic-Polycytidylic Acid and an Anti-PD1 Monoclonal Antibody
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Kim SH, Park JH, Lee SJ, Lee HS, Jung JK, Lee YR, Cho HI, Kim JK, Kim K, Park CS, Lee CK
- KMID: 2536269
- Immune Netw.
- 2022 Oct;22(5):e42.
- doi: 10.4110/in.2022.22.e42
Vaccination with tumor peptide epitopes associated with MHC class I molecules is an attractive approach directed at inducing tumor-specific CTLs. However, challenges remain in improving the therapeutic efficacy of peptide... -
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