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A Multi-institutional Study of Prevalence and Clinicopathologic Features of Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) in Korea

Seo JY, Park JH, Pyo JY, Cha YJ, Jung CK, Song DE, Kwak JJ, Park SY, Na HY, Kim JH, Seok JY, Kim HS, Hong SW

BACKGROUND: In the present multi-institutional study, the prevalence and clinicopathologic characteristics of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) were evaluated among Korean patients who underwent thyroidectomy for...
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Use of a High-Throughput Genotyping Platform (OncoMap) for RAS Mutational Analysis to Predict Cetuximab Efficacy in Patients with Metastatic Colorectal Cancer

Kim D, Hong YS, Kim JE, Kim KP, Lee JL, Chun SM, Kim J, Jang SJ, Kim TW

PURPOSE: Cetuximab demonstrates improved efficacy outcomes in patients with metastatic colorectal cancer (mCRC) harboring wild-type KRAS exon 2. Resistance to cetuximab is mediated by activating less frequent mutations in the...
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Molecular Diagnosis for Cytologically Indeterminate Thyroid Nodules

Hwang TS

An accurate diagnosis of cancer or benign disease is important for the effective clinical management of the patients. Thyroid fine needle aspiration cytology (FNAC) is a safe and cost effective...
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MRAS Genetic Variation Is Associated with Atherothrombotic Stroke in the Han Chinese Population

Liu H, Huang XQ, Yang M, Ji XM, Du X, Zheng J

BACKGROUND AND PURPOSE: Atherothrombotic cerebral infarction [atherothrombotic stroke (ATS)] shares common risk factors and pathophysiological mechanisms with coronary artery disease (CAD), and both diseases appear to have common susceptibility loci....
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Correlations of Dynamic Contrast-Enhanced Magnetic Resonance Imaging with Morphologic, Angiogenic, and Molecular Prognostic Factors in Rectal Cancer

Hong HS, Kim SH, Park HJ, Park MS, Kim KW, Kim WH, Kim NK, Lee JM, Cho HJ

PURPOSE: To investigate the correlations between parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and prognostic factors in rectal cancer. MATERIALS AND METHODS: We studied 29 patients with rectal cancer who...
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Gene Alterations of Ovarian Cancer Cells Expressing Estrogen Receptors by Estrogen and Bisphenol A Using Microarray Analysis

Hwang KA, Park SH, Yi BR, Choi KC

Since endocrine disrupting chemicals (EDCs) may interfere with the endocrine system(s) of our body and have an estrogenicity, we evaluated the effect(s) of bisphenol A (BPA) on the transcriptional levels...
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Mutation of the N-ras Gene in a Patient Suffering from the Blast Phase of Chronic Myelogenous Leukemia

Song SH, Roh YW, Ahn YW, Kim YJ, Byoun YS, Choi JY, Hwang DW, Park BB, Choi JH, Kim IS, Kim BK, Lee YY

The blast phase in chronic myelogenous leukemia (CML) is associated with mutation of several genes. It is well known that p53 gene mutation plays a key role in the myeloid...
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The Difference in Biological Properties between Parental and v-Ha-ras Transformed NIH3T3 Cells

Lee M, Ahn JH, Eum KH

  • KMID: 2165985
  • Cancer Res Treat.
  • 2009 Jun;41(2):93-99.
PURPOSE: We performed experiments to investigate the change in cellular signaling that occurs during the transformation of a normal cell to a cell capable of cancerous growth, and we did...
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ras Mutation in Korean Papillary Thyroid Carcinomas

Jung JH, Kim KS, Jung TS, Oh YL, Jang HW, Jung HS, Min YK, Lee MS, Lee MK, Kim KW, Chung JH

BACKGROUND: RET/PTC rearrangement and mutations of BRAF and ras are well-known oncogenes involved in the pathogenesis of papillary thyroid carcinoma (PTC). The prevalence of RET/PTC rearrangement and BRAF mutations were...
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Expression of the RERG Gene is Gender-Dependent in Hepatocellular Carcinoma and Regulated by Histone Deacetyltransferases

Wang AG, Fang W, Han YH, Cho SM, Choi JY, Lee KH, Kim WH, Kim JM, Park MG, Yu DY, Kim NS, Lee DS

Ras-related, estrogen-regulated, and growth-inhibitory gene (RERG) is a novel gene that was first reported in breast cancer. However, the functions of RERG are largely unknown in other tumor types. In...
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EGFR Tyrosine Kinase Inhibitors for NSCLC

Kim YC

  • KMID: 1881512
  • J Lung Cancer.
  • 2005 Dec;4(2):71-73.
The EGFR Tyrosine kinase inhibitors (TKIs) show significant clinical benefit in selected population with no smoking history, adenocarcinoma or mutations in EGFR gene. Mutations of K-ras gene are associated with...
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Prognostic Factors in Children with Henoch-Schonlein Purpura Nephritis

Choi HJ, Cho HY, Kim EJ, Lee BS, Kang HG, Ha IS, Cheong HI, Choi Y

  • KMID: 1627743
  • J Korean Soc Pediatr Nephrol.
  • 2005 Oct;9(2):183-192.
PURPOSE: The long term disease course and prognostic factors were evaluated in childhood Henoch-Schonlein purpura nephritis(HSPN). METHODS: A total of 75 children(44 boys and 31 girls) with HSPN were included...
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Microarray Applications in Cancer Research

Kim IJ, Kang HC, Park JG

  • KMID: 2166133
  • Cancer Res Treat.
  • 2004 Aug;36(4):207-213.
DNA microarray technology permits simultaneous analysis of thousands of DNA sequences for genomic research and diagnostics applications. Microarray technology represents the most recent and exciting advance in the application of...
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Impact and Prevalence of Renin-angiotensin System Gene Polymorphism of Renal Anomalies in Turner Syndrome

Park JK, Chung YH, Lee JN, Chung WY

  • KMID: 2197714
  • J Korean Soc Pediatr Nephrol.
  • 2003 Apr;7(1):52-59.
PURPOSE: The renin-angiotensin system(RAS) plays an important role in renal growth and development. We have studied the prevalence of renal anomalies and documented the association between karyotype and renal anomalies...
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Chromosomal gains and losses in primary ovarian carcinomas by comparative genomic hybridization

Cho SH, Kim MH, Lee NW, Kim YT, Lee KW

  • KMID: 2020113
  • Korean J Obstet Gynecol.
  • 2003 Jan;46(1):38-43.
OBJECTIVE: Comparative genomic hybridization was performed to evaluate DNA sequence copy number changes in human ovarian carcinomas from paraffin-embedded tissue blocks. PATIENTS AND METHODS: DNA from 20 cases of primary ovarian...
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K-ras Gene Mutation in Non-Small Cell Lung Cancer

Yoon HJ, Ju JY, Cho GJ, Kim EJ, Park KH, Kim KS, Ko YC, Lim SC, Kim YC, Park KO, Park JT

  • KMID: 2200234
  • J Lung Cancer.
  • 2002 Dec;1(1):55-59.
PURPOSE: Point mutation of the K-ras gene causes irreversible binding of GTP to the P21-ras protein, which induces nuclear transcription factors and enhances cellular proliferation. Point mutation of the K-ras...
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Ras Gene Mutations and Expression of ERK1 and ERK2 Proteins in Stomach Cancer

Yoo J, Kang SJ, Kim BK, Kang CS

  • KMID: 2073724
  • Korean J Pathol.
  • 2002 Apr;36(2):77-83.
BACKGROUND: We investigated stomach cancers for ras abnormalities and expression of ERK1 and ERK2 to determine their significance in the tumor development and/or progression and to evaluate their potential...
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Correlation Of Metastasis And Prognostic Factors In Squamous Cell Carcinoma Of Head And Neck

Seo GJ, Ryu SY, Kim OJ, Choi HR

  • KMID: 1961168
  • J Korean Assoc Oral Maxillofac Surg.
  • 2002 Feb;28(1):7-15.
The present study was carried out to evaluate the correlation of metastasis and prognostic factors in squamous cell carcinoma of head and neck. Examination was performed on a series of...
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Mutation of Ha-ras Oncogene in Rat Salivary Gland Tumors Induced by DMBA

Yeh BI, Han DP, Sohn JH, Yoon JH, Lee HA, Chang SJ, Kong ID, Kim HW, Choi JW

  • KMID: 2166224
  • Cancer Res Treat.
  • 2001 Dec;33(6):495-499.
PURPOSE: The incidence of salivary gland tumor is approximately 2% among all head and neck tumors, of which malignant cases account for only about 5%. Much research has been performed...
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c-Jun N-terminal kinase is involved in motility of endothelial cell

Shin EY, Kim SY, Kim EG

  • KMID: 1457542
  • Exp Mol Med.
  • 2001 Dec;33(4):276-283.
Cell motility is essential for a wide range of cellular activities including anigogenesis as well as metastasis of tumor cells. Ras has been implicated in cell migration and invasion, and...
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