- Arginine methylation as a key post-translational modification in skeletal muscle homeostasis: a review
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Kim H, Kang JS, Jeong HJ
- KMID: 2470434
- Precis Future Med.
- 2019 Dec;3(4):139-145.
- doi: 10.23838/pfm.2019.00107
Arginine methylation mediated by protein arginine methyltransferases (PRMTs) has emerged as a key post-translational modification of histone or nonhistone substrates. It involves or controls signaling pathways or gene expression implicated... -
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- Effects of β-carotene on Expression of Selected MicroRNAs, Histone Acetylation, and DNA Methylation in Colon Cancer Stem Cells
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Kim D, Kim Y, Kim Y
- KMID: 2468812
- J Cancer Prev.
- 2019 Dec;24(4):224-232.
- doi: 10.15430/JCP.2019.24.4.224
BACKGROUND: Beta-carotene (BC) is a carotenoid which exerts anti-cancer effects in several types of cancer, including colorectal cancer. Epigenetic modifications of genes, such as histone deacetylation and DNA hypermethylation, have... -
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- Response of Glucocorticoid Receptor Alpha and Histone Deacetylase 2 to Glucocorticoid Treatment Predicts the Prognosis of Sudden Sensorineural Hearing Loss
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Zhang X, Chen J, Gao Z, Qi H, Dai Y, She W
- KMID: 2462732
- Clin Exp Otorhinolaryngol.
- 2019 Nov;12(4):367-375.
- doi: 10.21053/ceo.2018.01298
OBJECTIVES: To investigate glucocorticoid receptor (GR) and histone deacetylase 2 (HDAC2) gene expression and protein levels in peripheral blood mononuclear cells (PBMCs) of patients with severe or profound sudden sensorineural... -
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- Proteomic Analysis on Exosomes Derived from Patients’ Sera Infected with Echinococcus granulosus
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Wang W, Zhou X, Cui F, Shi C, Wang Y, Men Y, Zhao W, Zhao J
- KMID: 2463736
- Korean J Parasitol.
- 2019 Oct;57(5):489-497.
- doi: 10.3347/kjp.2019.57.5.489
Cystic echinococcosis (CE), a zoonotic disease caused by Echinococcus granulosus at the larval stage, predominantly develops in the liver and lungs of intermediate hosts and eventually results in organ malfunction... -
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- RbAp48 expression and neuronal damage in the gerbil hippocampus following 5 min of transient ischemia
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Park JH, Lee TK, Kim DW, Park CW, Park YE, Kim B, Lee JC, Lee HA, Won MH, Ahn JH
- KMID: 2470111
- Lab Anim Res.
- 2019 Aug;35(2):78-85.
- doi: 10.1186/s42826-019-0011-3
Histone-binding protein RbAp48 has been known to be involved in histone acetylation, and epigenetic alterations of histone modifications are closely associated with the pathogenesis of ischemic reperfusion injury. In the... -
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- Downregulation of SIRT2 by Chronic Stress Reduces Expression of Synaptic Plasticity-related Genes through the Upregulation of Ehmt2
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Wang SE, Ko SY, Jo S, Jo HR, Han J, Kim YS, Son H
- KMID: 2458551
- Exp Neurobiol.
- 2019 Aug;28(4):537-546.
- doi: 10.5607/en.2019.28.4.537
Silent information regulator 2 (Sirtuin2 / SIRT2) is a NADâº-dependent deacetylase that regulates the cellular oxidative stress response. It modulates transcriptional silencing and protein stability through deacetylation of target proteins... -
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- HDAC Inhibition by Valproic Acid Induces Neuroprotection and Improvement of PD-like Behaviors in LRRK2 R1441G Transgenic Mice
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Kim T, Song S, Park Y, Kang S, Seo H
- KMID: 2458548
- Exp Neurobiol.
- 2019 Aug;28(4):504-515.
- doi: 10.5607/en.2019.28.4.504
Parkinson’s disease (PD) is one of the late-onset neurodegenerative movement disorder. Major pathological markers of PD include progressive loss of dopaminergic neurons, Lewy body formation, genetic mutations, and environmental factors.... -
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- Targeted Downregulation of kdm4a Ameliorates Tau-engendered Defects in Drosophila melanogaster
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Park SY, Seo J, Chun YS
- KMID: 2455488
- J Korean Med Sci.
- 2019 Aug;34(33):e225.
- doi: 10.3346/jkms.2019.34.e225
BACKGROUND: Tauopathies, a class of neurodegenerative diseases that includes Alzheimer's disease (AD), are characterized by the deposition of neurofibrillary tangles composed of hyperphosphorylated tau protein in the human brain. As... -
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- Genome Engineering for Osteoarthritis: From Designer Cells to Disease-Modifying Drugs
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Choi YR, Collins KH, Lee JW, Kang HJ, Guilak F
- KMID: 2455043
- Tissue Eng Regen Med.
- 2019 Aug;16(4):335-343.
- doi: 10.1007/s13770-018-0172-4
BACKGROUND: Osteoarthritis (OA) is a highly prevalent degenerative joint disease involving joint cartilage and its surrounding tissues. OA is the leading cause of pain and disability worldwide. At present, there... -
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- Angiotensin II and TGF-β1 Induce Alterations in Human Amniotic Fluid-Derived Mesenchymal Stem Cells Leading to Cardiomyogenic Differentiation Initiation
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GasiÅ«nienÄ— M, Petkus G, MatuzeviÄius D, Navakauskas D, NavakauskienÄ— R
- KMID: 2465896
- Int J Stem Cells.
- 2019 Jul;12(2):251-264.
- doi: 10.15283/ijsc18126
BACKGROUND AND OBJECTIVES: Human amniotic fluid-derived mesenchymal stem cells (AF-MSCs) may be a valuable source for cardiovascular tissue engineering and cell therapy. The aim of this study is to verify... -
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- 4′-O-β-D-Glucosyl-5-O-Methylvisamminol Attenuates Pro-Inflammatory Responses and Protects against Oxidative Damages
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Yoo OK, Keum YS
- KMID: 2455093
- Biomol Ther.
- 2019 Jul;27(4):381-385.
- doi: 10.4062/biomolther.2018.232
We attempted to examine anti-inflammatory and anti-oxidant effects of 4′-O-β-D-glucosyl-5-O-methylvisamminol (GOMV), the first epigenetic inhibitor of histone phosphorylation at Ser10. While GOMV did not affect the viability of murine macrophage... -
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- Free fatty acid-induced histone acetyltransferase activity accelerates lipid accumulation in HepG2 cells
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Chung S, Hwang JT, Park JH, Choi HK
- KMID: 2453283
- Nutr Res Pract.
- 2019 Jun;13(3):196-204.
- doi: 10.4162/nrp.2019.13.3.196
BACKGROUND/OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is a common metabolic disease triggered by epigenetic alterations, including lysine acetylation at histone or non-histone proteins, affecting the stability or transcription of lipogenic... -
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- Short-chain Fatty Acids Inhibit Staphylococcal Lipoprotein-induced Nitric Oxide Production in Murine Macrophages
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Park JW, Kim HY, Kim MG, Jeong S, Yun CH, Han SH
- KMID: 2444157
- Immune Netw.
- 2019 Apr;19(2):e9.
- doi: 10.4110/in.2019.19.e9
Staphylococcus aureus, a Gram-positive pathogen, can cause severe inflammation in humans, leading to various life-threatening diseases. The lipoprotein is a major virulence factor in S. aureus-induced infectious diseases and is... -
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- Suppressor of Variegation 3–9 Homolog 2, a Novel Binding Protein of Translationally Controlled Tumor Protein, Regulates Cancer Cell Proliferation
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Kim AR, Sung JY, Rho SB, Kim YN, Yoon K
- KMID: 2442016
- Biomol Ther.
- 2019 Feb;27(2):231-239.
- doi: 10.4062/biomolther.2019.021
Suppressor of Variegation 3–9 Homolog 2 (SUV39H2) methylates the lysine 9 residue of histone H3 and induces heterochromatin formation, resulting in transcriptional repression or silencing of target genes. SUV39H1 and... -
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- Isolation of MLL1 Inhibitory RNA Aptamers
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Ul-Haq A, Jin ML, Jeong KW, Kim HM, Chun KH
- KMID: 2442012
- Biomol Ther.
- 2019 Feb;27(2):201-209.
- doi: 10.4062/biomolther.2018.157
Mixed lineage leukemia proteins (MLL) are the key histone lysine methyltransferases that regulate expression of diverse genes. Aberrant activation of MLL promotes leukemia as well as solid tumors in humans,... -
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- Selective inhibition of histone deacetylase 8 improves vascular hypertrophy, relaxation, and inflammation in angiotensin II hypertensive mice
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Kee HJ, Ryu Y, Seok YM, Choi SY, Sun S, Kim GR, Jeong MH
- KMID: 2468620
- Clin Hypertens.
- 2019 ;25(1):13.
- doi: 10.1186/s40885-019-0118-8
BACKGROUND: The dysregulation of histone deacetylase (HDAC) protein expression or its enzyme activity is implicated in a variety of diseases. Cardiac HDAC6 and HDAC8 enzyme activity induced by deoxycorticosterone acetate... -
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- Dual mechanisms for the regulation of brain-derived neurotrophic factor by valproic acid in neural progenitor cells
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Ko HM, Jin Y, Park HH, Lee JH, Jung SH, Choi SY, Lee SH, Shin CY
- KMID: 2430090
- Korean J Physiol Pharmacol.
- 2018 Nov;22(6):679-688.
- doi: 10.4196/kjpp.2018.22.6.679
Autism spectrum disorders (ASDs) are neurodevelopmental disorders that share behavioral features, the results of numerous studies have suggested that the underlying causes of ASDs are multifactorial. Behavioral and/or neurobiological analyses... -
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- Development of a Novel Nonradioisotopic Assay and Cdc25B Overexpression Cell Lines for Use in Screening for Cdc25B Inhibitors
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Ha GS, Lee CM, Kim CW
- KMID: 2419735
- Yonsei Med J.
- 2018 Oct;59(8):995-1003.
- doi: 10.3349/ymj.2018.59.8.995
PURPOSE: The cyclin-dependent kinase 1 (Cdk1) and cyclin B complex performs important roles in the transition from the G2 to M phase in the cell cycle through removal of inhibitory... -
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- Links between Serine Biosynthesis Pathway and Epigenetics in Cancer Metabolism
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Kim H, Park YJ
- KMID: 2417711
- Clin Nutr Res.
- 2018 Jul;7(3):153-160.
- doi: 10.7762/cnr.2018.7.3.153
Cancer metabolism is considered as one of major cancer hallmarks. It is important to understand cancer-specific metabolic changes and its impact on cancer biology to identify therapeutic potentials. Among cancer-specific... -
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- Histone Deacetylase-3 Modification of MicroRNA-31 Promotes Cell Proliferation and Aerobic Glycolysis in Breast Cancer and Is Predictive of Poor Prognosis
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Zhao Y, He J, Yang L, Luo Q, Liu Z
- KMID: 2413929
- J Breast Cancer.
- 2018 Jun;21(2):112-123.
- doi: 10.4048/jbc.2018.21.2.112
PURPOSE: The incidence and mortality of breast cancer is increasing worldwide. There is a constant quest to understand the underlying molecular biology of breast cancer so as to plan better... -
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