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Acanthosis nigricans as a clinical marker of insulin resistance among overweight adolescents

Videira-Silva A, Albuquerque C, Fonseca H

PURPOSE: Acanthosis nigricans (AN) is a hyperpigmented dermatosis associated with obesity and insulin resistance (IR). There is no consensus whether AN extension scoring offers added value to the clinical estimation...
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The combination of canagliflozin and omega-3 fatty acid ameliorates insulin resistance and cardiac biomarkers via modulation of inflammatory cytokines in type 2 diabetic rats

Safhi MM, Anwer T, Khan G, Siddiqui R, Moni Sivakumar S, Alam MF

The present study was carried out with the hypothesis that combination of canagliflozin and omega-3 fatty acid may have potential effect on insulin level, insulin resistance, cardiac biomarkers, inflammatory cytokines...
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Hyperinsulinemic Hypoglycemia Caused by Acute Reduction of Renal Function on an Eldery Patient Without Diabetes

Yeo JH, Kim JE, Park ES, Park JH, Kim DS, Choi WH, Ahn YH, Kim HJ, Hong SM, Lee CB

In patient with renal failure, hypoglycemia may develop because of decreased caloric intake, diminished renal insulin degradation and clearance, reduced renal gluconeogenesis and hepatic glucose production, impaired release of counter-regulatory...
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Circulating Concentrations of C-Peptide and Colorectal Adenoma

Choi YJ, Kim YH, Cho CH, Kim SH, Lee JE

Hyperinsulinemia may increase the risk of colorectal neoplasia because of its mitogenic and antiapoptotic properties, which have a growth-promoting effect. We examined the association between circulating concentrations of C-peptide, a...
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Metabolic Syndrome and Dementia

Lee AY

  • KMID: 2343398
  • J Korean Neurol Assoc.
  • 2011 Aug;29(3):159-164.
The essential components of metabolic syndrome are insulin resistance, obesity, hypertension, and dyslipidemia. It is difficult to estimate its prevalence because several definitions of metabolic syndrome are in use. Although...
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A case of adult nesidioblastosis mimicking an insulinoma and autoimmune hypoglycemia

Lee Y, Kim M, Kim TH, Lim JA, Kim SJ, Kim H, Choi SH

  • KMID: 2259190
  • Korean J Med.
  • 2010 Mar;78(3):375-380.
Hyperinsulinemic hypoglycemia in the absence of exogenous insulin use is caused by disorders such as insulinoma, diffuse beta-cell hyperplasia/nesidioblastosis, and autoimmune hypoglycemia. Nesidioblastosis is a rare cause of hypoglycemia in...
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Insulin Resistance and Insulin Resistance Syndrome

Park KS

  • KMID: 2168163
  • Hanyang Med Rev.
  • 2009 May;29(2):130-133.
Insulin resistance is the main pathophysiologic abnormality of type 2 diabetes mellitus. Insulin resistance and resultant compensatory hyperinsulinemia are closely associated with other important cardiovascular risk factors such as hypertension,...
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A case of type 2 diabetes manifested by hypokalemic periodic paralysis

Yeom DH, Kim HY, Park BH, Cho CG

  • KMID: 2305835
  • Korean J Med.
  • 2009 Apr;76(4):499-501.
Hypokalemic periodic paralysis may be precipitated by stress, rest after exercise, or events that lower serum potassium levels, such as carbohydrate ingestion or the use of insulin or diuretics. In...
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A Case of Surgical Treatment of Nesidioblastosis with Hyperinsulinemic Hypoglycemia in an Adult

Kang BS, Kang SI, Koo HY, Lee SB, Kang HY, Park SW, Chung CW

  • KMID: 1481745
  • Korean J Hepatobiliary Pancreat Surg.
  • 2008 Dec;12(4):302-306.
Nesidioblastosis is a rare disorder, and it usually considered as a cause of neonatal hyperinsulinemic hypoglycemia. A 35 year-old-woman with hyperinsulinemic hypoglycemia was admitted in an unconscious condition. Abdominal CT,...
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A Case of Persistent Hyperinsulinemic Hypoglycemia Treated with Diazoxide

Kim MS, Park EH, Kim SY, Lee DY

  • KMID: 1520749
  • J Korean Soc Pediatr Endocrinol.
  • 2007 Dec;12(2):164-167.
Congenital hyperinsulinism (CHI), the most important cause of hyperglycemia in early infancy, is a heterogenous disease characterized by dysregulation of insulin secretion. Mutations in five proteins have been associated with...
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Factors Related to Complications of Childhood Obesity

Ahn JG, Kim JM, Shin JH

  • KMID: 1510415
  • J Korean Soc Pediatr Endocrinol.
  • 2006 Jun;11(1):76-84.
PURPOSE: Childhood obesity is associated with complications such as hyperinsulinemia/insulin resistance, dyslipidemia and fatty liver. The aims of this study were to evaluate the difference of measurements between obese and...
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Recent Advances in the Management of Polycystic Ovary Syndrome

Kim CH

  • KMID: 2272646
  • Korean J Obstet Gynecol.
  • 2005 Aug;48(8):1851-1869.
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting women, and the most frequent cause of anovulatory infertility with high circulating levels of luteinizing hormone (LH),...
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A case of hypokalemic perodic paralysis induced by hyperinsulinemia

Chang JH, Kim CS, Park JK, Park J, Cho MH, Ahn CW, Kim KR

  • KMID: 1833291
  • Korean J Med.
  • 2005 Jun;68(6):692-696.
Hypokalemia periodic paralysis, a clinical syndrome characterised by systemic weakness and low serum potassium, is a rare but treatable cause of acute weakness. Attacks of flaccid paralysis can be associated...
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The Effects of High Glucose, Insulin and TGF-beta 1 on Proliferation and Differentiation of the Pancreatic Stellate Cells

Hong OK, Kwon HS, Yeom KH, Lee M, Yang JH, Ko SH, Yoo SJ, Son HS, Yoon KH, Cha BY, Lee KW, Son HY, Kang SK

  • KMID: 1768000
  • J Korean Diabetes Assoc.
  • 2003 Jun;27(3):228-240.
BACKGROUND: Although chronic pancreatitis gives rise to fibrosis of pancreatic exocrine tissue, and type 2 diabetes is accompanied by pancreatic fibrosis, the mechanisms of fibrogenesis in the pancreas have been...
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Effects of Insulin Level on Dyslipidemia in Children with Simple Obesity

Lim JS, Shin CH, Yang SW

  • KMID: 1946175
  • J Korean Pediatr Soc.
  • 2002 Jun;45(6):764-772.
PURPOSE: Obesity is closely related to insulin resistance, compensatory hyperinsulinemia and dyslipidemia in adults. We identified the effect of obesity measured by BMI and insulin resistance on dyslipidemia in children...
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Relationship between Serum Leptin Levels and Other Predictors in Obese Children

Park SJ, Park KW, Hong YM

  • KMID: 2207348
  • J Korean Pediatr Soc.
  • 2001 Oct;44(10):1103-1111.
PURPOSE: The product of the ob gene, leptin is an adipocyte specific hormone that might be involved in the regulation of food intake by the central neuroendocrine system. Recent studies...
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Two Cases of Autoimmune Insulin Syndrome with Hypoglycemia

Park SH, Lee SW, Jeong GH, Choi CH, Lee SH, Han JH, Kim JG, Ha SW, Kim BW

  • KMID: 1837614
  • J Korean Soc Endocrinol.
  • 2001 Oct;16(4-5):508-513.
Autoimmune insulin syndrome is characterized by insulin autoantibody, hyperinsulinemia, and fasting hypoglycemia without previous insulin immunization. This syndrome shows discordant levels between immunoreactive insulin and C-peptide. Negative results of an...
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Risk Factors for Fatty Liver in Obese Children

Park KW, Lee JE, Ryu KH, Kim KH, Hong YM, Kim GH, Lee K, Yoo JH

  • KMID: 1606280
  • J Korean Pediatr Soc.
  • 2001 Jun;44(6):669-676.
PURPOSE: The incidence of obese patients has increased recently in Korea. Obesity is associated with hypertension, hyperlipidemia, insulin resistance, and fatty liver. Since recent investigators have revealed that not only...
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Clustering of Risk Variables in Insulin Resistance Syndrome in Jungup District, Korea

Kim SW, Huh MH, Kim YI, Kim JY, Kim ES, Lee MS, Park JY, Hong SK, Lee KU

  • KMID: 2063357
  • J Korean Diabetes Assoc.
  • 1999 Dec;23(6):843-856.
BACKGROUND: Insulin resistance syndrome (IRS), a clustering of hypertension, impaired glucose tolerance, low HDL cholesterol and high triglyceride, is prevalent in Korea. We studied the correlational structure of IRS using...
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Characteristics of the Anthropometry and Plasma Lipid Profiles of Patients with Simple and Combined Hypercholesterolemia

Huh YR, Hwang KH, Lim HS

  • KMID: 2300777
  • Korean J Community Nutr.
  • 1999 Jun;4(2):186-193.
Recent epidemiologic and clinical students have shown that plasma cholesterol and triglyceride levels are independent risk factors for coronary heart disease. However, there is not much data on the characteristics...
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