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Mechanism of Differential Ag-specific Immune Induction by Different Tumor Cell Lysate Pulsed DC

Lee KE, Shon HJ, Kim MJ, Baek S, Lee H

BACKGROUND: Tumor cell lysate has been considered as a preferential antigen source for the therapeutic dendritic cell pulsing. Our experiences with in vivo study with animal tumor model indicate the...
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Ectopic Expression of Caveolin-1 Induces COX-2 Expression in Rabbit Articular Chondrocytes via MAP Kinase Pathway

Kim SJ

BACKGROUND: Caveolin-1 is a principal component of caveolae membranes in vivo. Although expression of caveolae structure and expression of caveolin family, caveolin-1, -2 and -3, was known in chondrocytes, the...
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Apoptosis-Induced Gene Profiles of a Myeloma Cell P3-X63-Ag8.653

Bahng HS, Chung YH

BACKGROUND: Apoptosis is a physiologic phenomenon involved in development, elimination of damaged cells, and maintenance of cell homeostasis. Deregulation of apoptosis may cause diseases, such as cancers, immune diseases, and...
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Effect of Dexamethasone on the Surface Expression of Marker Molecules and Differentiation of Murine B Cells

Yeo SG, Park DC, Cha CI

BACKGROUND: There are at least two different subsets of B cells, B-1 and B-2. The characteristic features and function of B-2 cells in addition to the effect of steroids on...
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p38 Kinase Regulates Nitric Oxide-induced Dedifferentiation and Cyclooxygenase-2 Expression of Articular Chondrocytes

Yu SM, Cheong SW, Cho SR, Kim SJ

BACKGROUND: Caveolin, a family of integral membrane proteins are a principal component of caveolae membranes. In this study, we investigated the effect of p38 kinase on differentiation and on inflammatory...
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Anti-cancer Effect of Hematopoietic Stem Cell-derived Allogeneic-DC Vaccine in Melanoma Metastasis Model

Kim MJ, Shon HJ, Baek S, Lee KE, Lee YJ, Lee H

BACKGROUND: Dendritic cell (DC)-based cancer immunotherapy is studied for several years. However, it is mainly derived from autologous PBMC or leukapheresis from patient, which has limitations about yield and ability...
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