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Histone lysine demethylases in mammalian embryonic development

Shen H, Xu W, Lan F

Post-translational modifications, such as methylation, acetylation and phosphorylation, of histone proteins play important roles in regulating dynamic chromatin structure. Histone demethylation has become one of the most active research areas...
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RBP2 induces stem-like cancer cells by promoting EMT and is a prognostic marker for renal cell carcinoma

Zhou D, Kannappan , Chen X, Li J, Leng X, Zhang J, Xuan S

Renal cell carcinoma (RCC), one of the most common kidney cancers, has a poor prognosis. Epithelial to mesenchymal transition (EMT) is a hallmark of carcinoma invasion and metastasis. Several studies...
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Epigenetic Role of Histone 3 Lysine Methyltransferase and Demethylase in Regulating Apoptosis Predicting the Recurrence of Atypical Meningioma

Lee SH, Lee EH, Lee SH, Lee YM, Kim HD, Kim YZ

Alteration of apoptosis is related with progression and recurrence of atypical meningiomas (AMs). However, no comprehensive study has been conducted regarding histone modification regulating apoptosis in AMs. This study aimed...
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