- Cancer Gene Therapy
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Kim JH
- KMID: 2349163
- J Korean Med Assoc.
- 1998 Aug;41(8):836-840.
- doi: 10.5124/jkma.1998.41.8.836
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- Cancer Gene Therapy: Limitations and Progress
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Heo DS
- KMID: 2166174
- Cancer Res Treat.
- 2003 Jun;35(3):175-176.
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- Chromosomal Losses are Associated with Hypomethylation of the Gene-Control Regions in the Stomach with a Low Number of Active Genes
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Jung YC, Hong SJ, Kim YH, Kim SJ, Kang SJ, Choi SW, Rhyu MG
- KMID: 1107535
- J Korean Med Sci.
- 2008 Dec;23(6):1068-1089.
- doi: 10.3346/jkms.2008.23.6.1068
Transitional-CpG methylation between unmethylated promoters and nearby methylated retroelements plays a role in the establishment of tissue-specific transcription. This study examined whether chromosomal losses reducing the active genes in cancers... -
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- Developing JSequitur to Study the Hierarchical Structure of Biological Sequences in a Grammatical Inference Framework of String Compression Algorithms
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Galbadrakh B, Lee KE, Park HS
- KMID: 2053308
- Genomics Inform.
- 2012 Dec;10(4):266-270.
- doi: 10.5808/GI.2012.10.4.266
Grammatical inference methods are expected to find grammatical structures hidden in biological sequences. One hopes that studies of grammar serve as an appropriate tool for theory formation. Thus, we have... -
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- Enhanced Growth inhibition by Combined Gene Transfer of p53 and p16INK4a in Adenoviral Vectors to Lung Cancer Cell Lines
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Choi SH, Park KH, Seol JY, Yoo CG, Lee CT, Kim YW, Han SK, Shim YS
- KMID: 2160057
- Tuberc Respir Dis.
- 2001 Jan;50(1):67-75.
- doi: 10.4046/trd.2001.50.1.67
BACKGROUND: Two tumor suppressor genes, p53 and p16, which have different roles in controlling the cell cycle and inducing apoptosis, are frequently inactivated during carcinogenesis including lung cancer. Single tumor... -
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- CaGe: A Web-Based Cancer Gene Annotation System for Cancer Genomics
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Park YK, Kang TW, Baek SJ, Kim KI, Kim SY, Lee D, Kim YS
- KMID: 2053282
- Genomics Inform.
- 2012 Mar;10(1):33-39.
- doi: 10.5808/GI.2012.10.1.33
High-throughput genomic technologies (HGTs), including next-generation DNA sequencing (NGS), microarray, and serial analysis of gene expression (SAGE), have become effective experimental tools for cancer genomics to identify cancer-associated somatic genomic... -
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- Altered Gene Expression Profile After Exposure to Transforming Growth Factor beta1 in the 253J Human Bladder Cancer Cell Line
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Lee C, Lee SH, Kim DS, Jeon YS, Lee NK, Lee SE
- KMID: 1794590
- Korean J Urol.
- 2014 Aug;55(8):542-550.
- doi: 10.4111/kju.2014.55.8.542
PURPOSE: Transforming growth factor beta1 (TGF-beta1) inhibits the growth of bladder cancer cells and this effect is prominent and constant in 253J bladder cancer cells. We performed a microarray analysis... -
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- Upregulated expression of BCL2, MCM7, and CCNE1 indicate cisplatin-resistance in the set of two human bladder cancer cell lines: T24 cisplatin sensitive and T24R2 cisplatin resistant bladder cancer cell lines
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Kim SH, Ho JN, Jin H, Lee SC, Lee SE, Hong SK, Lee JW, Lee ES, Byun SS
- KMID: 2363126
- Investig Clin Urol.
- 2016 Jan;57(1):63-72.
- doi: 10.4111/icu.2016.57.1.63
PURPOSE: The mechanism of resistance to cisplatin during treatment of bladder cancer (BC) has been a subject of intense investigation in clinical research. This study aims to identify candidate genes... -
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- Novel Gap Junction Molecules, Connexin 37, Enhances the Bystander Effect in HSVtk/GCV Gene Therapy
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Kim SY, Yi HK, Lee JC, Hwang DJ, Hwang PH, Lee DY, Cho SC
- KMID: 1606818
- J Korean Pediatr Soc.
- 2003 Jun;46(6):541-547.
PURPOSE: Gap junction intercellular communication(GJIC) is an important mechanism of the bystander effect in herpes simplex thymidine kinase/ganciclovir(HSVtk/GCV) gene therapy Therefore, we attempted to enhance the bystander effect in vitro... -
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- BRCA1 and Breast Cancer: a Review of the Underlying Mechanisms Resulting in the Tissue-Specific Tumorigenesis in Mutation Carriers
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Semmler L, Reiter-Brennan C, Klein A
- KMID: 2441847
- J Breast Cancer.
- 2019 Mar;22(1):1-14.
- doi: 10.4048/jbc.2019.22.e6
Since the first cloning of BRCA1 in 1994, many of its cellular interactions have been elucidated. However, its highly specific role in tumorigenesis in the breast tissue—carriers of BRCA1 mutations... -
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- Molecular Imaging of Biological Gene Delivery Vehicles for Targeted Cancer Therapy: Beyond Viral Vectors
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Min JJ, Nguyen VH, Gambhir SS
- KMID: 2051961
- Nucl Med Mol Imaging.
- 2010 Apr;44(1):15-24.
Cancer persists as one of the most devastating diseases in the world. Problems including metastasis and tumor resistance to chemotherapy and radiotherapy have seriously limited the therapeutic effects of present... -
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- The Characterization of CpG Methylation of ERalpha and ERbeta Gene in the Breast Cancer
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Kim SJ, Kim TW, Lee SY, Park SJ, Lee ES, Kang HS
- KMID: 2173523
- J Korean Breast Cancer Soc.
- 2004 Mar;7(1):8-16.
- doi: 10.4048/jkbcs.2004.7.1.8
PURPOSE: Aberrant methylation of promoter cytosine guanine dinucleotide (CpG) islands is known to be responsible for the alteration and silencing of cancer genes. The data presented here show that most... -
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- Comprehensive Cancer Panel Sequencing Defines Genetic Diversity and Changes in the Mutational Characteristics of Pancreatic Cancer Patients Receiving Neoadjuvant Treatment
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Yoon KA, Woo SM, Kim YH, Kong SY, Lee MK, Han SS, Kim TH, Lee WJ, Park SJ
- KMID: 2464315
- Gut Liver.
- 2019 Nov;13(6):683-689.
- doi: 10.5009/gnl18355
BACKGROUND/AIMS: Pancreatic ductal adenocarcinoma (PDA) is associated with an extremely poor prognosis. This study assessed the genetic diversity among patients with PDA and compared their mutational profiles before and after... -
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- Production of IL-12 from gene modified human dermal fibroblasts: A preclinical study for IL-12 cancer gene therapy
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Park CH, Kang WK, Oh MS, Kim WS, Yang JH, Lotze MT, Kim SY, Park K, Park CH
- KMID: 2128628
- Exp Mol Med.
- 1997 Mar;29(1):65-69.
Cytokine has been used as an immune stimulator and administered to patients for a treatment of cancer. Interleukin-12 (IL-12) is a potent cytokine which acts through a variety of functions... -
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- Genetic Characterization of Molecular Targets in Korean Patients with Gastrointestinal Stromal Tumors
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Park J, Yoo HM, Sul HJ, Shin S, Lee SW, Kim JG
- KMID: 2471923
- J Gastric Cancer.
- 2020 Mar;20(1):29-40.
- doi: 10.5230/jgc.2020.20.e2
PURPOSE: Gastrointestinal stromal tumors (GISTs) frequently harbor activating gene mutations in either KIT or platelet-derived growth factor receptor A (PDGFRA) and are highly responsive to several selective tyrosine kinase inhibitors.... -
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- Telomerase Activity in Laryngeal Papilloma
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Kim CD, Sung MW, Hong SK, Kim KH
- KMID: 2141438
- Korean J Otolaryngol-Head Neck Surg.
- 1997 Oct;40(10):1384-1389.
BACKGROUND: Telomere is derived from Greek words, telos(end) and mere(part). While being located at the end of the chromosome, it contributes to its stability and not only prevents DNA rebonding... -
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- Cell-Specific Growth Inhibition of Human Cervical Cancer Cell by Recombinant Adenovirus p53 in vitro and in vivo
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Bae SM, Kim YW, Yoon JH, Yoo JY, Seo YS, Nam SL, Lee JM, Namkoong S, Kim CK, Kim YW, Ahn WS
- KMID: 2166176
- Cancer Res Treat.
- 2003 Jun;35(3):181-190.
PURPOSE: Despite the significance of the p53 adenoviral vector in cancer gene therapy, an advanced strategy for the development of preferential tumor cell-specific delivery and the long-term persistent gene expression... -
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- Limited Cytotoxic Effect of Adenoviral-mediated p53 Gene Transfer in Variable Non-small Cell Lung Cancer (NSCLC) Cell Lines
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Kim J, Lee SH, Hwang ES, Kim JS, Kim K, Lee JH
- KMID: 2059120
- J Korean Cancer Assoc.
- 1997 Aug;29(4):565-575.
PURPOSE: Cancer gene therapeutic strategy using p53 tumor suppresser gene have been suggested to be effective in many solid tumors including non-small cell lung cancer (NSCLC). To test generalized applicability,... -
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- Discordance of the PAM50 Intrinsic Subtypes Compared with Immunohistochemistry-Based Surrogate in Breast Cancer Patients: Potential Implication of Genomic Alterations of Discordance
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Kim HK, Park KH, Kim Y, Park SE, Lee HS, Lim SW, Cho JH, Kim JY, Lee JE, Ahn JS, Im YH, Yu JH, Park YH
- KMID: 2464419
- Cancer Res Treat.
- 2019 Apr;51(2):737-747.
- doi: 10.4143/crt.2018.342
PURPOSE: We aimed to analyze the discordance between immunohistochemistry (IHC)-based surrogate subtyping and PAM50 intrinsic subtypes and to assess overall survival (OS) according to discordance. MATERIALS AND METHODS: A total of... -
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- An RNA Mapping Strategy to Identify Ribozyme-Accessible Sites on the Catalytic Subunit of Mouse Telomerase
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Song MS, Lee SW
- KMID: 2166253
- Genomics Inform.
- 2007 Mar;5(1):32-35.
Telomerase reverse transcriptase (TERT) is an enzymatic ribonucleoprotein that prolongs the replicative life span of cells by maintaining protective structures at the ends of eukaryotic chromosomes. Telomerase activity is highly... -
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