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The prevalence and risk factors of inhibitor development of FVIII in previously treated patients with hemophilia A

Kim JY, You CW

BACKGROUND: Risk factors for the development of inhibitors in previously untreated patients (PUPs) have been reported; this is not the case in previously treated patients (PTPs) owing to fewer studies....
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Subgroup analysis of a phase 2/3 study of rurioctocog alfa pegol in patients with severe hemophilia A: efficacy and safety in previously treated Korean patients

You CW, Baek HJ, Park SK, Park YS, Shin HJ, Engl W, Tangada S

BACKGROUND: The efficacy and safety of extended half-life, full-length, pegylated recombinant factor VIII rurioctocog alfa pegol [BAX 855, ADYNOVATE (USA)/ADYNOVI (Europe); Baxalta US Inc., a Takeda company, Lexington, MA, USA]...
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The Effectiveness of Interventional Trans-Arterial Embolization to Control Active Bleeding Before Medical Treatment in Patients with Acquired Hemophilia Presenting as Retroperitoneal Hematoma and Hemothorax: A Case Report

Kim DK

The author report a case involving a 60-year-old man with acquired hemophilia who presented with sudden-onset left abdominal pain and exhibited retroperitoneal hematoma and hemothorax. In the long term, the...
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Various Complications after a Vascular Procedure in Patients with Hemophilia

Ha YS, Park YS

Hemophilia, an inherited bleeding disorder, is caused by a deficiency of coagulation factor VIII or IX. Most of patients with hemophilia need vascular procedure, which can lead to complications. Even...
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A Multicenter Study on von Willebrand Disease Realities in Yeungnam Region

Kim HJ, Shim YJ, Lee JM, Lim YT, Yang EJ, Park KM, Chueh HW, Park ES, Kim HS, Park JK, Choi EJ, Kong SG, Kim JY, Park SK

BACKGROUND: von Willebrand disease (VWD) is one of the most common inherited bleeding disorders. However, the number of patients who register to the Korea Hemophilia Foundation (KHF) is much lower...
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Acquired Hemophilia in a Patient Presenting with Swollen Left Limb

Kiam GW

Acquired hemophilia is a rare, potentially life-threatening disease that usually remains under-recognized especially in a primary setting; thus, diagnosing this disease is very challenging. Given its prevalence in elderly patients,...
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Hemophilia A in a Female Patient with Recurrent Vitreous Hemorrhage

Kim HJ, Nam MS, Choo HK, Kim SH

PURPOSE: To report a case of recurrent intraocular hemorrhage due to type A hemophilia in a female patient without any previous medical history. CASE SUMMARY: A 51-year-old female patient without any...
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Spontaneous Retroperitoneal Hemorrhage Caused by Idiopathic Acquired Hemophilia A Misdiagnosed as a Delayed Traumatic Hematoma: A Case Report

Kim SH, Park SJ, Park CI, Choi SU, Kim JH

Acquired hemophilia A (AHA) is a rare disease where typically coagulation factor VIII is inhibited by autoantibodies. It occurs in patients with no personal or familial history of bleeding. In...
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Ultrasound-Guided Botulinum Toxin Injection with Factor VIII Administration for Post Stroke Spasticity in a Hemophilia A Patient

Shin MA, Lee SH, Lee JM, Shin JH

Chemodenervation with botulinum toxin (BTX) has been recommended for focal spasticity. BTX injection should be performed with caution in patients with bleeding disorders and/or receiving anticoagulation therapy. We present a...
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A Case of Hemophilia B Diagnosed after Rhinosinus Surgery in 37 Year-Old Patient

Kim HD, Choi IS

Hemophilia is an X-linked recessive disorder, which is classified into hemophilia A, defined by factor VIII deficiency and hemophilia B, defined by factor IX deficiency. The usual clinical presentation is...
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Perioperative Management of Patients with Hemophilia during Spinal Surgery

Kobayashi , Imagama S, Ando K, Ito K, Tsushima M, Morozumi M, Tanaka S, Machino M, Ota K, Nishida Y, Ishiguro N

STUDY DESIGN: Single-center retrospective study. PURPOSE: To optimize the perioperative management of patients with hemophilia who are undergoing spinal surgery. OVERVIEW OF LITERATURE: Hemophilia is a rare disease in which there is...
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Clinical and Radiological Evaluation After Chemical Synovectomy With Rifampicin in Hemophilic Arthropathy: Korean Experience With a 2-Week Interval Protocol

Suh HC, Kim DK, Kang SH, Seo KM, Kim HS, Lee JY, Lee SY, Yoo KY

OBJECTIVE: To assess the clinical outcome of chemical synovectomy with rifampicin in hemophilic arthropathy by using the World Federation of Hemophilia (WFH) scoring system and plain radiograph. METHODS: We performed rifampicin...
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A case report spontaneous spinal epidural hematoma diagnosed in a hemophilic child with neck pain

Lee HJ

Hemophilia is a disease that causes a hemorrhagic tendency due to a congenital deficiency of blood clotting factors. Hemorrhagic arthritis is the most common complication in hemophilia patients, and hemorrhage...
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Septic Arthritis and Infective Endocarditis in an Adolescent Hemophilia B Patient with an Inhibitor and a Central Venous Access Device

Kim J, Park YS

Central venous access devices (CVAD) provide hemophilic patients, particularly children, with prolonged reliable venous access to promote routine factor replacement therapy. However, one of the significant complications of CVAD use...
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Educational Interventions to Enhance Adherence to Prophylactic Treatment in Korean Hemophilia Patients

Na JH, Yoo KY, Kim JY, Park SK, Kim SK, Choi EJ

BACKGROUND: A patient's adherence to prophylactic treatment is one of the most significant factors to achieve desired outcomes, in regards to the quality of life and treatment cost-effectiveness. The aim...
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Progress of Hemophilia A Therapeutics in Korea

Kim DH, Kim SK

Over the past several decades, hemophilia treatment in Korea has progressed dramatically. It has become possible to prevent hemophilia complications by maintenance treatment as well as on-demand treatment with the...
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Global hemostatic assay of different target procoagulant activities of factor VIII and factor IX

Yoo KY, Jung SY, Hwang SH, Lee SM, Park JH, Nam HJ

BACKGROUND: Korean National Health Insurance reimburses factor VIII (FVIII) and factor IX (FIX) clotting factor concentrate (CFC) infusions to discrepant activity levels, allowing elevation of FVIII activity to 60 IU/dL...
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Price of PRICE (Protection, Rest, Ice, Compression, and Elevation) redefined: a case of entrapment neuropathy in an individual with hemophilia

Patra PC, Mandal PK, Gantait D, Bhowmik A, Chakrabarti P

No abstract available.
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Management of Spontaneous Spinal Epidural Hematoma Developed in Children with Hemophilia

Jang HN, Yoon HS, Park YS

Spinal epidural hematoma (SEH) is a rare neurosurgical emergency in which pressure on the spinal cord leads to acute neurological deficits, and is a rare complication in children with hemophilia....
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Joint Health Status in Hemophilia Patients Using Hemophilia Joint Health Score and Pettersson Score

Roh YY, Choi YH, Park M, Hahn JH, Kim SH, Shin YJ, Hahn SM, Lee HY, Park JM, Hong JP, Lyu CJ, Han JW

BACKGROUND: Comprehensive clinical and radiologic follow-up is needed to preserve joint functions and quality of life in hemophilia using clinimetric tools such as Hemophilia joint health score (HJHS) or Pettersson...
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