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Long-Term Outcomes of Deep Brain Stimulation in Pantothenate Kinase-Associated Neurodegeneration-Related Dystonia

Woo KA, Kim HJ, Jeon SH, Park HR, Park KW, Lee SH, Chung SJ, Chae JH, Paek SH, Jeon B

Objective To investigate the long-term clinical outcomes of pallidal deep brain stimulation (GPi-DBS) in patients with pantothenate kinase-associated neurodegeneration (PKAN). Methods We reviewed the records of patients with genetically confirmed PKAN...
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Pallidus Stimulation for Chorea-Acanthocytosis: A Systematic Review and Meta-Analysis of Individual Data

He W, Li C, Dong H, Shao L, Yin B, Li D, Ye L, Hu P, Zhang C, Yi W

A significant proportion of patients with chorea-acanthocytosis (ChAc) fail to respond to standard therapies. Recent evidence suggests that globus pallidus internus (GPi) deep brain stimulation (DBS) is a promising treatment...
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Clinical Implications of Focal Mineral Deposition in the Globus Pallidus on CT and Quantitative Susceptibility Mapping of MRI

Kim H, Jang J, Kang J, Jang S, Nam Y, Choi Y, Shin Ny, Ahn KJ, Kim Bs

Objective: To assess focal mineral deposition in the globus pallidus (GP) by CT and quantitative susceptibility mapping (QSM) of MRI scans and evaluate its clinical significance, particularly cerebrovascular degeneration. Materials and...
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Dual Pallidal and Thalamic Deep Brain Stimulation for Complex Ipsilateral Dystonia

Chang KW, Kim MJ, Park SH, Chang WS, Jung HH, Chang JW

Purpose: Globus pallidus pars interna (GPi) has become an established target for deep brain stimulation (DBS) in dystonia. Previous studies suggest that targeting the ventralis oralis (Vo) complex nucleus improves...
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Successful Pallidal Stimulation in a Patient with KMT2B-Related Dystonia

Mun JK, Kim AR, Ahn JH, Kim M, Cho JW, Lee JI, Cho KR, Youn J

Although the KMT2B gene was identified as a causative gene for early-onset generalized dystonia, the efficacy of deep brain stimulation (DBS) in KMT2B-related dystonia has not been clearly elucidated. Here,...
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Enhanced Bidirectional Connectivity of the Subthalamo-pallidal Pathway in 6-OHDA-mouse Model of Parkinson's Disease Revealed by Probabilistic Tractography of Diffusion-weighted MRI at 9.4T

Kim AY, Oh C, Im HJ, Baek HM

An important challenge in Parkinson’s disease (PD) based neuroscience and neuroimaging is mapping the neuronal connectivity of the basal ganglia to understand how the disease affects brain circuitry. However, a...
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Rescue Levodopa/Carbidopa Intestinal Gel for Secondary Deep Brain Stimulation Failure

Bautista J, Oyama G, Nuermaimaiti M, Sekimoto S, Sasaki F, Hatano T, Nishioka K, Ito M, Umemura A, Ishibashi , Shimo Y, Hattori N

Objective The long-term efficacy of deep brain stimulation (DBS) for motor fluctuations in advanced Parkinson’s disease (PD) has been well established; however, motor fluctuations may recur over time despite multiple...
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High-Altitude Cerebral Edema Evaluated with MRI: A Case Report

Hwang S, Lee BH, Hwang YJ, Kim JW

High-altitude cerebral edema (HACE) is a rare life-threatening condition observed in individuals who climb high altitudes. This report describes the case of a 38-year-old man who recently climbed a 5000-m-high...
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Subcortical Volume Changes in Migraine with Aura

Petrusic I, Dakovic M, Zidverc-Trajkovic J

BACKGROUND AND PURPOSE: Various features of the cerebral cortex and white matter have been extensively investigated in migraine with aura (MwA), but the morphological characteristics of subcortical structures have been...
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Pivotal Role of Subcortical Structures as a Network Hub in Focal Epilepsy: Evidence from Graph Theoretical Analysis Based on Diffusion-Tensor Imaging

Park KM, Lee BI, Shin KJ, Ha SY, Park J, Kim SE, Kim SE

BACKGROUND AND PURPOSE: There is accumulating evidence that epilepsy is caused by network dysfunction. We evaluated the hub reorganization of subcortical structures in patients with focal epilepsy using graph theoretical...
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Holmes' Tremor with Shoulder Pain Treated by Deep Brain Stimulation of Unilateral Ventral Intermediate Thalamic Nucleus and Globus Pallidus Internus

Aydın S, Canaz H, Erdogan ET, Durmaz N, Topcular B

A 21-year-old male was admitted with severe right arm and hand tremors after a thalamic hemorrhage caused by a traffic accident. He was also suffering from agonizing pain in his...
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Comparison of Pallidal and Subthalamic Deep Brain Stimulation in Parkinson's Disease: Therapeutic and Adverse Effects

Ryu HS, Kim MS, You S, Kim MJ, Kim YJ, Kim J, Kim K, Chung SJ

OBJECTIVE: To compare the therapeutic and adverse effects of globus pallidus interna (GPi) and subthalamic nucleus (STN) deep brain stimulation (DBS) for the treatment of advanced Parkinson's disease (PD). METHODS: We...
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Pregnancy and Delivery in a Generalized Dystonia Patient Treated with Internal Globus Pallidal Deep Brain Stimulation: a Case Report

Park HR, Lee JM, Park H, Shin CW, Kim HJ, Park HP, Kim DG, Jeon BS, Paek SH

Internal globus pallidus (GPi) deep brain stimulation (DBS) has been widely accepted as an effective treatment modality of medically refractory dystonia. However, there have been few studies regarding the safety...
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Globus Pallidus Interna Deep Brain Stimulation for Chorea-Acanthocytosis

Lee JH, Cho WH, Cha SH, Kang DW

Chorea-acanthocytosis (ChAc) is a rare hereditary disorder characterized by involuntary choreiform movements and erythrocytic acanthocytosis. Pharmacotherapy for control of involuntary movements has generally been of limited benefit. Deep brain stimulation...
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Neuronal Responses in the Globus Pallidus during Subthalamic Nucleus Electrical Stimulation in Normal and Parkinson's Disease Model Rats

Ryu SB, Bae EK, Kim J, Hwang YS, Im C, Chang JW, Shin HC, Kim KH

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been widely used as a treatment for the movement disturbances caused by Parkinson's disease (PD). Despite successful application of DBS,...
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Exofocal Anterograde Transsynaptic Neuronal Death in the Globus Pallidus: Two Case Reports

Koo MW, Kim YK, Ku KM, Park WW, Minn YK

BACKGROUND: Exofocal neuronal death in the substantia nigra (SN) is a well-known form of anterograde transsynaptic cell death. Exofocal neuronal death could theoretically also occur in the globus pallidus (GP)...
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Deep Brain Stimulation of the Globus Pallidus in a 7-Year-Old Girl with DYT1 Generalized Dystonia

Jin ST, Lee MK, Ghang JY, Jeon SM

  • KMID: 2339949
  • J Korean Neurosurg Soc.
  • 2012 Sep;52(3):261-263.
The experience of pediatric deep brain stimulation (DBS) of the globus pallidus internus (GPi) in the treatment of early-onset DYT1 generalized dystonia is still limited. Here, we report the surgical...
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Significance of Brain Magnetic Resonance Imaging in Severe Hyperbilirubinemia

You SY, Jwa HJ, Chang MY

  • KMID: 2280839
  • Korean J Perinatol.
  • 2011 Dec;22(4):310-318.
PURPOSE: We evaluated the brain magnetic resonance imaging (MRI) findings and significance in newborns with severe hyperbilirubinemia. METHODS: This study included 60 newborns with severe hyperbilirubinemia at the neonatal intensive care...
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Cognitive Dysfunction Following High Mountain Climbing

Lee H, Ryu SY, Yi HA

  • KMID: 2065768
  • J Korean Neurol Assoc.
  • 2011 Feb;29(1):40-44.
Few studies have investigated cognitive impairment associated with globus pallidal lesion after acute mountain sickness (AMS). A 54-year-old mountaineer presented with a slowed response, social withdrawal, and apathy after exposure...
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Outcome of Pallidal Deep Brain Stimulation in Meige Syndrome

Ghang JY, Lee MK, Jun SM, Ghang CG

OBJECTIVE: Meige syndrome is the combination of blepharospasm and oromandibular dystonia. We assessed the surgical results of bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) in patients with medically...
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