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Locacorten Vioform Ototoxicity Upon Guinea Pig Middle Ear Application

Woods O, Saliba I

BACKGROUND AND OBJECTIVES: Locacorten Vioform (Novartis UK) is frequently prescribed for otomycosis. Its component, Clioquinol, also has anti-bacterial properties. Up to this point, its ototoxic potential has not been evaluated....
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Apoptosis Progression in the Hair Cells in the Organ of Corti of GJB2 Conditional Knockout Mice

Zhang Y, Zhang X, Li L, Sun Y, Sun J

OBJECTIVES: Apoptosis may play an important role in the mechanism underlying the GJB2 gene conditional knockout (cCx26) mice cochlear cell death. The objective of this study was to explore the...
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Valuation of Transient Evoked Otoacoustic Emissions and Distortion Product Otoacoustic Emissions in Tinnitus Patients with Normal Hearing

Kim JT, Lee HS, Lee HR, Choi HS, Lee BD, Hwang K

BACKGROUND AND OBJECTIVES: This study aims to verify that one of the causes of tinnitus is the malfunction of outer hair cells and, on the basis of this, to investigate...
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Inhibition of K⁺ outward currents by linopirdine in the cochlear outer hair cells of circling mice within the first postnatal week

Kang SW, Ahn JW, Ahn SC

Inhibition of K⁺ outward currents by linopirdine in the outer hair cells (OHCs) of circling mice (homozygous (cir/cir) mice), an animal model for human deafness (DFNB6 type), was investigated using...
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ROS Scavenger, Ebselen, Has No Preventive Effect in New Hearing Loss Model Using a Cholesterol-Chelating Agent

Lee MY, Kabara LL, Swiderski , Raphael Y, Duncan RK, Kim YH

BACKGROUND AND OBJECTIVES: The antioxidant ebselen will be able to limit or prevent the ototoxicity arising from 2-hydroxypropyl-β-cyclodextrin (HPβCD). Niemann-Pick Type C (NPC) disease is a disorder of lysosomal storage...
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Hearing Improvement in A/J Mice via the Mouse Nerve Growth Factor

Gao L, Ge R, Xie G, Yao D, Li P, Wang O, Ma X, Han F

OBJECTIVES: To investigate the otoprotective effects of mouse nerve growth factor (mNGF) in A/J mice. METHODS: The mice at postnatal day 7 (P7) were randomly separated into a mNGF treated group...
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