- A Multi-institutional Study of Prevalence and Clinicopathologic Features of Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) in Korea
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Seo JY, Park JH, Pyo JY, Cha YJ, Jung CK, Song DE, Kwak JJ, Park SY, Na HY, Kim JH, Seok JY, Kim HS, Hong SW
- KMID: 2465437
- J Pathol Transl Med.
- 2019 Nov;53(6):378-385.
- doi: 10.4132/jptm.2019.09.18
BACKGROUND: In the present multi-institutional study, the prevalence and clinicopathologic characteristics of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) were evaluated among Korean patients who underwent thyroidectomy for... -
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- Use of a High-Throughput Genotyping Platform (OncoMap) for RAS Mutational Analysis to Predict Cetuximab Efficacy in Patients with Metastatic Colorectal Cancer
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Kim D, Hong YS, Kim JE, Kim KP, Lee JL, Chun SM, Kim J, Jang SJ, Kim TW
- KMID: 2367501
- Cancer Res Treat.
- 2017 Jan;49(1):37-43.
- doi: 10.4143/crt.2016.069
PURPOSE: Cetuximab demonstrates improved efficacy outcomes in patients with metastatic colorectal cancer (mCRC) harboring wild-type KRAS exon 2. Resistance to cetuximab is mediated by activating less frequent mutations in the... -
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- Molecular Diagnosis for Cytologically Indeterminate Thyroid Nodules
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Hwang TS
- KMID: 2171223
- Int J Thyroidol.
- 2015 Nov;8(2):153-160.
- doi: 10.11106/ijt.2015.8.2.153
An accurate diagnosis of cancer or benign disease is important for the effective clinical management of the patients. Thyroid fine needle aspiration cytology (FNAC) is a safe and cost effective... -
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- MRAS Genetic Variation Is Associated with Atherothrombotic Stroke in the Han Chinese Population
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Liu H, Huang XQ, Yang M, Ji XM, Du X, Zheng J
- KMID: 1980541
- J Clin Neurol.
- 2013 Oct;9(4):223-230.
- doi: 10.3988/jcn.2013.9.4.223
BACKGROUND AND PURPOSE: Atherothrombotic cerebral infarction [atherothrombotic stroke (ATS)] shares common risk factors and pathophysiological mechanisms with coronary artery disease (CAD), and both diseases appear to have common susceptibility loci.... -
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- Correlations of Dynamic Contrast-Enhanced Magnetic Resonance Imaging with Morphologic, Angiogenic, and Molecular Prognostic Factors in Rectal Cancer
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Hong HS, Kim SH, Park HJ, Park MS, Kim KW, Kim WH, Kim NK, Lee JM, Cho HJ
- KMID: 1776927
- Yonsei Med J.
- 2013 Jan;54(1):123-130.
- doi: 10.3349/ymj.2013.54.1.123
PURPOSE: To investigate the correlations between parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and prognostic factors in rectal cancer. MATERIALS AND METHODS: We studied 29 patients with rectal cancer who... -
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- Gene Alterations of Ovarian Cancer Cells Expressing Estrogen Receptors by Estrogen and Bisphenol A Using Microarray Analysis
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Hwang KA, Park SH, Yi BR, Choi KC
- KMID: 2053658
- Lab Anim Res.
- 2011 Jun;27(2):99-107.
- doi: 10.5625/lar.2011.27.2.99
Since endocrine disrupting chemicals (EDCs) may interfere with the endocrine system(s) of our body and have an estrogenicity, we evaluated the effect(s) of bisphenol A (BPA) on the transcriptional levels... -
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- Mutation of the N-ras Gene in a Patient Suffering from the Blast Phase of Chronic Myelogenous Leukemia
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Song SH, Roh YW, Ahn YW, Kim YJ, Byoun YS, Choi JY, Hwang DW, Park BB, Choi JH, Kim IS, Kim BK, Lee YY
- KMID: 2252154
- Korean J Hematol.
- 2009 Jun;44(2):100-103.
- doi: 10.5045/kjh.2009.44.2.100
The blast phase in chronic myelogenous leukemia (CML) is associated with mutation of several genes. It is well known that p53 gene mutation plays a key role in the myeloid... -
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- The Difference in Biological Properties between Parental and v-Ha-ras Transformed NIH3T3 Cells
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Lee M, Ahn JH, Eum KH
- KMID: 2165985
- Cancer Res Treat.
- 2009 Jun;41(2):93-99.
PURPOSE: We performed experiments to investigate the change in cellular signaling that occurs during the transformation of a normal cell to a cell capable of cancerous growth, and we did... -
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- ras Mutation in Korean Papillary Thyroid Carcinomas
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Jung JH, Kim KS, Jung TS, Oh YL, Jang HW, Jung HS, Min YK, Lee MS, Lee MK, Kim KW, Chung JH
- KMID: 1512032
- J Korean Endocr Soc.
- 2007 Jun;22(3):203-209.
- doi: 10.3803/jkes.2007.22.3.203
BACKGROUND: RET/PTC rearrangement and mutations of BRAF and ras are well-known oncogenes involved in the pathogenesis of papillary thyroid carcinoma (PTC). The prevalence of RET/PTC rearrangement and BRAF mutations were... -
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- Expression of the RERG Gene is Gender-Dependent in Hepatocellular Carcinoma and Regulated by Histone Deacetyltransferases
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Wang AG, Fang W, Han YH, Cho SM, Choi JY, Lee KH, Kim WH, Kim JM, Park MG, Yu DY, Kim NS, Lee DS
- KMID: 1781911
- J Korean Med Sci.
- 2006 Oct;21(5):891-896.
- doi: 10.3346/jkms.2006.21.5.891
Ras-related, estrogen-regulated, and growth-inhibitory gene (RERG) is a novel gene that was first reported in breast cancer. However, the functions of RERG are largely unknown in other tumor types. In... -
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- EGFR Tyrosine Kinase Inhibitors for NSCLC
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Kim YC
- KMID: 1881512
- J Lung Cancer.
- 2005 Dec;4(2):71-73.
The EGFR Tyrosine kinase inhibitors (TKIs) show significant clinical benefit in selected population with no smoking history, adenocarcinoma or mutations in EGFR gene. Mutations of K-ras gene are associated with... -
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- Prognostic Factors in Children with Henoch-Schonlein Purpura Nephritis
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Choi HJ, Cho HY, Kim EJ, Lee BS, Kang HG, Ha IS, Cheong HI, Choi Y
- KMID: 1627743
- J Korean Soc Pediatr Nephrol.
- 2005 Oct;9(2):183-192.
PURPOSE: The long term disease course and prognostic factors were evaluated in childhood Henoch-Schonlein purpura nephritis(HSPN). METHODS: A total of 75 children(44 boys and 31 girls) with HSPN were included... -
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- Microarray Applications in Cancer Research
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Kim IJ, Kang HC, Park JG
- KMID: 2166133
- Cancer Res Treat.
- 2004 Aug;36(4):207-213.
DNA microarray technology permits simultaneous analysis of thousands of DNA sequences for genomic research and diagnostics applications. Microarray technology represents the most recent and exciting advance in the application of... -
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- Impact and Prevalence of Renin-angiotensin System Gene Polymorphism of Renal Anomalies in Turner Syndrome
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Park JK, Chung YH, Lee JN, Chung WY
- KMID: 2197714
- J Korean Soc Pediatr Nephrol.
- 2003 Apr;7(1):52-59.
PURPOSE: The renin-angiotensin system(RAS) plays an important role in renal growth and development. We have studied the prevalence of renal anomalies and documented the association between karyotype and renal anomalies... -
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- Chromosomal gains and losses in primary ovarian carcinomas by comparative genomic hybridization
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Cho SH, Kim MH, Lee NW, Kim YT, Lee KW
- KMID: 2020113
- Korean J Obstet Gynecol.
- 2003 Jan;46(1):38-43.
OBJECTIVE: Comparative genomic hybridization was performed to evaluate DNA sequence copy number changes in human ovarian carcinomas from paraffin-embedded tissue blocks. PATIENTS AND METHODS: DNA from 20 cases of primary ovarian... -
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- K-ras Gene Mutation in Non-Small Cell Lung Cancer
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Yoon HJ, Ju JY, Cho GJ, Kim EJ, Park KH, Kim KS, Ko YC, Lim SC, Kim YC, Park KO, Park JT
- KMID: 2200234
- J Lung Cancer.
- 2002 Dec;1(1):55-59.
PURPOSE: Point mutation of the K-ras gene causes irreversible binding of GTP to the P21-ras protein, which induces nuclear transcription factors and enhances cellular proliferation. Point mutation of the K-ras... -
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- Ras Gene Mutations and Expression of ERK1 and ERK2 Proteins in Stomach Cancer
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Yoo J, Kang SJ, Kim BK, Kang CS
- KMID: 2073724
- Korean J Pathol.
- 2002 Apr;36(2):77-83.
BACKGROUND: We investigated stomach cancers for ras abnormalities and expression of ERK1 and ERK2 to determine their significance in the tumor development and/or progression and to evaluate their potential... -
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- Correlation Of Metastasis And Prognostic Factors In Squamous Cell Carcinoma Of Head And Neck
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Seo GJ, Ryu SY, Kim OJ, Choi HR
- KMID: 1961168
- J Korean Assoc Oral Maxillofac Surg.
- 2002 Feb;28(1):7-15.
The present study was carried out to evaluate the correlation of metastasis and prognostic factors in squamous cell carcinoma of head and neck. Examination was performed on a series of... -
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- Mutation of Ha-ras Oncogene in Rat Salivary Gland Tumors Induced by DMBA
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Yeh BI, Han DP, Sohn JH, Yoon JH, Lee HA, Chang SJ, Kong ID, Kim HW, Choi JW
- KMID: 2166224
- Cancer Res Treat.
- 2001 Dec;33(6):495-499.
PURPOSE: The incidence of salivary gland tumor is approximately 2% among all head and neck tumors, of which malignant cases account for only about 5%. Much research has been performed... -
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- c-Jun N-terminal kinase is involved in motility of endothelial cell
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Shin EY, Kim SY, Kim EG
- KMID: 1457542
- Exp Mol Med.
- 2001 Dec;33(4):276-283.
Cell motility is essential for a wide range of cellular activities including anigogenesis as well as metastasis of tumor cells. Ras has been implicated in cell migration and invasion, and... -
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