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ACY-241, a histone deacetylase 6 inhibitor, suppresses the epithelial–mesenchymal transition in lung cancer cells by downregulating hypoxia-inducible factor-1 alpha

Park SJ, Lee N, Jeong CH

Hypoxia-inducible factor-1 alpha (HIF-1α) is a transcription factor activated under hypoxic conditions, and it plays a crucial role in cellular stress regulation. While HIF-1α activity is essential in normal tissues, its...
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Deterioration and Recurrence in Flight Passengers with Ischemic Stroke: An Evidence Based Case Report

Riski AD, Saputera MD, Hamdiyati R, Afian F

Ischemic stroke is a cerebrovascular disease characterized by a sudden neurological deficit due to thrombotic or embolic event. The physiological changes during in-flight related to high altitude, hypobaric hypoxic, is...
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Decreased Angiopoietin Expression in Underactive Bladder Induced by Long-term Bladder Outlet Obstruction

Kim JH, Yang HJ, Lee HJ, Song YS

Purpose: Ischemia of the bladder can occur if neovascular formation cannot keep pace with hypoxia induced by chronic bladder outlet obstruction (BOO). The aim of this study was to examine...
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Unraveling the hypoxia modulating potential of VEGF family genes in pan-cancer

Bae SH, Hwang T, Han MR

Tumor hypoxia, oxygen deprivation state, occurs in most cancers and promotes angiogenesis, enhancing the potential for metastasis. The vascular endothelial growth factor (VEGF) family genes play crucial roles in tumorigenesis...
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Effects of aging on accompanying intermittent hypoxia in a bleomycin-induced pulmonary fibrosis mouse model

Lee H, Kim IK, Im J, Jin BS, Kim HH, Kim SW, Yeo CD, Lee SH

Background/Aims: Obstructive sleep apnea (OSA) is prevalent in older patients with idiopathic pulmonary fibrosis (IPF); however, it is underrecognized. OSA is characterized by intermittent hypoxia (IH) and sleep fragmentation. In...
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A pediatric case of portosystemic shunt presenting hypoxemia with brain abscess in an emergency department

Hwang ST, Park JS

Portosystemic shunt is a rare congenital vascular anomaly. The shunt is hard to clinically suspect because its symptoms develop insidiously and affect various systems at different time points. We report...
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Treatment Outcomes of Mandibular Advancement Devices in Mild, Moderate, and Severe Obstructive Sleep Apnea: A Preliminary Study

Kim HK, Kim ME

Purpose: Mandibular advancement devices (MAD) are known to be insufficiently effective in all patients with obstructive sleep apnea (OSA). This study aimed to compare the treatment outcomes of MAD therapy...
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The impact of hypoxia-inducible factors in the pathogenesis of kidney diseases: a link through cell metabolism

Foresto-Neto O, da Silva ARPA, Cipelli M, Santana-Novelli FPR, Camara NOS

Kidneys are sensitive to disturbances in oxygen homeostasis. Hypoxia and activation of the hypoxia-inducible factor (HIF) pathway alter the expression of genes involved in the metabolism of renal and immune...
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A case of acute kidney injury caused by dapsone-induced methemoglobinemia in a patient with chronic kidney disease

Kim M, Kim SI, Jo JR, Oh JH, Cho AY, Lee KY, Sun IO

  • KMID: 2545611
  • J Korean Soc Emerg Med.
  • 2023 Aug;34(4):379-382.
Methemoglobinemia (MetHb), which is characterized by an increased methemoglobin level, is a rare but potentially fatal disorder caused by congenital enzyme deficiencies or exposure to oxidizing agents, including dapsone. Elevation...
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D-Galactose and Hypoxia Induce the Early Onset of Age-Related Hearing Loss Deterioration in a Mouse Model

Temuulen T, Choi JS, Ha SM, Ahn Y, Seo YJ

BACKGROUND: We previously showed that aging accelerates after 3 months of exposure to hypoxia and environmental change but not genetic modifications. Here, we aimed to simply induce early-onset age-related hearing...
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Hypoxia Differentially Affects Chondrogenic Differentiation of Progenitor Cells from Different Origins

Hammad M, Veyssiere A, Leclercq S, Patron V, Baugé C, Boumédiene K

Background and Objectives: Ear cartilage malformations are commonly encountered problems in reconstructive surgery, since cartilage has low self-regenerating capacity. Malformations that impose psychological and social burden on one’s life are...
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Notch Is Not Involved in Physioxia-Mediated Stem Cell Maintenance in Midbrain Neural Stem Cells

Herrmann A, Meyer AK, Braunschweig L, Wagenfuehr L, Markert F, Kolitsch D, Vukicevic V, Hartmann C, Siebert M, Ehrhart-Bornstein M, Hermann A, Storch A

Background and Objectives: The physiological oxygen tension in fetal brains (∼3%, physioxia) is beneficial for the maintenance of neural stem cells (NSCs). Sensitivity to oxygen varies between NSCs from different...
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Conversion to Veno-arteriovenous Extracorporeal Membrane Oxygenation for Differential Hypoxia

Cha HJ, Kim JW, Kang DH, Moon SH, Kim SH, Jung JJ, Yang JH, Byun JH

Background: Patients who require initial venoarterial extracorporeal membrane oxygenation (VA ECMO) support may need to undergo veno-arteriovenous ECMO (VAV ECMO) conversion. However, there are no definitive criteria for conversion to...
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A Case of Diffuse Dermal Angiomatosis on the Chest Wall

Cho M, Lee JD, Cho SH, Woo YR, Kim HS

  • KMID: 2543899
  • Korean J Dermatol.
  • 2023 Jun;61(5):328-330.
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The usual sedative dose in very elderly patients with a good neurological outcome after cardiac arrest can cause a suppressed background and burst suppression: two case reports

Lee JH

Highly malignant electroencephalogram (EEG) patterns (including suppressed background and burst suppression) refer to a poor neurological outcome in cardiac arrest patients, but some of those patients may show a good...
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Regenerative Effect of Adipose Derived Mesenchymal Stem Cells on Ganglion Cells in the Hypoxic Organotypic Retina Culture

Dov MB, Krief B, Benhamou M, Klein A, Schwartz S, Loewenstein A, Barak A, Barzelay A

Background and Objectives: To examine whether ischemic retinal ganglion cells (RGCs) will be salvaged from cell death by human adipose-derived mesenchymal stem cells (ADSCs) in an organotypic retina model. Methods and...
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Assessing Cerebral Oxygen Metabolism Changes in Patients With Preeclampsia Using Voxel-Based Morphometry of Oxygen Extraction Fraction Maps in Magnetic Resonance Imaging

Zhang Q, Sui C, Cho J, Yang L, Chen T, Guo B, Gillen KM, Li J, Guo L, Wang Y

Objective: The objective of this study was to analyze the different brain oxygen metabolism statuses in preeclampsia using magnetic resonance imaging and investigate the factors that affect cerebral oxygen metabolism...
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Myocardin Reverses Hypoxia-Inducible Factor-1α Mediated Phenotypic Modulation of Corpus Cavernosum Smooth Muscle Cells in Hypoxia Induced by Cobalt Chloride

Zhou X, Luo C, Fan J, Gao G, Wang T, Zhang H, Wei A

Purpose We aimed to investigate the mechanism of phenotypic transformation of corporal cavernosum smooth muscle cells (CCSMCs) under hypoxic conditions in vitro. Materials and Methods In this study, a hypoxia model was established...
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Anti-fibrotic effect of tocotrienols for bladder dysfunction due to partial bladder outlet obstruction

Iguchi N, Dönmez Mİ, Malykhina AP, Wilcox DT

Purpose: To investigate potential beneficial effects of tocotrienols which have been suggested to inhibit hypoxia-inducible factor (HIF) pathway, on partial bladder outlet obstruction (PBOO)-induced bladder pathology. Materials and Methods: PBOO was...
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The role of roxadustat in chronic kidney disease patients complicated with anemia

Liu J, Yang F, Waheed Y, Li S, Liu K, Zhou X

The incidence of chronic kidney disease (CKD) is increasing worldwide and the current prevalence rate is 13.4%. There are > 120 million CKD patients in China and this number is...
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