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Anti-fibrotic treatments for chronic liver diseases: The present and the future

Odagiri N, Matsubara T, Sato-Matsubara M, Fujii H, Enomoto M, Kawada N

Liver fibrosis reflects tissue scarring in the liver due to the accumulation of excessive extracellular matrix in response to chronically persistent liver injury. Hepatocyte cell death can trigger capillarization of...
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Inhibition of COX-2 Impairs Colon Cancer Liver Metastasis through Reduced Stromal Cell Reaction

Herrero A, Benedicto A, Romayor I, Olaso E, Arteta B

Liver colonization is initiated through the interplay between tumor cells and adhesion molecules present in liver sinusoidal endothelial cells (LSECs). This crosstalk stimulates tumor COX-2 upregulation and PGE 2 secretion....
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Irisin Regulates the Functions of Hepatic Stellate Cells

Dong HN, Park SY, Le CT, Choi DH, Cho EH

Background: Hepatic stellate cells (HSCs) are known to play a fundamental role in the progression of liver fibrosis. Once HSCs are activated, they are involved in proliferation, migration, and contractility...
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Role of cytoglobin, a novel radical scavenger, in stellate cell activation and hepatic fibrosis

Thuy LTT, Hai H, Kawada N

Cytoglobin (Cygb), a stellate cell-specific globin, has recently drawn attention due to its association with liver fibrosis. In the livers of both humans and rodents, Cygb is expressed only in...
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miR-140-3p Knockdown Suppresses Cell Proliferation and Fibrogenesis in Hepatic Stellate Cells via PTEN-Mediated AKT/mTOR Signaling

Wu SM, Li TH, Yun H, Ai HW, Zhang KH

PURPOSE: Liver fibrosis is a major cause of morbidity and mortality and the outcome of various chronic liver diseases. Activation of hepatic stellate cells (HSCs) is the key event in...
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Bone Marrow Stem Cells Anti-liver Fibrosis Potency: Inhibition of Hepatic Stellate Cells Activity and Extracellular Matrix Deposition

Sitanggang EJ, Antarianto RD, Jusman SW, Pawitan JA, Jusuf AA

Transplantation of bone marrow derived stem cells (BMSCs) has been reported inhibits liver fibrosis. Several in vitro studies by co-culturing BMSCs and hepatic stellate cells (HSCs) indirectly or directly in...
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Reversal of liver cirrhosis: current evidence and expectations

Jung YK, Yim HJ

In the past, liver cirrhosis was considered an irreversible phenomenon. However, many experimental data have provided evidence of the reversibility of liver fibrosis. Moreover, multiple clinical studies have also shown...
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The Role of Mesothelial Cells in Liver Development, Injury, and Regeneration

Lua I, Asahina K

Mesothelial cells (MCs) cover the surface of visceral organs and the parietal walls of cavities, and they synthesize lubricating fluids to create a slippery surface that facilitates movement between organs...
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Parthenolide-induced apoptosis of hepatic stellate cells and anti-fibrotic effects in an in vivo rat model

Kim IH, Kim SW, Kim SH, Lee SO, Lee ST, Kim DG, Lee MJ, Park WH

  • KMID: 1397449
  • Exp Mol Med.
  • 2012 Jul;44(7):448-456.
Parthenolide (PT), a sesquiterpene lactone derived from the plant feverfew, has pro-apoptotic activity in a number of cancer cell types. We assessed whether PT induces the apoptosis of hepatic stellate...
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Antifibrotic effects of magnesium lithospermate B on hepatic stellate cells and thioacetamide-induced cirrhotic rats

Paik YH, Yoon YJ, Lee HC, Jung MK, Kang SH, Chung SI, Kim JK, Cho JY, Lee KS, Han KH

Magnesium lithospermate B (MLB) is one of the major active components of Salvia miltiorrhizae. The anti-oxidative effects of Salvia miltiorrhizae have been previously reported. The aim of this study was...
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Transcriptional profiling and Wnt signaling activation in proliferation of human hepatic stellate cells induced by PDGF-BB

Shin H, Park SY, Lee KB, Shin E, Nam SW, Lee JY, Jang JJ

BACKGROUND/AIMS: This study aimed to better understand gene expression profiles of human hepatic stellate cell (HSC) activation and the relationship with the Wnt signaling pathway. METHODS: The global transcript levels...
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Changes in Inward Rectifier K+ Channels in Hepatic Stellate Cells During Primary Culture

Lee DH, Kong ID, Lee JW, Park KS

PURPOSE: This study examined the expression and function of inward rectifier K+ channels in cultured rat hepatic stellate cells (HSC). MATERIALS AND METHODS: The expression of inward rectifier K+ channels...
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Heterogeneous Composition of Voltage-Dependent K+ Currents in Hepatic Stellate Cells

Lee DH, Kimm K, Kim HL, Han BG

PURPOSE: Hepatic stellate cells (HSC) are a type of pericyte with varying characteristics according to their location. However, the electrophysiological properties of HSC are not completely understood. Therefore, this study...
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Characteristics of Potassium and Calcium Currents of Hepatic Stellate Cells (Ito) in Rat

Lee KI, Kong ID, Baik SK, Kim HS, Lee DK, Kwon SO, Chun BG

Hepatic stellate cells (HSCs) are known to play a role in the pathogenesis of the increased intrahepatic vascular resistance found in chronic liver diseases. The aim of this study was...
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Role of Hepatic Stellate Cells in the Angiogenesis of Hepatoma

Jung JO, Gwak GY, Lim YS, Kim CY, Lee HS

  • KMID: 772536
  • Korean J Gastroenterol.
  • 2003 Aug;42(2):142-148.
BACKGROUND/AIMS: Hepatic stellate cells (HSCs) in the hepatocellular carcinoma are responsible for tumor encapsulation as a host defense mechanism. Recently, it was suggested that HSCs might play an important...
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