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Differentially-altered vascular guanylate cyclase isoforms in experimental hypertensive rats

Lee JU, Kang DG, Kook H, Kim IK, Oh BS

Pathophysiological implications of the vascular nitric oxide (NO)/cGMP pathway were investigated in various rat models of hypertension. The expression of brain and endothelial constitutive NO synthases (bNOS, ecNOS) was determined...
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The effects of oxygen radicals on the activity of nitric oxide synthase and guanylate cyclase

Kim SM, Byun JS, Jung YD, Kang IC, Choi SY, Lee KY

  • KMID: 755012
  • Exp Mol Med.
  • 1998 Dec;30(4):221-226.
Reactive oxygen species such as superoxides, hydrogen peroxide (H2O2) and hydroxyl radicals have been suggested to be involved in the catalytic action of nitric oxide synthase (NOS) to produce NO...
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