- Extracellular Vesicles and Neurological Diseases
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Ho DH, Seo H, Son I, Seol W
- KMID: 2184640
- J Korean Neurol Assoc.
- 2015 May;33(2):75-81.
- doi: 10.17340/jkna.2015.2.1
Extracellular vesicles (EVs) are small membranous vesicles that are secreted by various types of cells into biofluid or culture medium. EVs contain deoxyribonucleic acids, messenger ribonucleic acids (RNAs), microRNAs, lipids,... -
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- The Role of Autophagy Associated With Causative Genes for Parkinson's Disease
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Ho DH, Seo H, Son I, Seol W
- KMID: 2343520
- J Korean Neurol Assoc.
- 2014 Aug;32(3):137-144.
Parkinson's disease (PD) is the second most common neurodegenerative motor disorder, affecting approximately 1% of the population aged > or =60 years. Recent investigations have shown that in addition to... -
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- Unstable Repeat Expansion in Neurodegenerative Dementias: Mechanisms of Disease
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Yang HD, Ho DH, Seol W
- KMID: 2172260
- Dement Neurocogn Disord.
- 2012 Mar;11(1):1-12.
- doi: 10.12779/dnd.2012.11.1.1
The majority of neurodegenerative dementias are thought to result primarily from the misfolding, aggregation and accumulation of proteins which interfere with protein homeostasis in the brain. Some of them are... -
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- Misfolded Proteins in Neurodegenerative Dementias: Molecular Mechanisms
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Yang HD, Ho DH, Yi MJ, Seol W, Kim SY
- KMID: 2172233
- Dement Neurocogn Disord.
- 2012 Jun;11(2):38-52.
- doi: 10.12779/dnd.2012.11.2.38
During recent years, there has been remarkable progress with respect to the identification of molecular mechanisms and underlying pathology of neurodegenerative dementias. The latest evidence indicates that a common cause... -
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- Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers
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Lee HJ, Baek SM, Ho DH, Suk JE, Cho ED, Lee SJ
- KMID: 1104391
- Exp Mol Med.
- 2011 Apr;43(4):216-222.
- doi: 10.3858/emm.2011.43.4.026
Parkinson's disease (PD) is characterized by selective and progressive degeneration of dopamine (DA)-producing neurons in the substantia nigra pars compacta (SNpc) and by abnormal aggregation of alpha-synuclein. Previous studies have... -
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- LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation
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Ho DH, Je AR, Lee H, Son I, Kweon HS, Kim HG, Seol W
- KMID: 2416244
- Exp Neurobiol.
- 2018 Jun;27(3):171-180.
- doi: 10.5607/en.2018.27.3.171
Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease (PD). LRRK2 contains a functional kinase domain and G2019S, the most prevalent LRRK2 pathogenic mutation,... -
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- LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25
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Yun HJ, Park J, Ho DH, Kim H, Kim CH, Oh H, Ga I, Seo H, Chang S, Son I, Seol W
- KMID: 2154255
- Exp Mol Med.
- 2013 Aug;45(8):e36.
Leucine-rich repeat kinase 2 (LRRK2) is a gene that, upon mutation, causes autosomal-dominant familial Parkinson's disease (PD). Yeast two-hybrid screening revealed that Snapin, a SNAP-25 (synaptosomal-associated protein-25) interacting protein, interacts... -
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