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ras Gene Mutations in Malignant Fibrous Histiocytoma

Yoo J, Lee AW, Kang SJ, Kim BK

  • KMID: 2275609
  • Korean J Pathol.
  • 2001 Jun;35(3):232-237.
BACKGROUND: ras gene mutations have been described in various human malignancies, suggesting that their activation may play a role in oncogenesis. However, there are few reports concerning ras gene alterations...
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Patterns of p53 and H-ras Mutations related to Invasiveness and Differentiation of Transitional Cell Carcinoma in Human bladder

Woo SH, Lee HL, Kim WJ

  • KMID: 2290366
  • Korean J Urol.
  • 1999 Aug;40(8):963-970.
PURPOSE: To characterize the patterns of p53 & H-ras mutations related to invasiveness and differentiation of transitional cell carcinoma in human bladder. MATERIALS AND METHODS: Tissues from 52 patients diagnosed...
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Mutation of the N-ras Gene in a Patient Suffering from the Blast Phase of Chronic Myelogenous Leukemia

Song SH, Roh YW, Ahn YW, Kim YJ, Byoun YS, Choi JY, Hwang DW, Park BB, Choi JH, Kim IS, Kim BK, Lee YY

The blast phase in chronic myelogenous leukemia (CML) is associated with mutation of several genes. It is well known that p53 gene mutation plays a key role in the myeloid...
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Mutation of ras oncogene in pancreatic tumor

Song SY, Kim WH, Chung JB, Kang JK, Park IS, Choi HJ, Park YN, Chun MY

  • KMID: 1685448
  • Korean J Gastroenterol.
  • 1992 Aug;24(4):853-860.
No abstract available.
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Telomerase Activity and K-ras Gene Mutation in Pancreatic Juice for Diagnosis of Pancreatic Cancer

Jung HK, Son HY, Lee HC, Kim DY, Yi SY, Moon IH, Myung SJ, Seo DW, Lee SK, Min YI, Kim MH

  • KMID: 2038341
  • Korean J Gastroenterol.
  • 1999 Aug;34(2):245-254.
BACKGROUND/AIMS: The reactivation of telomerase may be concomitant with the cell immortality and mutations of the K-ras gene are common genetic alteration found in pancreatic carcinomas. The purpose of this...
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The relationship of the activation of ras oncogene to hepatitis Bviruss gene expression in human hepatocellular carcinoma

Han CJ, Lee HS, Kim CY

  • KMID: 1685412
  • Korean J Gastroenterol.
  • 1992 Jun;24(3):547-553.
No abstract available.
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Ras Gene Mutations and Expression of ERK1 and ERK2 Proteins in Stomach Cancer

Yoo J, Kang SJ, Kim BK, Kang CS

  • KMID: 2073724
  • Korean J Pathol.
  • 2002 Apr;36(2):77-83.
BACKGROUND: We investigated stomach cancers for ras abnormalities and expression of ERK1 and ERK2 to determine their significance in the tumor development and/or progression and to evaluate their potential...
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Activation Of H-Ras Oncogene In Rat Salivary Gland Tumors Induced By Dmba And Irradiation

Hu KS, Choi JW, Choi SC, Park TW, You DS

  • KMID: 1537338
  • J Korean Acad Oral Maxillofac Radiol.
  • 1998 Feb;28(1):245-259.
Cellular transforming genes have been identified in a number of different tumor cell lines and tumor types. A significant number of these oncogenes belong to the ras gene family. The...
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Expression of Ras Oncogene in the Intracpithelial Neoplasia and Carcinoma of the Uterine Cervix

Park SS, Choi KY, Nam KH, Lee KH

  • KMID: 1675691
  • Korean J Gynecol Oncol Colposc.
  • 1996 Sep;7(3):217-225.
Cellular oncogenes are expressed as an intrinsic part of the transformed or neoplastic phenotype. More than 60 of the known cellular oncogenes play a specific role in normal cellular development...
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Detection of ras gene mutations in human cancer by PCR-SSCP

Kim CM, Park JI, Kang CD, Kim SH, Park YH, Jung SJ, Jung BS

  • KMID: 1694335
  • J Korean Cancer Assoc.
  • 1993 Jun;25(3):429-444.
No abstract available.
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A study about the involvement of H-ras oncogene in acromegalic patients

Lim SK, Kwon YH, Chung YS, Ahn KJ, Lee EJ, Kim KR, Lee HC, Huh KB, Kim TS

  • KMID: 1698312
  • Korean J Med.
  • 1993 Sep;45(3):353-360.
No abstract available.
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Point mutation of K-ras oncogenes by paired polymerase chain reaction and gel electrophoresis in human colorectal cancers

Park WC, Jeon HM, Chang SK, Choo SY

  • KMID: 1693618
  • J Korean Surg Soc.
  • 1993 Jan;44(1):1-10.
No abstract available.
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Significance of K-ras mutation, K-ras expression and p53 expression in pancreatic cancer

Kim YC, Choi KH, Kim HG, Lee ES, Son GS

  • KMID: 2244393
  • Korean J Hepatobiliary Pancreat Surg.
  • 2000 Feb;4(1):111-121.
BACKGROUND: Though K-ras mutation and aberrant p53 have been considered the event of the oncogenesis of pancreatic adenocarcinoma, it is controversial that these have been attributed to difference of survival...
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Significance of K-ras Mutation and p53 Protein Expression in Pancreatic Adenocarcinoma

Kim YC, Choi KH

  • KMID: 2145297
  • J Korean Surg Soc.
  • 2000 Feb;58(2):271-279.
BACKGROUND: Activation of the K-ras oncogene by specific point mutations at codon 12 occurs at a remarkably high frequency in pancreatic adenocarcinomas. Also, inactivation of the p53 suppressor gene function...
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Extracellular Matrix, TGF - beta Gene and Ha-ras Oncogene Expression in Type I Neurofibromatosis

Jung JB, Kwon HJ, Rhu YW, Lee KS, Song JY

  • KMID: 2230634
  • Korean J Dermatol.
  • 1997 Apr;35(2):249-257.
BACKGROUND: Neurofibroma, the hallmark of neurofibromatosis, is a cutaneous or subcutaneous lesion, with a variable clinical presentation. Histologically, neurofibroma consists of proliferation of nerve derived cellular elements, together with an...
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K-ras Gene Mutations and Expression of K-ras, p16, Cyclin D1 and p53 in Synchronous Lesions of The Colon Adenoma-Carcinoma Sequences

Oh HE, Cho SJ, Won NH, Lee D, Kim I, Yeom BW

  • KMID: 1725816
  • Korean J Pathol.
  • 2001 Aug;35(4):291-298.
BACKGROUND: The colorectal adenoma-carcinoma sequence represents a well-known para-digm for the sequential development of cancer driven by the accumulation of genomic defects. Although the colorectal adenoma-carcinoma sequence has been well...
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Expression of ras oncogene in cervical carcinoma and its relevance to prognosis

Lee HP, Kim WJ, Kim JH, Song YS, Kang SB

  • KMID: 1687481
  • Korean J Gynecol Oncol Colposc.
  • 1993 Mar;4(1):32-42.
We studied 42 with normal eervix and 63 wornen with invasive cervical carcinoma to investigate the correlation between the prognostie variables of the cervical cancer(age, clinical stage, tumor size, depth...
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Prevalence of Gsa, ras, p53 Mutations and ret/PTC Rearrangement in Differentiated Thyroid Tumors of Korean Population

Ahn IM, Kim YI, Park HS, Park KY, Hong SJ, Lee EJ, Gong KY

  • KMID: 2142205
  • J Korean Soc Endocrinol.
  • 1998 Jun;13(2):189-197.
BACKGROUND: In thyroid tumor, ras, Gsa, p53 mutation and ret/FfC rearrangement have been reported with variable prevalences in different geographic regions. We studied the prevalences of these mutations and reammgement...
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Identification of mutagenic site of c-H-ras oncogene damaged by N-acetoxyacetylaminofluorene(AAAF)

Oh SH, Kim KH, Lee SE, Yeh BI

A molecularly cloned human cellular H-ras (c-H-ras) oncogene(pbc N1 plasmid) was treated with N-acetoxyacetylaminofluorene (AAAF) in vitro and subcloned into E.coli. This was done to identify the mutational changes at...
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Analysis of mutations of ras and p53 gene in multiple myeloma

Kim JH, Kim YI, Kim SY, Yoon HJ, Cho KS

  • KMID: 2143158
  • Korean J Med.
  • 1998 Mar;54(3):363-374.
BACKGROUND: Multiple myeloma is a malignant prolif eration of plasma cells producing monoclonal immunog lobulins. The pathogenesis of this disease is still unkno wn. Karyotypic complexity and stepwise disease progre ssion in multiple myeloma...
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