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Epigenetic Regulation of Cytokine Gene Expression in T Lymphocytes

Lee CG, Sahoo A, Im SH

The developmental program of T helper and regulatory T cell lineage commitment is governed by both genetic and epigenetic mechanisms. The principal events, signaling pathways and the lineage determining factors...
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Overexpression of bone morphogenetic protein 4 in STO fibroblast feeder cells represses the proliferation of mouse embryonic stem cells in vitro

Kim GH, Lee GR, Choi HI, Park NH, Chung HT, Han IS

  • KMID: 1397450
  • Exp Mol Med.
  • 2012 Jul;44(7):457-463.
Embryonic stem cells (ESCs) can be propagated in vitro on feeder layers of mouse STO fibroblast cells. The STO cells secrete several cytokines that are essential for ESCs to maintain...
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