- Astrocytes and Microglia as Non-cell Autonomous Players in the Pathogenesis of ALS
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Lee J, Hyeon SJ, Im H, Ryu H, Kim Y, Ryu H
- KMID: 2354876
- Exp Neurobiol.
- 2016 Oct;25(5):233-240.
- doi: 10.5607/en.2016.25.5.233
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder that leads to a progressive muscle wasting and paralysis. The pathological phenotypes are featured by severe motor neuron death and glial... -
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- Genetic Ablation of EWS RNA Binding Protein 1 (EWSR1) Leads to Neuroanatomical Changes and Motor Dysfunction in Mice
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Yoon Y, Park H, Kim S, Nguyen PT, Hyeon SJ, Chung S, Im H, Lee J, Lee SB, Ryu H
- KMID: 2410471
- Exp Neurobiol.
- 2018 Apr;27(2):103-111.
- doi: 10.5607/en.2018.27.2.103
A recent study reveals that missense mutations of EWSR1 are associated with neurodegenerative disorders such as amyotrophic lateral sclerosis, but the function of wild-type (WT) EWSR1 in the central nervous... -
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- Quantitative Proteomic Analysis Reveals Impaired Axonal Guidance Signaling in Human Postmortem Brain Tissues of Chronic Traumatic Encephalopathy
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Bi B, Choi HP, Hyeon SJ, Sun S, Su N, Liu Y, Lee J, Kowall NW, McKee AC, Yang JH, Ryu H
- KMID: 2451072
- Exp Neurobiol.
- 2019 Jun;28(3):362-375.
- doi: 10.5607/en.2019.28.3.362
Chronic traumatic encephalopathy (CTE) is a distinct neurodegenerative disease that associated with repetitive head trauma. CTE is neuropathologically defined by the perivascular accumulation of abnormally phosphorylated tau protein in the... -
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- Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy
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Seo JS, Lee S, Shin JY, Hwang YJ, Cho H, Yoo SK, Kim Y, Lim S, Kim YK, Hwang EM, Kim SH, Kim CH, Hyeon SJ, Yun JY, Kim J, Kim Y, Alvarez VE, Stein TD, Lee J, Kim DJ, Kim JI, Kowall NW, Ryu H, McKee AC
- KMID: 2382695
- Exp Mol Med.
- 2017 May;49(5):e333.
- doi: 10.1038/emm.2017.56
Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disorder that is associated with repetitive head injury and has distinctive neuropathological features that differentiate this disease from other neurodegenerative diseases. Intraneuronal... -
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