- Genetic Characterization of Molecular Targets in Korean Patients with Gastrointestinal Stromal Tumors
-
Park J, Yoo HM, Sul HJ, Shin S, Lee SW, Kim JG
- KMID: 2471923
- J Gastric Cancer.
- 2020 Mar;20(1):29-40.
- doi: 10.5230/jgc.2020.20.e2
PURPOSE: Gastrointestinal stromal tumors (GISTs) frequently harbor activating gene mutations in either KIT or platelet-derived growth factor receptor A (PDGFRA) and are highly responsive to several selective tyrosine kinase inhibitors.... -
- CITED
-
- Close
- SHARE
-
- Close
- Comprehensive Cancer Panel Sequencing Defines Genetic Diversity and Changes in the Mutational Characteristics of Pancreatic Cancer Patients Receiving Neoadjuvant Treatment
-
Yoon KA, Woo SM, Kim YH, Kong SY, Lee MK, Han SS, Kim TH, Lee WJ, Park SJ
- KMID: 2464315
- Gut Liver.
- 2019 Nov;13(6):683-689.
- doi: 10.5009/gnl18355
BACKGROUND/AIMS: Pancreatic ductal adenocarcinoma (PDA) is associated with an extremely poor prognosis. This study assessed the genetic diversity among patients with PDA and compared their mutational profiles before and after... -
- CITED
-
- Close
- SHARE
-
- Close
- Effect of Relaxin Expression from an Alginate Gel-Encapsulated Adenovirus on Scar Remodeling in a Pig Model
-
Yun IS, Kang E, Ahn HM, Kim YO, Rah DK, Roh TS, Lee WJ, Yun CO
- KMID: 2457481
- Yonsei Med J.
- 2019 Sep;60(9):854-863.
- doi: 10.3349/ymj.2019.60.9.854
PURPOSE: Relaxin (RLX) is a transforming growth factor-β1 (TGF-β1) antagonist that is believed to function as a potent collagen re-arranger and a major suppressor of extracellular matrix components. Adenoviruses (Ads)... -
- CITED
-
- Close
- SHARE
-
- Close
- Discordance of the PAM50 Intrinsic Subtypes Compared with Immunohistochemistry-Based Surrogate in Breast Cancer Patients: Potential Implication of Genomic Alterations of Discordance
-
Kim HK, Park KH, Kim Y, Park SE, Lee HS, Lim SW, Cho JH, Kim JY, Lee JE, Ahn JS, Im YH, Yu JH, Park YH
- KMID: 2464419
- Cancer Res Treat.
- 2019 Apr;51(2):737-747.
- doi: 10.4143/crt.2018.342
PURPOSE: We aimed to analyze the discordance between immunohistochemistry (IHC)-based surrogate subtyping and PAM50 intrinsic subtypes and to assess overall survival (OS) according to discordance. MATERIALS AND METHODS: A total of... -
- CITED
-
- Close
- SHARE
-
- Close
- BRCA1 and Breast Cancer: a Review of the Underlying Mechanisms Resulting in the Tissue-Specific Tumorigenesis in Mutation Carriers
-
Semmler L, Reiter-Brennan C, Klein A
- KMID: 2441847
- J Breast Cancer.
- 2019 Mar;22(1):1-14.
- doi: 10.4048/jbc.2019.22.e6
Since the first cloning of BRCA1 in 1994, many of its cellular interactions have been elucidated. However, its highly specific role in tumorigenesis in the breast tissue—carriers of BRCA1 mutations... -
- CITED
-
- Close
- SHARE
-
- Close
- GAB2 Amplification in Squamous Cell Lung Cancer of Non-Smokers
-
Park YR, Bae SH, Ji W, Seo EJ, Lee JC, Kim HR, Jang SJ, Choi CM
- KMID: 2390304
- J Korean Med Sci.
- 2017 Nov;32(11):1784-1791.
- doi: 10.3346/jkms.2017.32.11.1784
Lung squamous cell cancer (SCC) is typically found in smokers and has a very low incidence in non-smokers, indicating differences in the tumor biology of lung SCC in smokers and... -
- CITED
-
- Close
- SHARE
-
- Close
- Upregulated expression of BCL2, MCM7, and CCNE1 indicate cisplatin-resistance in the set of two human bladder cancer cell lines: T24 cisplatin sensitive and T24R2 cisplatin resistant bladder cancer cell lines
-
Kim SH, Ho JN, Jin H, Lee SC, Lee SE, Hong SK, Lee JW, Lee ES, Byun SS
- KMID: 2363126
- Investig Clin Urol.
- 2016 Jan;57(1):63-72.
- doi: 10.4111/icu.2016.57.1.63
PURPOSE: The mechanism of resistance to cisplatin during treatment of bladder cancer (BC) has been a subject of intense investigation in clinical research. This study aims to identify candidate genes... -
- CITED
-
- Close
- SHARE
-
- Close
- Altered Gene Expression Profile After Exposure to Transforming Growth Factor beta1 in the 253J Human Bladder Cancer Cell Line
-
Lee C, Lee SH, Kim DS, Jeon YS, Lee NK, Lee SE
- KMID: 1794590
- Korean J Urol.
- 2014 Aug;55(8):542-550.
- doi: 10.4111/kju.2014.55.8.542
PURPOSE: Transforming growth factor beta1 (TGF-beta1) inhibits the growth of bladder cancer cells and this effect is prominent and constant in 253J bladder cancer cells. We performed a microarray analysis... -
- CITED
-
- Close
- SHARE
-
- Close
- Developing JSequitur to Study the Hierarchical Structure of Biological Sequences in a Grammatical Inference Framework of String Compression Algorithms
-
Galbadrakh B, Lee KE, Park HS
- KMID: 2053308
- Genomics Inform.
- 2012 Dec;10(4):266-270.
- doi: 10.5808/GI.2012.10.4.266
Grammatical inference methods are expected to find grammatical structures hidden in biological sequences. One hopes that studies of grammar serve as an appropriate tool for theory formation. Thus, we have... -
- CITED
-
- Close
- SHARE
-
- Close
- CaGe: A Web-Based Cancer Gene Annotation System for Cancer Genomics
-
Park YK, Kang TW, Baek SJ, Kim KI, Kim SY, Lee D, Kim YS
- KMID: 2053282
- Genomics Inform.
- 2012 Mar;10(1):33-39.
- doi: 10.5808/GI.2012.10.1.33
High-throughput genomic technologies (HGTs), including next-generation DNA sequencing (NGS), microarray, and serial analysis of gene expression (SAGE), have become effective experimental tools for cancer genomics to identify cancer-associated somatic genomic... -
- CITED
-
- Close
- SHARE
-
- Close
- Tumorigenesis after Injection of Lung Cancer Cell Line (SW-900 G IV) into the Pleural Cavity of Nude Mice
-
Park ES, Kim SM, Kim JI
- KMID: 2063056
- Korean J Thorac Cardiovasc Surg.
- 2010 Dec;43(6):588-595.
BACKGROUND: Base on types of tumor, the types of expressed tumor is diverse and the difference in its expression rate is even more various. Due to such reasons an animal... -
- CITED
-
- Close
- SHARE
-
- Close
- Molecular Imaging of Biological Gene Delivery Vehicles for Targeted Cancer Therapy: Beyond Viral Vectors
-
Min JJ, Nguyen VH, Gambhir SS
- KMID: 2051961
- Nucl Med Mol Imaging.
- 2010 Apr;44(1):15-24.
Cancer persists as one of the most devastating diseases in the world. Problems including metastasis and tumor resistance to chemotherapy and radiotherapy have seriously limited the therapeutic effects of present... -
- CITED
-
- Close
- SHARE
-
- Close
- Chromosomal Losses are Associated with Hypomethylation of the Gene-Control Regions in the Stomach with a Low Number of Active Genes
-
Jung YC, Hong SJ, Kim YH, Kim SJ, Kang SJ, Choi SW, Rhyu MG
- KMID: 1107535
- J Korean Med Sci.
- 2008 Dec;23(6):1068-1089.
- doi: 10.3346/jkms.2008.23.6.1068
Transitional-CpG methylation between unmethylated promoters and nearby methylated retroelements plays a role in the establishment of tissue-specific transcription. This study examined whether chromosomal losses reducing the active genes in cancers... -
- CITED
-
- Close
- SHARE
-
- Close
- Enhancement of Transduction Efficiency and Antitumor Effects of IL-12N220L-expressing Adenovirus by Co-delivery of DOTAP
-
Youn JI, Jin HT, Sung YC
- KMID: 2150635
- Immune Netw.
- 2007 Dec;7(4):179-185.
- doi: 10.4110/in.2007.7.4.179
BACKGROUND: Adenovirus (Ad) vectors have been widely used for many gene therapy applications because of their high transduction ability and broad tropism. However, their utility for cancer gene therapy is... -
- CITED
-
- Close
- SHARE
-
- Close
- An RNA Mapping Strategy to Identify Ribozyme-Accessible Sites on the Catalytic Subunit of Mouse Telomerase
-
Song MS, Lee SW
- KMID: 2166253
- Genomics Inform.
- 2007 Mar;5(1):32-35.
Telomerase reverse transcriptase (TERT) is an enzymatic ribonucleoprotein that prolongs the replicative life span of cells by maintaining protective structures at the ends of eukaryotic chromosomes. Telomerase activity is highly... -
- CITED
-
- Close
- SHARE
-
- Close
- Specificity of Intracellular Trans-Splicing Reaction by hTERT-Targeting Group I Intron
-
Jung HS, Kwon BS, Lee SW
- KMID: 2284678
- Genomics Inform.
- 2005 Dec;3(4):172-174.
Recent anti-cancer approaches have been based to target tumor-specifically associated and/or causative molecules such as RNAs or proteins. As this specifically targeted anti-cancer modulator, we have previously described a novel... -
- CITED
-
- Close
- SHARE
-
- Close
- The Transfection of Cytosine Deaminase Gene and the Cell Killing Effects of Administration of 5-Fluorocytosine in Colon Cancer Cell Lines
-
Cha SW, Chang SK
- KMID: 1896294
- J Korean Surg Soc.
- 2004 Apr;66(4):271-280.
PURPOSE: Among cancer gene therapies, the aims to eliminate malignant cells using genes as drugs as substitutes for conventional therapy, the use of bacterial cytosine deaminase (CD) which can convert... -
- CITED
-
- Close
- SHARE
-
- Close
- The Characterization of CpG Methylation of ERalpha and ERbeta Gene in the Breast Cancer
-
Kim SJ, Kim TW, Lee SY, Park SJ, Lee ES, Kang HS
- KMID: 2173523
- J Korean Breast Cancer Soc.
- 2004 Mar;7(1):8-16.
- doi: 10.4048/jkbcs.2004.7.1.8
PURPOSE: Aberrant methylation of promoter cytosine guanine dinucleotide (CpG) islands is known to be responsible for the alteration and silencing of cancer genes. The data presented here show that most... -
- CITED
-
- Close
- SHARE
-
- Close
- Increased Cytopathic Effect of Replicating Adenovirus Expressing Adenovirus Death Protein
-
Kim E, Kim JH, Koo T, Sohn JH, Yun CO
- KMID: 2166160
- Cancer Res Treat.
- 2003 Oct;35(5):425-432.
PURPOSE: Replication-competent adenoviruses (Ads) are promising new modalities for the treatment of cancer. Selective replication of a viral agent in tumor may lead to improved efficacy over non-replicating Ads due... -
- CITED
-
- Close
- SHARE
-
- Close
- Development of a Conditional Replication Competent Adenovirus, Controlled by the Human Telomerase Promoter (hTERT)
-
Kim E, Kim JH, Shin HY, Lee HS, Sohn JH, Yang JM, Kim J, Yun CO
- KMID: 2166177
- Cancer Res Treat.
- 2003 Jun;35(3):191-206.
PURPOSE: This study has been planned to generate a replication-competent adenovirus which replicates in a cancer cell-specific manner, thus minimizing the side effects and toxicity of cancer gene therapy. MATERIALS... -
- CITED
-
- Close
- SHARE
-
- Close
