- Increased Serum High Mobility Group Box 1 (HMGB1) Concentration and the Altered Expression of HMGB1 and Its Receptor Advanced Glycation Endproducts in Pemphigus
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Li JY, Lu YH, Zhang LW, Zhou PM, Chen T
- KMID: 2368046
- Ann Dermatol.
- 2017 Feb;29(1):121-123.
- doi: 10.5021/ad.2017.29.1.121
No abstract available. -
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- Extracellular HMGB1 Released after Zinc-treatment Induces Neuronal Death in Primary Cortical Cultures
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Lim CM, Kim JB, Lee JK
- KMID: 2092922
- Korean J Anat.
- 2008 Mar;41(1):89-96.
As a nonhistone DNA-binding protein, high mobility group box 1 (HMGB1) is released in large amounts into the extracellular space immediately after ischemic insult and plays a role in the... -
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- HMGB1-Binding Heptamer Confers Anti-Inflammatory Effects in Primary Microglia Culture
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Kim ID, Lee JK
- KMID: 2284633
- Exp Neurobiol.
- 2013 Dec;22(4):301-307.
- doi: 10.5607/en.2013.22.4.301
High mobility group box 1 (HMGB1) is an endogenous danger signal molecule. In the postischemic brain, HMGB1 is massively released during NMDA-induced acute damage and triggers inflammatory processes. In a... -
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- The Role of High Mobility Group Box 1 in Innate Immunity
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Lee SA, Kwak MS, Kim S, Shin JS
- KMID: 1799478
- Yonsei Med J.
- 2014 Sep;55(5):1165-1176.
- doi: 10.3349/ymj.2014.55.5.1165
With growing accounts of inflammatory diseases such as sepsis, greater understanding the immune system and the mechanisms of cellular immunity have become primary objectives in immunology studies. High mobility group... -
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- Increase in the Level of Proinflammatory Cytokine HMGB1 in Nasal Fluids of Patients With Rhinitis and its Sequestration by Glycyrrhizin Induces Eosinophil Cell Death
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Cavone L, Cuppari C, Manti S, Grasso L, Arrigo T, Calamai L, Salpietro , Chiarugi A
- KMID: 2360782
- Clin Exp Otorhinolaryngol.
- 2015 Jun;8(2):123-128.
- doi: 10.3342/ceo.2015.8.2.123
OBJECTIVES: The nuclear protein high mobility group protein box 1 (HMGB1) is a proinflammatory mediator that belongs to the alarmin family of proinflammatory mediators, and it has recently emerged as... -
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- Current Understanding of HMGB1-mediated Autophagy
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Kwak MS, Shin JS
- KMID: 2168685
- J Bacteriol Virol.
- 2013 Jun;43(2):148-154.
- doi: 10.4167/jbv.2013.43.2.148
Reactive oxygen species (ROS) is an oxidative stress to which cells respond by activating various defense mechanisms or cell death. Autophagy associated with oxidative stress response is a process to... -
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- Eosinophils Modulate CD4+ T Cell Responses via High Mobility Group Box-1 in the Pathogenesis of Asthma
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Shim EJ, Chun E, Lee HS, Bang BR, Cho SH, Min KU, Park HW
- KMID: 2365548
- Allergy Asthma Immunol Res.
- 2015 Mar;7(2):190-194.
- doi: 10.4168/aair.2015.7.2.190
Eosinophils have been reported to modulate T cell responses. Previously, we reported that high-mobility group box 1 protein (HMGB1) played a key role in the pathogenesis of asthma. This study... -
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- Calcium/Calmodulin-Dependent Protein Kinase is Involved in the Release of High Mobility Group Box 1 Via the Interferon-beta Signaling Pathway
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Ma L, Kim SJ, Oh KI
- KMID: 2424209
- Immune Netw.
- 2012 Aug;12(4):148-154.
Previously, we have reported that high mobility group box 1 (HMGB1), a proinflammatory mediator in sepsis, is released via the IFN-beta-mediated JAK/STAT pathway. However, detailed mechanisms are still unclear. In... -
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- The Role of HMGB1 and the Effect of Ethyl Pyruvate on Ischemia and Reperfusion Injury of Rat Kidney
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Chung KY, Park JJ, Kim YS
- KMID: 2201877
- J Korean Soc Transplant.
- 2007 Dec;21(2):234-240.
PURPOSE: High mobility group box-1 (HMGB1) was identified as a DNA binding protein that functions as a co-factor for proper transcriptional regulation in somatic cells. Extra- cellular HMGB1 acts as... -
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- Kinetics of HMGB1 level changes in a canine endotoxemia model
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Yu DH, Park J
- KMID: 1991805
- Korean J Vet Res.
- 2011 Sep;51(3):239-241.
In this study, we investigated the kinetics of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and high mobility group box 1 (HMGB1) concentrations in a 48-h model of canine endotoxemia by... -
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- Down-Regulation of Serum High-Mobility Group Box 1 Protein in Patients with Pulmonary Tuberculosis and Nontuberculous Mycobacterial Lung Disease
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Kim SY, Koh WJ, Park HY, Jeon K, Lee SY, Yim JJ, Shin SJ
- KMID: 2375984
- Tuberc Respir Dis.
- 2017 Apr;80(2):153-158.
- doi: 10.4046/trd.2017.80.2.153
BACKGROUND: Recently, increased levels of high-mobility group box 1 protein (HMGB1) have been identified in various inflammatory conditions and infections. However, no studies have evaluated the HMGB1 level in nontuberculous... -
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- Extracellular High-Mobility Group Box 1 is Increased in Patients with Behcet's Disease with Intestinal Involvement
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Ahn JK, Cha HS, Bae EK, Lee J, Koh EM
- KMID: 1777874
- J Korean Med Sci.
- 2011 May;26(5):697-700.
- doi: 10.3346/jkms.2011.26.5.697
High-mobility group box 1 (HMGB1) protein has been demonstrated to play an important role in chronic inflammatory diseases including rheumatoid arthritis, and systemic lupus erythematosus. This study investigated the association... -
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- Toll-like receptor 4 on islet beta cells senses expression changes in high-mobility group box 1 and contributes to the initiation of type 1 diabetes
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Li M, Song L, Gao X, Chang W, Qin X
- KMID: 1365903
- Exp Mol Med.
- 2012 Apr;44(4):260-267.
- doi: 10.3858/emm.2012.44.4.021
Type 1 diabetes mellitus is caused by the autoimmune destruction of beta cells within the islets. In recent years, innate immunity has been proposed to play a key role in... -
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- Proinflammatory Effects of High Mobility Group B1 (HMGB1) Versus LPS and the Mechanism of IL-8 Promoter Stimulation by HMGB1
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Jeon EJ, Kwak HW, Song JH, Lee YW, Chung JW, Choi JC, Shin JW, Park IW, Choi BW, Kim JY
- KMID: 1970230
- Tuberc Respir Dis.
- 2007 Apr;62(4):299-307.
- doi: 10.4046/trd.2007.62.4.299
BACKGROUND: High mobility group box 1 (HMGB1) is a novel, late mediator of inflammation. This study compared the pro-inflammatory effects of LPS and HMGB1. The transcriptional factors that play an... -
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- The Effects of Remifentanil on Expression of High Mobility Group Box 1 in Septic Rats
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Seo KH, Choi JW, Jung HS, Yoo H, Joo JD
- KMID: 2366654
- J Korean Med Sci.
- 2017 Mar;32(3):542-551.
- doi: 10.3346/jkms.2017.32.3.542
High mobility group box 1 (HMGB1) is a pivotal mediator of sepsis progression. Remifentanil, an opioid agonist, has demonstrated anti-inflammatory effects in septic mice. However, it is not yet known... -
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- Dimethyl Cardamonin Exhibits Anti-inflammatory Effects via Interfering with the PI3K-PDK1-PKCalpha Signaling Pathway
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Yu WG, He H, Yao JY, Zhu YX, Lu YH
- KMID: 2380306
- Biomol Ther.
- 2015 Nov;23(6):549-556.
- doi: 10.4062/biomolther.2015.048
Consumption of herbal tea [flower buds of Cleistocalyx operculatus (Roxb.) Merr. et Perry (Myrtaceae)] is associated with health beneficial effects against multiple diseases including diabetes, asthma, and inflammatory bowel disease.... -
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- Ameliorative Effects of Nilotinib on CCl4 Induced Liver Fibrosis Via Attenuation of RAGE/HMGB1 Gene Expression and Oxidative Stress in Rat
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Khanjarsim V, Karimi J, Khodadadi , Mohammadalipour A, Goodarzi M, Solgi G, Hashemnia
- KMID: 2379284
- Chonnam Med J.
- 2017 May;53(2):118-126.
- doi: 10.4068/cmj.2017.53.2.118
Nilotinib as a tyrosine kinase inhibitor has been recently used to improve the liver fibrosis process, but the exact mechanisms still require further clarification. In this study, we investigated the... -
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- Sepsis Mortality in CIITA Deficient Mice is Associated with Excessive Release of High-mobility Group Box 1
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Kim JY, Kim JH, Seo JN, Oh KI
- KMID: 1484312
- Immune Netw.
- 2008 Jun;8(2):39-45.
- doi: 10.4110/in.2008.8.2.39
BACKGROUND: Down regulation of major histocompatibility complex class II transactivator (CIITA) has been identified as a major factor of immunosuppression in sepsis and the level of CIITA expression inversely correlates... -
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- Toll-like Receptor 2: A Novel Therapeutic Target for Ischemic White Matter Injury and Oligodendrocyte Death
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Choi JY, Kim BG
- KMID: 2389005
- Exp Neurobiol.
- 2017 Aug;26(4):186-194.
- doi: 10.5607/en.2017.26.4.186
Despite paramount clinical significance of white matter stroke, there is a paucity of researches on the pathomechanism of ischemic white matter damage and accompanying oligodendrocyte (OL) death. Therefore, a large... -
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- Fluconazole Therapy for 5 cases of Cryptococcal Meningitis
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Kim JY, Suk SH, Huh K
- KMID: 2342414
- J Korean Neurol Assoc.
- 1994 Jun;12(2):358-362.
Cryptococcal meningitis is a relatively common central nervous system infection by Cryptococcus neoformans. Before the introduction of amphotericin B in 1956, cryptococcal infection of the central nervous system had been... -
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