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Possible Involvement of Keratinocyte Growth Factor in the Persistence of Hyperpigmentation in both Human Facial Solar Lentigines and Melasma

Hasegawa K, Fujiwara R, Sato K, Shin J, Kim SJ, Kim M, Kang HY

No abstract available.
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Pazopanib as a second line treatment for uterine and ovarian carcinosarcoma: a single institutional study

Nishikawa , Hasegawa K, Yabuno A, Yoshida H, Yasuda M, Kozawa E, Fujiwara K

No abstract available.
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Evaluation of Circulating Tumor DNA in Patients with Ovarian Cancer Harboring Somatic PIK3CA or KRAS Mutations

Ogasawara A, Hihara T, Shintani D, Yabuno A, Ikeda Y, Tai K, Fujiwara K, Watanabe K, Hasegawa K

Purpose Circulating tumor DNA (ctDNA) is an attractive source for liquid biopsy to understand molecular phenotypes of a tumor non-invasively, which is also expected to be both a diagnostic and prognostic...
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Use of a right lateral sector graft in living donor liver transplantation

Hayakawa T, Kokudo, T, Kawaguchi Y, Kaneko J, Arita J, Akamatsu N, Hasegawa K

Background: Living donor liver transplantation (LDLT) is performed more frequently than deceased donor liver transplantation (DDLT) in Asian countries. Our group firstly reported the usage of right lateral sector graft...
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Cervical Inclination Angle: Normative Values in an Adult Multiethnic Asymptomatic Population

Huec JCL, Sardar ZM, Quarto E, Cerpa M, Kelly MP, Hasegawa K, Dennis Hey HW, Wong HK, Riahi H, Lenke LG, Bourret S, MEANS study group

Objective: The role of the craniocervical complex in spinal sagittal alignment has rarely been analyzed but it may play a fundamental role in postoperative mechanical complications. The aim of the...
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High expression of maternal embryonic leucine-zipper kinase (MELK) impacts clinical outcomes in patients with ovarian cancer and its inhibition suppresses ovarian cancer cells growth ex vivo

Ikeda Y, Sato S, Yabuno A, Shintani D, Ogasawara A, Miwa M, Zewde M, Miyamoto T, Fujiwara K, Nakamura Y, Hasegawa K

Objective: Maternal embryonic leucine zipper kinase (MELK) is receiving an attention as a therapeutic target in various types of cancers. In this study, we aimed to evaluate the prognostic significance...
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Japan Society of Gynecologic Oncology 2018 guidelines for treatment of uterine body neoplasms

Yamagami W, Mikami M, Nagase S, Tabata T, Kobayashi Y, Kaneuchi M, Kobayashi H, Yamada H, Hasegawa K, Fujiwara H, Katabuchi H, Aoki D

The Fourth Edition of the Guidelines for Treatment of Uterine Body Neoplasm was published in 2018. These guidelines include 9 chapters: 1. Overview of the guidelines, 2. Initial treatment for...
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Clinical utility of CA-125 in the management of uterine carcinosarcoma

Matsuo K, Ross MS, Yunokawa M, Johnson MS, Machida H, Omatsu K, Klobocista MM, Im DD, Satoh S, Baba T, Ikeda Y, Bush SH, Hasegawa K, Blake EA, Takekuma M, Shida M, Nishimura , Adachi S, Pejovic T, Takeuchi S, Yokoyama T, Ueda Y, Iwasaki K, Miyake TM, Yanai S, Nagano T, Takano T, Shahzad MM, Ueland FR, Kelley JL, Roman LD

No abstract available.
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The Posterior Cranial Vertical Line: A Novel Radiographic Marker for Classifying Global Sagittal Alignment

Park PJ, Hassan FM, Ferrer XE, Morrissette C, Lee NJ, Cerpa M, Sardar ZM, Kelly MP, Bourret S, Hasegawa K, Wong HK, Liu G, Hey HWD, Riahi H, Huec JCL, Lenke LG

Objective: To define a novel radiographic measurement, the posterior cranial vertical line (PCVL), in an asymptomatic adult population to better understand global sagittal alignment. Methods: We performed a multicenter retrospective review...
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En Bloc Spondylectomy for Spinal Metastases: Detailed Oncological Outcomes at a Minimum of 2 Years after Surgery

Ohashi M, Hirano T, Watanabe K, Hasegawa K, Ito T, Katsumi K, Shoji H, Mizouchi T, Takahashi , Homma T, Endo N

STUDY DESIGN: Retrospective case series. PURPOSE: To investigate the oncological outcomes, including distant relapse, after en bloc spondylectomy (EBS) for spinal metastases in patients with a minimum of 2-year follow-up. OVERVIEW OF...
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Phase 2 single-arm study on the safety of maintenance niraparib in Japanese patients with platinum-sensitive relapsed ovarian cancer

Takehara K, Matsumoto T, Hamanishi J, Hasegawa K, Matsuura M, Miura K, Nagao S, Nakai H, Tanaka N, Tokunaga H, Ushijima K, Watari H, Yokoyama Y, Kase Y, Sumino S, Suri A, Itamochi H, Takeshima N

Objective: The primary objective of this study was to evaluate the safety of niraparib 300 mg/day in Japanese patients with platinum-sensitive, relapsed ovarian cancer in a maintenance setting. Methods: Phase 2,...
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Phase 2 single-arm study on the efficacy and safety of niraparib in Japanese patients with heavily pretreated, homologous recombination-deficient ovarian cancer

Okamoto A, Kondo E, Nakamura T, Yanagida S, Hamanishi J, Harano K, Hasegawa K, Hirasawa T, Hori K, Komiyama S, Matsuura M, Nakai H, Nakamura H, Sakata J, Tabata T, Takehara K, Takekuma M, Yokoyama Y, Kase Y, Sumino S, Soeda J, Suri A, Aoki D, Sugiyama T

Objective: To evaluate the efficacy and safety of niraparib in Japanese women with heavily pretreated ovarian cancer. Methods: This Phase 2 open-label, single-arm study enrolled Japanese women with homologous recombination deficiency-positive...
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