- Intact Recognition Memory and Altered Hippocampal Glucocorticoid Receptor Signaling in Fkbp5-deficient Mice Following Acute Uncontrollable Stress
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Jeon YJ, Choi BR, Park MS, Jang YS, Yoon S, Lyoo IK, Han JS
- KMID: 2542309
- Exp Neurobiol.
- 2023 Apr;32(2):91-101.
- doi: 10.5607/en23006
The FK506 binding protein 5 (FKBP5) is a co-chaperone that regulates the activity of the glucocorticoid receptor (GR) and has been reported to mediate stress resilience. This study aimed to... -
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- Antidepressant effects of capsaicin in rats with chronic unpredictable mild stress-induced depression
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Lim JO, Kim MJ, Bae JB, Jeon CH, Han JH, Sim TH, Kim YJ
- KMID: 2548274
- J Korean Biol Nurs Sci.
- 2023 Feb;25(1):43-54.
- doi: 10.7586/jkbns.23.345
Purpose: This study was conducted to assess the antidepressant effects of capsaicin in chronic depressive rats and elucidate the mechanism underlying its effects. Methods: Male Wistar rats (280~320 g, 8 weeks... -
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- Regulation of Gut Microbiota Disrupts the Glucocorticoid Receptor Pathway and Inflammation-related Pathways in the Mouse Hippocampus
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Rao X, Liu L, Wang H, Yu Y, Li W, Chai T, Zhou W, Ji P, Song J, Wei H, Xie P
- KMID: 2513411
- Exp Neurobiol.
- 2021 Feb;30(1):59-72.
- doi: 10.5607/en20055
An increasing number of studies have recently indicated the important effects of gut microbes on various functions of the central nervous system. However, the underlying mechanisms by which gut microbiota regulate... -
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- Response of Glucocorticoid Receptor Alpha and Histone Deacetylase 2 to Glucocorticoid Treatment Predicts the Prognosis of Sudden Sensorineural Hearing Loss
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Zhang X, Chen J, Gao Z, Qi H, Dai Y, She W
- KMID: 2462732
- Clin Exp Otorhinolaryngol.
- 2019 Nov;12(4):367-375.
- doi: 10.21053/ceo.2018.01298
OBJECTIVES: To investigate glucocorticoid receptor (GR) and histone deacetylase 2 (HDAC2) gene expression and protein levels in peripheral blood mononuclear cells (PBMCs) of patients with severe or profound sudden sensorineural... -
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- Anti-Human Rhinovirus 1B Activity of Dexamethasone viaGCR-Dependent Autophagy Activation
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Lee JS, Kim SR, Song JH, Lee YP, Ko HJ
- KMID: 2431676
- Osong Public Health Res Perspect.
- 2018 Dec;9(6):334-339.
- doi: 10.24171/j.phrp.2018.9.6.07
OBJECTIVES: Human rhinoviruses (HRVs) are the major cause of the common cold. Currently there is no registered, clinically effective, antiviral chemotherapeutic agent to treat diseases caused by HRVs. In this... -
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- Bifidobacterium longum and Lactobacillus helveticus Synergistically Suppress Stress-related Visceral Hypersensitivity Through Hypothalamic-Pituitary-Adrenal Axis Modulation
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Ait-Belgnaoui A, Payard I, Rolland C, Harkat C, Braniste V, Théodorou V, Tompkins T
- KMID: 2417281
- J Neurogastroenterol Motil.
- 2018 Jan;24(1):138-146.
- doi: 10.5056/jnm16167
BACKGROUND/AIMS: Visceral pain and hypothalamic-pituitary-adrenal axis (HPA) dysregulation is a common characteristic in irritable bowel syndrome (IBS) patients. Previously, we reported that a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium... -
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- Histone deacetylase inhibition attenuates hepatic steatosis in rats with experimental Cushing's syndrome
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Kim M, Lee HA, Cho HM, Kang SH, Lee E, Kim IK
- KMID: 2398552
- Korean J Physiol Pharmacol.
- 2018 Jan;22(1):23-33.
- doi: 10.4196/kjpp.2018.22.1.23
Cushing's syndrome (CS) is a collection of symptoms caused by prolonged exposure to excess cortisol. Chronically elevated glucocorticoid (GC) levels contribute to hepatic steatosis. We hypothesized that histone deacetylase inhibitors... -
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- Effect of Saccharin Intake in Restraint-induced Stress Response Reduction in Rats
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Park JM, Song MK, Kim YJ, Kim YJ
- KMID: 2173178
- J Korean Biol Nurs Sci.
- 2016 Feb;18(1):36-42.
- doi: 10.7586/jkbns.2016.18.1.36
PURPOSE: Stress activates the sympathetic nervous system and hypothalamic-pituitary-adrenal (HPA) axis and induces the release of glucocorticoids. Saccharin is 300 times sweeter than sucrose, but does not increase blood insulin... -
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- Selective Activator of the Glucocorticoid Receptor Compound A Dissociates Therapeutic and Atrophogenic Effects of Glucocorticoid Receptor Signaling in Skin
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Klopot A, Baida G, Bhalla P, Haegeman G, Budunova I
- KMID: 2380877
- J Cancer Prev.
- 2015 Dec;20(4):250-259.
- doi: 10.15430/JCP.2015.20.4.250
BACKGROUND: Glucocorticoids are effective anti-inflammatory drugs widely used in dermatology and for the treatment of blood cancer patients. Unfortunately, chronic treatment with glucocorticoids results in serious metabolic and atrophogenic adverse... -
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- The prognostic value of glucocorticoid receptors for adult acute lymphoblastic leukemia
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Bedewy AM, EL-Maghraby SM, Kandil NS, El-Bendary WR
- KMID: 2133758
- Blood Res.
- 2015 Dec;50(4):235-241.
- doi: 10.5045/br.2015.50.4.235
BACKGROUND: Therapeutic protocols used in adult acute lymphoblastic leukemia (ALL) are widely variable, and glucocorticoids (GCs) are essential components in ALL treatment. Therefore, this study aimed to evaluate the distribution... -
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- Mechanisms of Glucocorticoid Action in Chronic Rhinosinusitis
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Lee SH
- KMID: 2130259
- Allergy Asthma Immunol Res.
- 2015 Nov;7(6):534-537.
- doi: 10.4168/aair.2015.7.6.534
The innate immune system and its complex interplay with the adaptive immune system are increasingly being recognized as important factors in the pathogenesis of chronic rhinosinusitis (CRS). Adaptive immune components,... -
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- Sequential alterations of glucocorticoid receptors in the hippocampus of STZ-treated type 1 diabetic rats
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Shin JH, Seong JK, Yi SS
- KMID: 1737606
- J Vet Sci.
- 2014 Mar;15(1):19-26.
- doi: 10.4142/jvs.2014.15.1.19
Type 1 diabetes is a common metabolic disorder accompanied by increased blood glucose levels along with glucocorticoid and cognitive deficits. The disease is also thought to be associated with environmental... -
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- Direct Corticosteroid Modulation of GABAergic Neurons in the Anterior Hypothalamic Area of GAD65-eGFP Mice
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Shin SY, Han TH, Lee SY, Han SK, Park JB, Erdelyi F, Szabo G, Ryu PD
- KMID: 1448920
- Korean J Physiol Pharmacol.
- 2011 Jun;15(3):163-169.
- doi: 10.4196/kjpp.2011.15.3.163
Corticosterone is known to modulate GABAergic synaptic transmission in the hypothalamic paraventricular nucleus. However, the underlying receptor mechanisms are largely unknown. In the anterior hypothalamic area (AHA), the sympathoinhibitory center... -
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- Polymorphisms of the NR3C1 gene in Korean children with nephrotic syndrome
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Cho HY, Choi HJ, Lee SH, Lee HK, Kang HK, Ha IS, Choi Y, Cheong HI
- KMID: 2281031
- Korean J Pediatr.
- 2009 Nov;52(11):1260-1266.
- doi: 10.3345/kjp.2009.52.11.1260
PURPOSE: Idiopathic nephrotic syndrome (NS) can be clinically classified as steroid-sensitive and steroid-resistant. The detailed mechanism of glucocorticoid action in NS is currently unknown. METHODS: In this study, we investigated... -
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- Effects of GR beta Overexpression on Steroid-induced Changes of the Whole Genes in the A549 Airway Epithelial Cells
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- KMID: 2234533
- Korean J Asthma Allergy Clin Immunol.
- 2008 Sep;28(3):220-225.
BACKGROUND: Glucocorticoid receptor beta (GR beta) may not bind to ligands and is thought to affect gene transcription only by acting as a dominant negative inhibitor of Glucocorticoid receptor alpha... -
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- Role of Glucocorticoid Receptor on Insulin Secretion and Synthesis in INS-1 Cells
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Yang JY, Kang MS, Song TH, Jeong IK, Seo PJ, Kim HJ
- KMID: 2331791
- J Korean Diabetes Assoc.
- 2006 Nov;30(6):428-434.
BACKGROUND: Glucocorticoids play important roles in the regulation of glucose homeostasis. It is well known that glucocorticoids reduce hepatic and peripheral tissue sensitivity to insulin, but the roles of glucocorticoids... -
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- Expression of glucocorticoid receptor mRNAs in glucocorticoid-resistant nasal polyps
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Choi BR, Kwon JH, Gong SJ, Kwon MS, Cho JH, Kim JH, Oh S, Roh HJ, Kim DE
- KMID: 1098080
- Exp Mol Med.
- 2006 Oct;38(5):466-473.
Glucocorticoids (GCs) are the most effective group of medications available to treat inflammation. Although most patients with inflammation respond to GC, a small group of patients exhibit persistent GC-resistance with... -
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- Increased Expression of Glucocorticoid Receptor beta Messenger RNA in Patients with Ankylosing Spondylitis
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Lee CK, Lee EY, Cho YS, Moon KA, Yoo B, Moon HB
- KMID: 1718037
- Korean J Intern Med.
- 2005 Jun;20(2):146-151.
- doi: 10.3904/kjim.2005.20.2.146
BACKGROUND: Glucocorticoids have been known to be less effective for treating ankylosing spondylitis (AS) patients than for treating rheumatoid arthritis (RA) patients. To elucidate the mechanisms underlying this phenomenon, we... -
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- Clinical Usefulness of Glucocorticoid Receptor beta Expression and NF-kappa B Activity in Patients with Ulcerative Colitis
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Kim KJ, Myung SJ, Hong SS, Lee YJ, Lee SM, Byeon JS, Yang SK, Hong WS, Kim JH, Min YI
- KMID: 2439744
- Korean J Gastroenterol.
- 2005 Feb;45(2):103-110.
BACKGROUND/AIMS: Glucocorticoid resistance poses a challenging clinical problem in inflammatory bowel disease because more than one fourth of patients with severe ulcerative colitis do not respond to anti-inflammatory steroids.... -
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- Effect of GRbeta expression on steroid-induced transcriptional activity in airway epithelial cells
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Jee YK, Kim YS, Park JS, Lee KY
- KMID: 2178420
- J Asthma Allergy Clin Immunol.
- 2003 Dec;23(4):810-817.
BACKGROUND: It has been known that GRbeta(90 kDa), an alternative splicing variant, can not bind ligand and may act as a domiant negative inhibitor of GRalpha. But there is little... -
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