Skip Navigation
Skip to contents
Results by Year

View Wide

Filter

ARTICLE TYPE

more+
SELECT FILTER
 
Close

PUBLICATION DATE

0 results
Display

Intact Recognition Memory and Altered Hippocampal Glucocorticoid Receptor Signaling in Fkbp5-deficient Mice Following Acute Uncontrollable Stress

Jeon YJ, Choi BR, Park MS, Jang YS, Yoon S, Lyoo IK, Han JS

The FK506 binding protein 5 (FKBP5) is a co-chaperone that regulates the activity of the glucocorticoid receptor (GR) and has been reported to mediate stress resilience. This study aimed to...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Antidepressant effects of capsaicin in rats with chronic unpredictable mild stress-induced depression

Lim JO, Kim MJ, Bae JB, Jeon CH, Han JH, Sim TH, Kim YJ

Purpose: This study was conducted to assess the antidepressant effects of capsaicin in chronic depressive rats and elucidate the mechanism underlying its effects. Methods: Male Wistar rats (280~320 g, 8 weeks...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Regulation of Gut Microbiota Disrupts the Glucocorticoid Receptor Pathway and Inflammation-related Pathways in the Mouse Hippocampus

Rao X, Liu L, Wang H, Yu Y, Li W, Chai T, Zhou W, Ji P, Song J, Wei H, Xie P

An increasing number of studies have recently indicated the important effects of gut microbes on various functions of the central nervous system. However, the underlying mechanisms by which gut microbiota regulate...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Response of Glucocorticoid Receptor Alpha and Histone Deacetylase 2 to Glucocorticoid Treatment Predicts the Prognosis of Sudden Sensorineural Hearing Loss

Zhang X, Chen J, Gao Z, Qi H, Dai Y, She W

OBJECTIVES: To investigate glucocorticoid receptor (GR) and histone deacetylase 2 (HDAC2) gene expression and protein levels in peripheral blood mononuclear cells (PBMCs) of patients with severe or profound sudden sensorineural...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Anti-Human Rhinovirus 1B Activity of Dexamethasone viaGCR-Dependent Autophagy Activation

Lee JS, Kim SR, Song JH, Lee YP, Ko HJ

OBJECTIVES: Human rhinoviruses (HRVs) are the major cause of the common cold. Currently there is no registered, clinically effective, antiviral chemotherapeutic agent to treat diseases caused by HRVs. In this...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Bifidobacterium longum and Lactobacillus helveticus Synergistically Suppress Stress-related Visceral Hypersensitivity Through Hypothalamic-Pituitary-Adrenal Axis Modulation

Ait-Belgnaoui A, Payard I, Rolland C, Harkat C, Braniste V, Théodorou V, Tompkins T

  • KMID: 2417281
  • J Neurogastroenterol Motil.
  • 2018 Jan;24(1):138-146.
  • doi: 10.5056/jnm16167
BACKGROUND/AIMS: Visceral pain and hypothalamic-pituitary-adrenal axis (HPA) dysregulation is a common characteristic in irritable bowel syndrome (IBS) patients. Previously, we reported that a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Histone deacetylase inhibition attenuates hepatic steatosis in rats with experimental Cushing's syndrome

Kim M, Lee HA, Cho HM, Kang SH, Lee E, Kim IK

Cushing's syndrome (CS) is a collection of symptoms caused by prolonged exposure to excess cortisol. Chronically elevated glucocorticoid (GC) levels contribute to hepatic steatosis. We hypothesized that histone deacetylase inhibitors...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Effect of Saccharin Intake in Restraint-induced Stress Response Reduction in Rats

Park JM, Song MK, Kim YJ, Kim YJ

PURPOSE: Stress activates the sympathetic nervous system and hypothalamic-pituitary-adrenal (HPA) axis and induces the release of glucocorticoids. Saccharin is 300 times sweeter than sucrose, but does not increase blood insulin...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Selective Activator of the Glucocorticoid Receptor Compound A Dissociates Therapeutic and Atrophogenic Effects of Glucocorticoid Receptor Signaling in Skin

Klopot A, Baida G, Bhalla P, Haegeman G, Budunova I

BACKGROUND: Glucocorticoids are effective anti-inflammatory drugs widely used in dermatology and for the treatment of blood cancer patients. Unfortunately, chronic treatment with glucocorticoids results in serious metabolic and atrophogenic adverse...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
The prognostic value of glucocorticoid receptors for adult acute lymphoblastic leukemia

Bedewy AM, EL-Maghraby SM, Kandil NS, El-Bendary WR

BACKGROUND: Therapeutic protocols used in adult acute lymphoblastic leukemia (ALL) are widely variable, and glucocorticoids (GCs) are essential components in ALL treatment. Therefore, this study aimed to evaluate the distribution...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Mechanisms of Glucocorticoid Action in Chronic Rhinosinusitis

Lee SH

The innate immune system and its complex interplay with the adaptive immune system are increasingly being recognized as important factors in the pathogenesis of chronic rhinosinusitis (CRS). Adaptive immune components,...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Sequential alterations of glucocorticoid receptors in the hippocampus of STZ-treated type 1 diabetic rats

Shin JH, Seong JK, Yi SS

Type 1 diabetes is a common metabolic disorder accompanied by increased blood glucose levels along with glucocorticoid and cognitive deficits. The disease is also thought to be associated with environmental...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Direct Corticosteroid Modulation of GABAergic Neurons in the Anterior Hypothalamic Area of GAD65-eGFP Mice

Shin SY, Han TH, Lee SY, Han SK, Park JB, Erdelyi F, Szabo G, Ryu PD

Corticosterone is known to modulate GABAergic synaptic transmission in the hypothalamic paraventricular nucleus. However, the underlying receptor mechanisms are largely unknown. In the anterior hypothalamic area (AHA), the sympathoinhibitory center...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Polymorphisms of the NR3C1 gene in Korean children with nephrotic syndrome

Cho HY, Choi HJ, Lee SH, Lee HK, Kang HK, Ha IS, Choi Y, Cheong HI

PURPOSE: Idiopathic nephrotic syndrome (NS) can be clinically classified as steroid-sensitive and steroid-resistant. The detailed mechanism of glucocorticoid action in NS is currently unknown. METHODS: In this study, we investigated...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Effects of GR beta Overexpression on Steroid-induced Changes of the Whole Genes in the A549 Airway Epithelial Cells

  • KMID: 2234533
  • Korean J Asthma Allergy Clin Immunol.
  • 2008 Sep;28(3):220-225.
BACKGROUND: Glucocorticoid receptor beta (GR beta) may not bind to ligands and is thought to affect gene transcription only by acting as a dominant negative inhibitor of Glucocorticoid receptor alpha...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Role of Glucocorticoid Receptor on Insulin Secretion and Synthesis in INS-1 Cells

Yang JY, Kang MS, Song TH, Jeong IK, Seo PJ, Kim HJ

  • KMID: 2331791
  • J Korean Diabetes Assoc.
  • 2006 Nov;30(6):428-434.
BACKGROUND: Glucocorticoids play important roles in the regulation of glucose homeostasis. It is well known that glucocorticoids reduce hepatic and peripheral tissue sensitivity to insulin, but the roles of glucocorticoids...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Expression of glucocorticoid receptor mRNAs in glucocorticoid-resistant nasal polyps

Choi BR, Kwon JH, Gong SJ, Kwon MS, Cho JH, Kim JH, Oh S, Roh HJ, Kim DE

  • KMID: 1098080
  • Exp Mol Med.
  • 2006 Oct;38(5):466-473.
Glucocorticoids (GCs) are the most effective group of medications available to treat inflammation. Although most patients with inflammation respond to GC, a small group of patients exhibit persistent GC-resistance with...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Increased Expression of Glucocorticoid Receptor beta Messenger RNA in Patients with Ankylosing Spondylitis

Lee CK, Lee EY, Cho YS, Moon KA, Yoo B, Moon HB

BACKGROUND: Glucocorticoids have been known to be less effective for treating ankylosing spondylitis (AS) patients than for treating rheumatoid arthritis (RA) patients. To elucidate the mechanisms underlying this phenomenon, we...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Clinical Usefulness of Glucocorticoid Receptor beta Expression and NF-kappa B Activity in Patients with Ulcerative Colitis

Kim KJ, Myung SJ, Hong SS, Lee YJ, Lee SM, Byeon JS, Yang SK, Hong WS, Kim JH, Min YI

  • KMID: 2439744
  • Korean J Gastroenterol.
  • 2005 Feb;45(2):103-110.
BACKGROUND/AIMS: Glucocorticoid resistance poses a challenging clinical problem in inflammatory bowel disease because more than one fourth of patients with severe ulcerative colitis do not respond to anti-inflammatory steroids....
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Effect of GRbeta expression on steroid-induced transcriptional activity in airway epithelial cells

Jee YK, Kim YS, Park JS, Lee KY

  • KMID: 2178420
  • J Asthma Allergy Clin Immunol.
  • 2003 Dec;23(4):810-817.
BACKGROUND: It has been known that GRbeta(90 kDa), an alternative splicing variant, can not bind ligand and may act as a domiant negative inhibitor of GRalpha. But there is little...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close

Go to Top

Copyright © 2023 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr