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Prevalence, Risk Factors, and Expression of Human Leukocyte Antigen-DRB1 in Juvenile Idiopathic Arthritis-associated Uveitis

Pyo JK, Lee S, Kim KN

OBJECTIVE: This study investigated the prevalence and risk factors of juvenile idiopathic arthritis (JIA)-associated uveitis (JIA-U) in a pediatric tertiary center in Korea. In addition, this study examined whether a...
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Frequency and Distinct Characteristics of Acute Myeloid Leukemia Lacking HLA-DR and CD34 Expression: Features Intermediate between Typical Acute Myeloid Leukemia and Acute Promyelocytic Leukemia

Lee HY, Cho YU, You E, Jang S, Seo EJ, Park CJ

BACKGROUND: The objective of this study was to investigate the frequency and characteristics of HLA-DR⁻/CD34⁻ acute myeloid leukemia (AML) also known as acute promyelocytic leukemia (APL)-like AML. METHODS: This study included...
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Human Leukocyte Antigen-DRB1 Associations in Korean Juvenile Rheumatoid Arthritis

Lee CJ, Sohn TY, Lee DH, Lee HR, Kim M, Kim KN

OBJECTIVE: The aim of this study is to investigate the association of different subgroups of juvenile rheumatoid arthritis (JRA) with human leukocyte antigen (HLA) class II DR alleles. METHODS: One hundred...
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Recurrent Insulin Autoimmune Syndrome Caused by alpha-Lipoic Acid in Type 2 Diabetes

Bae SM, Bae MN, Kim EY, Kim IK, Seo MW, Shin JK, Cho SR, Jeong GH

Insulin autoimmune syndrome (IAS) is characterized by spontaneous hypoglycemia caused by insulin autoantibodies in the absence of exogenous insulin administration. Some drugs containing sulfhydryl compounds are known to initiate the...
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Role of Citrullinated Fibrinogen Peptides in the Activation of CD4 T Cells from Patients with Rheumatoid Arthritis

Shin K, Hong S, Choi EH, Lim MK, Shim SC, Ju JH, Lee SH

This study was conducted to determine whether CD4 T cell responses to citrullinated fibrinogen occur in patients with rheumatoid arthritis (RA), especially in HLA-DR4-positive subjects. Whole peripheral blood mononuclear cells...
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The HLA-DRB1 Polymorphism is Associated With Atopic Dermatitis, but not Egg Allergy in Korean Children

Park H, Ahn K, Park MH, Lee SI

PURPOSE: We investigated whether particular HLA-DRB1 polymorphisms contribute to egg allergy development in Korean children with atopic dermatitis (AD). METHODS: HLA-DRB1 alleles were determined by PCR-sequence-specific oligonucleotide (SSO) and PCR-single-strand conformation...
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HLA-DRB1 Study of DNA from Ancient Human Skeleton by Sequence-based Typing

Woo JY, Kim K, Munkhtsetseg B, Kim JH, Lkhagvasuren G, Sohn DS, Park AJ, Lee KH, Kim DJ, Chung YH, Kim SS, Lee WB, Kim KY

  • KMID: 1462541
  • Korean J Phys Anthropol.
  • 2010 Jun;23(2):49-60.
The analysis of ancient human DNA is increasingly used recently in the study of anthropology and human evolution. Although mitochondrial DNA and Y chromosomal DNA has commonly been the target...
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Clinical Spectrum and Prognostic Factors of Acute Necrotizing Encephalopathy in Children

Seo HE, Hwang SK, Choe BH, Cho MH, Park SP, Kwon S

This study was conducted to investigate the etiology, the clinical characteristics and prognosis of acute necrotizing encephalopathy (ANE) in Korean children. Six children (1 yr to 7 yr) patients with...
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Association of HLA-DR and -DQ Genes with Familial Moyamoya Disease in Koreans

Hong SH, Wang KC, Kim SK, Cho BK, Park MH

OBJECTIVE: Moyamoya disease (MMD) is an uncommon cerebrovascular disorder, characterized by progressive occlusion at the terminal portion of the internal carotid artery. Incidence of the disease is high in East...
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The Effect of Pretransplantation Fetomaternal Microchimerism Detected in Peripheral Blood on Graft Survival in Renal Transplantation

Joo SY, Shin Y, Song EY, Ha J, Kim S, Park MH

  • KMID: 2324144
  • J Korean Soc Transplant.
  • 2009 Jun;23(1):52-57.
BACKGROUND: Microchimerism detected after solid organ transplatnation has been reported to be associated with improved graft survival with some controversies. However, the effect of pretransplantation microchimerism on the graft survival...
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A case of insulin autoimmune syndrome related to alpha-lipoic acid

Chang HJ, Choi HS, Park MY, Leem SM, Jang YS, Park KS, Lee JM

  • KMID: 2257626
  • Korean J Med.
  • 2009 May;76(5):600-604.
Insulin autoimmune syndrome is characterized by spontaneous hypoglycemia, high concentrations of serum immunoreactive insulin, and the presence of autoantibodies to insulin without previous insulin injection. A 71-year-old woman with diabetes,...
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Allele and Haplotype Frequencies of Human Leukocyte Antigen-A, -B, and -DR Loci in Koreans: DNA Typing of 1,500 Cord Blood Units

Whang DH, Yang YS, Hong HK

BACKGROUND: The HLA system is known to be the most polymorphic genetic system in human, and HLA allele and haplotype distribution varies widely among different ethnic groups. This study was...
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The Expression of C4d and HLA-DR in Renal Allografts with the Histologic Features of Antibody-Mediated Rejection

Song YS, Park MH

  • KMID: 1163214
  • Korean J Pathol.
  • 2008 Oct;42(5):260-269.
BACKGROUND: Deposition of C4d along the peritubular capillaries is generally associated with an antibody-mediated response. We evaluated, with performing C4d immunostaining, the diagnostic accuracy of the cases that were previously...
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Meta-analysis of the Association between HLA-DRB1 Allele and Rheumatoid Arthritis Susceptibility in Asian Populations

Jun KR, Choi SE, Cha CH, Oh HB, Heo YS, Ahn HY, Lee KJ

The aims of this study were to summarize results on the association of HLA-DRB1 with rheumatoid arthritis (RA) in Asians and to determine if the shared epitope (SE) hypothesis could...
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Characteristics of Acute Myeloid Leukemia without HLA-DR Expression

Moon H, Lee S, Huh J, Chung WS

BACKGROUND: HLA-DR negativity is known to be useful for distinguishing acute promyelocytic leukemia (APL) from other subtypes of AML, but non-APL cases without HLA-DR antigen expression have been reported....
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Usefulness of PCR-SSP Method for Detection of HLA-DRB1*0405

Kim YH, Lee KH, Kwon OJ, Seok JH, Cho YS

  • KMID: 2116912
  • J Lab Med Qual Assur.
  • 2007 Jun;29(1):201-205.
BACKGROUND: The association between HLA-DRB1 gene and severity of rheumatoid arthritis (RA) has been documented in various reports. Especially, DRB1*0405 allele shows significant association with RA in Korean patients. DRB1*0405...
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Analysis of the markers related with relapse after withdrawal of antithyroid drug in patients with Graves' disease

Kim KW, Park YJ, Lee YJ, Lee EJ, Lee EK, Park MH, Park DJ, Cho BY

  • KMID: 2256414
  • Korean J Med.
  • 2007 May;72(5):522-528.
BACKGROUND: Graves' disease is an organ-specific autoimmune disease that is characterized by thyrotoxicosis, and this is caused by TSH receptor stimulating autoantibody. Antithyroid drugs have been a mainstay of treatment...
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The effects of peritoneal fluid from patients with advanced endometriosis on HLA-DR expression of monocytes

Na YJ, Park JH, Kwak JY, Lee KS

  • KMID: 2273000
  • Korean J Obstet Gynecol.
  • 2006 Dec;49(12):2589-2596.
OBJECTIVE: Endometriosis is a common gynecologic disorder characterized by the presence of endometrial tissue outside the uterine cavity. Many theories have been suggested to explain the mechanism for the development...
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Difference in HLA-DR Expression of Human Umbilical Cord Blood Derived Mesenchymal Stem Cells after Tri-lineage Differentiation

Baek GO, Sung JH, Moon JS, Ha CW

  • KMID: 1575229
  • J Korean Orthop Res Soc.
  • 2006 Oct;9(2):188-194.
PURPOSE: The aim of this study was to examine the expression of HLA-DR surface antigen in undifferentiated human umbilical cord blood (hUCB) derived mesenchymal stem cells (MSCs) and after osteogenic,...
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Role of Staphylococcal Superantigen in Atopic Dermatitis: Influence on Keratinocytes

Kim KH, Han JH, Chung JH, Cho KH, Eun HC

Staphylococcus aureus may perform an crucial function in atopic dermatitis (AD), via the secretion of superantigens, including staphylococcal enterotoxins (SE) A or B, and toxic shock syndrome toxin-1 (TSST-1). Dysregulated...
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