- Ultrafast liquid chromatographytandem mass spectrometry determination of donepezil in human plasma: application to a bioequivalence study
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Huang YW, Ding L, Chen YM, Lin Wc, Lin F, Hsieh Y
- KMID: 2538271
- Transl Clin Pharmacol.
- 2022 Mar;30(1):37-48.
- doi: 10.12793/tcp.2022.30.e1
A liquid chromatography equipped with tandem mass spectrometric method using multistage flow rates was developed for the determination of donepezil in human plasma to support a randomized, crossover bioequivalence (BE)... -
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- Dysregulated Free Fatty Acid Receptor 2 Exacerbates Colonic Adenoma Formation in ApcMin/+ Mice: Relation to Metabolism and Gut Microbiota Composition
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Huang YW, Lin CW, Pan P, Echeveste CE, Dong A, Oshima K, Yearsley M, Yu J, Wang LS
- KMID: 2514693
- J Cancer Prev.
- 2021 Mar;26(1):32-40.
- doi: 10.15430/JCP.2021.26.1.32
Free fatty acid receptor 2 (FFAR2) has been reported as a tumor suppressor in colon cancer development. The current study investigated the effects of FFAR2 signaling on energy metabolism and... -
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- Protocatechuic Acid, a Gut Bacterial Metabolite of Black Raspberries, Inhibits Adenoma Development and Alters Gut Microbiome Profiles in Apc Min/+ Mice
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Dong A, Lin CW, Echeveste CE, Huang YW, Oshima K, Yearsley M, Chen X, Yu J, Wang LS
- KMID: 2528091
- J Cancer Prev.
- 2022 Mar;27(1):50-57.
- doi: 10.15430/JCP.2022.27.1.50
Administration of black raspberries (BRBs) and their anthocyanin metabolites, including protocatechuic acid (PCA), has been demonstrated to exert chemopreventive effects against colorectal cancer through alteration of innate immune cell trafficking,... -
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- Anti-colonic Inflammation by Black Raspberries through Regulating Toll-like Receptor-4 Signaling in Interlukin-10 Knockout Mice
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Huang YW, Echeveste CE, Oshima K, Zhang J, Yearsley M, Yu J, Wang LS
- KMID: 2503568
- J Cancer Prev.
- 2020 Jun;25(2):119-125.
- doi: 10.15430/JCP.2020.25.2.119
Ulcerative colitis (UC) is a chronic inflammatory disease of the colon, with a steadily rising prevalence in Western and newly industrialized countries. UC patients have a cancer incidence as high... -
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- A Pilot Clinical Study to Investigate the Hypomethylating Properties of Freeze-dried Black Raspberries in Patients with Myelodysplastic Syndrome or Myeloproliferative Neoplasm
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Dong A, Pan X, Lin CW, Huang YW, Krause H, Pan P, Baim A, Thomas MJ, Chen X, Yu J, Michaelis L, Liu P, Wang LS, Atallah E
- KMID: 2531047
- J Cancer Prev.
- 2022 Jun;27(2):129-138.
- doi: 10.15430/JCP.2022.27.2.129
Myelodysplastic syndromes (MDS) and myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are bone marrow disorders characterized by cytopenias and progression to acute myeloid leukemia. Hypomethylating agents (HMAs) are Food and Drug Administration-approved therapies for... -
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