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Seroreversion and Acute Decompensation in Chronic Hepatitis B after Discontinuation of Oral Nucleotide Analog in the Patients Achieving HBsAg Loss

Cho HJ, Shin SK, Kwon OS, Kim JH, Kim YS

Although rare patients with chronic hepatitis B can achieve HBsAg loss on oral nucleos(t)ide analog (NA), the optimal timing of stopping oral NAs safely has been considered when HBsAg and...
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Result Patterns and Characteristics of HBeAg and HBV DNA in Patients with Chronic Hepatitis B

Choi EJ, Kim JH, Han MS

BACKGROUND: Discrepancies in the results between hepatitis B e-antigen (HBeAg) and hepatitis B virus (HBV) DNA levels pose difficulties in the management of chronic hepatitis B (CHB). This study aims...
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Analysis of Reentry Test for the Donors Showing Reactivity or Grey Zone in a HBV Surface Antigen Assay by a Chemiluminescent Immunoassay

Shin S, Kang J, Lee KR, Shin GS, Kang JW, Seo YI, Min H

BACKGROUND: If donors who were deferred due to the reactivity or grey zone in HBV surface antigen (HBsAg) assay want to donate blood again, they need to pass reentry tests....
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Development of a Rapid Automated Fluorescent Lateral Flow Immunoassay to Detect Hepatitis B Surface Antigen (HBsAg), Antibody to HBsAg, and Antibody to Hepatitis C

Ryu JH, Kwon M, Moon JD, Hwang MW, Lee JM, Park KH, Yun SJ, Bae HJ, Choi A, Lee H, Jung B, Jeong J, Han K, Kim Y, Oh EJ

BACKGROUND: Accurate, rapid, and cost-effective screening tests for hepatitis B virus (HBV) and hepatitis C virus (HCV) infection may be useful in laboratories that cannot afford automated chemiluminescent immunoassays (CLIAs)....
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New perspectives of biomarkers for the management of chronic hepatitis B

Lin CL, Kao JH

With recent advances in molecular and genomic investigations, the impact of hepatitis B viral and host factors on the progression of chronic HBV infection has been explored. For viral factors,...
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Results of Proficiency Tests for HBsAg and Anti-HCV as the Blood Donor Screening Testing (2012~2015)

Lee MN, Kim JN, Cha YJ, Park QE, Kim HO, Kwon GC, Choi YS, Kwon JR

BACKGROUND: Donor screening test is one of the most important processes for blood safety management. Korea Center for Disease Control and Prevention (KCDC) has been conducting an annual proficiency test...
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Prevalence of Hepatitis B Virus and HIV Co-infection in Korea

Lee HH, Hong HG, Son JS, Kwon SM, Lim BG, Lee KB, Kim GH

Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) have a common route like sexually transmitted infections (STIs), vertical transmission and blood transfusion, etc. Therefore, it was necessary to be...
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Increasing the Efficiency of Laboratory Performance by Using the Onboard Dilution Algorithm of the Elecsys Hepatitis B Surface Antigen II Quantitative Assay

Sohn JY, Oh EJ, Kim HS, Park HD, Kang ES

BACKGROUND: The Elecsys hepatitis B surface antigen (HBsAg) II quantitative assay is a newly introduced electrochemiluminescence immunoassay incorporating an initial 1:400 onboard dilution and a simple algorithm to determine HBsAg...
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Spontaneous HBsAg loss in Korean patients: relevance of viral genotypes, S gene mutations, and covalently closed circular DNA copy numbers

Kim KH, Chang HY, Park JY, Park ES, Park YK, Han KH, Ahn SH

BACKGROUND/AIMS: Occult HBV infection can persist following HBsAg loss and be transmitted, but the virological features are not well defined. METHODS: Here we investigated 25 Korean patients who lost HBsAg during...
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Occult hepatitis B virus infection: clearance or disguise?

Kim JW

No abstract available.
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Risk stratification of HBV infection in Asia-Pacific region

Kao JH

Hepatitis B virus (HBV) infection is the major etiology of chronic liver disease worldwide and thus a global health problem, especially in Asia-Pacific region. The long-term outcomes of Asian HBV...
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Inactive hepatitis B surface antigen carriers and intrafamilial tramsmission: results of a 10-year study

Demirturk , Demirdal T

BACKGROUND/AIMS: The aims of the present study were to determine the outcomes of inactive hepatitis B virus (HBV) surface antigen (HBsAg) carriers over a 10-year study period and to elucidate...
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HBsAg level and clinical course in patients with chronic hepatitis B treated with nucleoside analogue: five years of follow-up data

Kim JH, Choi YJ, Moon HW, Ko SY, Choe WH, Kwon SY

BACKGROUND/AIMS: Quantification of the hepatitis B surface antigen (HBsAg) is increasingly used to determine the treatment response in patients with chronic hepatitis B (CHB). However, there are limited data about...
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Performance Evaluation of 3 Kinds of HBsAg Qualitative Assays and 2 Kinds of Quantitative Assays

Park JS, Choi JI, Lim JH, Jung J, Lee SH, Park NH, Shin JW, Nah YW, Nam CW, Cha YJ, Kim SR

BACKGROUND: Currently used techniques for quantitation of HBsAg often yield discordant results; therefore, development of quantitation techniques that can detect HBsAg with high accuracy has become very important. Recent advances...
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Performance Evaluation of Immunoassay Detection of HBsAg Mutants and Their Clinical Significance in the High Risk Groups

Choi JI, Lim JH, Jeong J, Lee SH, Park JS, Park NH, Shin JW, Nah YW, Nam CW, Cha YJ, Kim SR

  • KMID: 2312217
  • Lab Med Online.
  • 2013 Apr;3(2):88-96.
BACKGROUND: False negative results have been reported in the immunodetection of hepatitis B virus (HBV) because of the existence of the various mutants of the virus, causing most suppliers to...
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Evaluation of the VITROS 3600 Analyzer for HBsAg

Jung YS, Lim YA

  • KMID: 1424264
  • Korean J Blood Transfus.
  • 2013 Apr;24(1):41-47.
BACKGROUND: The VITROS 3600 (Ortho Clinical Diagnostics, Johnson & Johnson, Buckinghamshire, UK), which uses the enhanced chemiluminescence immunoassay, has recently been introduced; however, it has not been evaluated for detection...
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Elecsys Hepatitis B Surface Antigen Quantitative Assay: Performance Evaluation and Correlation with Hepatitis B Virus DNA during 96 Weeks of Follow-up in Chronic Hepatitis B Patients

Lee HJ, Kim SY, Lee SM, Heo J, Kim HH, Chang CL, Lee EY, Son HC

  • KMID: 2434483
  • Ann Lab Med.
  • 2012 Nov;32(6):420-425.
BACKGROUND: Treatment for chronic hepatitis B aims to suppress virus replication and virus sequestration in hepatocytes. Covalently closed circular (ccc) DNA is the template for transcription of viral genes and...
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Pretreatment serum HBsAg-to-HBV DNA ratio predicts a virologic response to entecavir in chronic hepatitis B

Song JC, Min BY, Kim JW, Kim JY, Kim YM, Shin CM, Lee SH, Hwang JH, Jeong SH, Kim N, Lee DH

BACKGROUND/AIMS: Decay of hepatitis B surface antigen (HBsAg) titers has previously been shown to be predictive of a virologic response (VR), especially during peginterferon-alpha therapy. However, the role of HBsAg...
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True Hepatitis B Virus Surface Antigen Prevalence among Korean Blood Donors

Kim MJ, Park Q

  • KMID: 1442277
  • Korean J Blood Transfus.
  • 2011 Dec;22(3):189-197.
BACKGROUND: The sensitivity of the blood screening test is crucial to ensure blood safety. Generally the test methods with greater sensitivity tend to have lower specificity. Therefore, secondary confirmatory tests...
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Annual Report on External Quality Assessment in Immunoserology in Korea (2009)

Cha YJ, Kwon SY, Kim TY, Kim JR, Kim HS, Park MH, Park SH, Park AJ, Bai JH, Son HC, Lee KS, Chae SL

  • KMID: 2200548
  • J Lab Med Qual Assur.
  • 2010 Jun;32(1):45-68.
The followings are the results for external quality assessment (EQA) in immunoserology for 2009: Evaluation of EQA was done in 2 trials in April and November, about 99% of laboratories...
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