- 14-3-3epsilon protein increases matrix metalloproteinase-2 gene expression via p38 MAPK signaling in NIH3T3 fibroblast cells
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Lee EK, Lee YS, Lee H, Choi CY, Park SH
- KMID: 1058019
- Exp Mol Med.
- 2009 Jul;41(7):453-461.
- doi: 10.3858/emm.2009.41.7.050
One of the 14-3-3 protein isoforms, 14-3-3epsilon, was previously shown to be increased during skin aging. We suggest here a possible role for the 14-3-3epsilon protein in skin aging by... -
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- Regulation of ATP-citrate lyase gene transcription
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Kim KS, Kang JG, Moon YA, Park SW, Kim YS
- KMID: 699895
- Yonsei Med J.
- 1996 Jun;37(3):214-224.
- doi: 10.3349/ymj.1996.37.3.214
It has been suggested that glucose metabolites and insulin are the most important factors inducing ATP-citrate lyase (ACL) by a high carbohydrate diet. We have used a primary culture of... -
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- Regulation of fatty acid synthase at transcriptional and post-transcriptional levels in rat liver
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Kim KS, Park SW, Kim YS
- KMID: 1120230
- Yonsei Med J.
- 1992 Sep;33(3):199-208.
- doi: 10.3349/ymj.1992.33.3.199
The regulation of fatty acid synthase in rat liver was investigated at transcriptional and post-transcriptional levels. When rats were fasted for 3 days and refed on a high-carbohydrate diet, the... -
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- Hydrogenosomal activity of Trichomonas vaginalis cultivated under different iron conditions
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Kim YS, Song HO, Choi IH, Park SJ, Ryu JS
- KMID: 1088770
- Korean J Parasitol.
- 2006 Dec;44(4):373-378.
- doi: 10.3347/kjp.2006.44.4.373
To evaluate whether iron concentration in TYM medium influence on hydrogenosomal enzyme gene expression and hydrogenosomal membrane potential of Trichomonas vaginalis, trophozoites were cultivated in irondepleted, normal and iron-supplemented TYM... -
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- Pim-1: A serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis
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Wang Z, Bhattacharya N, Weaver M, Petersen K, Meyer M, Gapter L, Magnuson N
- KMID: 1119212
- J Vet Sci.
- 2001 Dec;2(3):167-179.
Pim-1 belongs to a family of serine/threonine protein kinases that are highly conserved through evolution in multicellular organisms. Originally identified from moloney murine leukemia virus (MuLV)-induced T-cell lymphomas in mice,... -
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- Hydrogen peroxide mediates doxorubicin-induced transglutaminase 2 expression in PC-14 human lung cancer cell line
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Han JA, Park SC
- KMID: 1029936
- Exp Mol Med.
- 1999 Jun;31(2):83-88.
Increased expression of Transglutaminases 2 (TGase 2, TGase C) was observed in PC-14 human lung cancer cells in association with doxorubicin resistance and the reduction of the enzyme expression was correlated with... -
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- Differential changes in the expression of cyclic nucleotide phosphodiesterase isoforms in rat brains by chronic treatment with electroconvulsive shock
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Cho CH, Cho DH, Seo MR, Juhnn YS
- KMID: 755073
- Exp Mol Med.
- 2000 Sep;32(3):110-114.
Electroconvulsive shock (ECS) has been suggested to affect cAMP signaling pathways to exert therapeutic effects. ECS was recently reported to increase the expression of PDE4 isoforms in rat brain,... -
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- Expression of MT-1 MMP, MMP2, MMP9 and TIMP2 mRNAs in Ductal Carcinoma in Situ and Invasive Ductal Carcinoma of the Breast
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Kim HJ, Park CI, Park BW, Lee HD, Jung WH
- KMID: 1715851
- Yonsei Med J.
- 2006 Jun;47(3):333-342.
- doi: 10.3349/ymj.2006.47.3.333
We investigated the expression of membrane type-1 (MT1)-MMP, MMP2, MMP9 and TIMP2 mRNAs and their roles in ductal carcinoma in situ (DCIS) and T1 and T2 invasive ductal carcinoma of... -
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- Regulation of expression of matrix metalloproteinase-9 by JNK in Raw 264.7 cells: presence of inhibitory factor(s) suppressing MMP-9 induction in serum and conditioned media
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Lee YS, Lan Tran H, Van Ta Q
- KMID: 1088601
- Exp Mol Med.
- 2009 Apr;41(4):259-268.
- doi: 10.3858/emm.2009.41.4.029
Matrix metalloproteinase-9 (MMP-9) secreted from macrophages plays an important role in tissue destruction and inflammation through degradation of matrix proteins and proteolytic activation of cytokines/chemokines. Whereas the MEK-ERK and PI3K-Akt... -
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- Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases
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Patel MS, Korotchkina LG
- KMID: 1457529
- Exp Mol Med.
- 2001 Dec;33(4):191-197.
This review summarizes the recent developments on the regulation of human pyruvate dehydrogenase complex (PDC) by site-specific phosphorylation by four kinases. Mutagenic analysis of the three phosphorylation sites of human... -
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- Regulation of matrix metalloproteinase-9 protein expression by 1alpha,25-(OH)2D3 during osteoclast differentiation
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Gu JH, Tong XS, Chen GH, Liu XZ, Bian JC, Yuan Y, Liu ZP
- KMID: 1737619
- J Vet Sci.
- 2014 Mar;15(1):133-140.
- doi: 10.4142/jvs.2014.15.1.133
To investigate 1alpha,25-(OH)2D3 regulation of matrix metalloproteinase-9 (MMP-9) protein expression during osteoclast formation and differentiation, receptor activator of nuclear factor kappaB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) were administered... -
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- Enhanced tyrosine hydroxylase expression in PC12 cells co-cultured with feline mesenchymal stem cells
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Jin GZ, Yin XJ, Yu XF, Cho SJ, Lee HS, Lee HJ, Kong IK
- KMID: 1106218
- J Vet Sci.
- 2007 Dec;8(4):377-382.
- doi: 10.4142/jvs.2007.8.4.377
Mesenchymal stem cells (MSCs) secrete a variety of neuroregulatory molecules, such as nerve growth factor, brain-derived neurotrophic factor, and glial cell-derived neurotrophic factor, which upregulate tyrosine hydroxylase (TH) gene expression... -
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- Role of tissue inhibitors of metalloproteinases (TIMPs) in colorectal carcinoma
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Joo YE, Seo KS, Kim J, Kim HS, Rew JS, Park CS, Kim SJ
- KMID: 1731316
- J Korean Med Sci.
- 1999 Aug;14(4):417-423.
- doi: 10.3346/jkms.1999.14.4.417
Increased production of matrix metalloproteinases (MMPs) has been associated with increases in invasive and metastatic potential in many types of human carcinoma. Tissue inhibitors of metalloproteinase (TIMP)-1 inhibits most interstitial... -
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- The Ketogenic Diet Suppresses the Cathepsin E Expression Induced by Kainic Acid in the Rat Brain
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Jeong HJ, Kim H, Kim YK, Park SK, Kang DW, Yoon D
- KMID: 1071415
- Yonsei Med J.
- 2010 Sep;51(5):653-660.
- doi: 10.3349/ymj.2010.51.5.653
PURPOSE: The ketogenic diet has long been used to treat epilepsy, but its mechanism is not yet clearly understood. To explore the potential mechanism, we analyzed the changes in gene... -
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- Expression and Regulation of Endothelial Nitric Oxide Synthase by Vascular Endothelial Growth Factor in ECV 304 Cells
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Park JS, Hong GR, Baek SW, Shin DG, Kim YJ, Shim BS
- KMID: 648670
- J Korean Med Sci.
- 2002 Apr;17(2):161-167.
- doi: 10.3346/jkms.2002.17.2.161
Nitric oxide (NO) seems to play a pivotal role in the vascular endothelial growth factor (VEGF)-induced endothelial cell proliferation. This study was designed to investigate the role and intracellular signal... -
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- Expression of hOGG1 protein during differentiation of HL-60 cells
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Lee YS, Lee KH, Chung MH
- KMID: 1097257
- Exp Mol Med.
- 2003 Apr;35(2):98-105.
Human 8-oxo-G-DNA glycosylase 1 (hOGG1) is a DNA glycosylase to cleave 8-oxo-7,8-dihydroguanine (8-oxo-G), a mutagenic DNA adduct formed by oxidant stresses. Here, we examined hOGG1 protein expression and repair activity... -
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- Effect of Nitric Oxide on the Expression of Matrix Metalloproteinase and Its Association with Migration of Cultured Trabecular Meshwork Cells
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Kim JW
- KMID: 2363893
- Korean J Ophthalmol.
- 2016 Feb;30(1):66-75.
- doi: 10.3341/kjo.2016.30.1.66
PURPOSE: To determine the effect of exogenous nitric oxide (NO) on the migration of trabecular meshwork (TM) cells and its association with expression of matrix metalloproteinases (MMPs). METHODS: Primary human TM... -
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- Triptolide inhibits ovarian cancer cell invasion by repression of matrix metalloproteinase 7 and 19 and upregulation of E-cadherin
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Zhao H, Yang Z, Wang X, Zhang X, Wang M, Wang Y, Mei Q, Wang Z
- KMID: 1401755
- Exp Mol Med.
- 2012 Nov;44(11):633-641.
Triptolide, a compound extracted from the traditional Chinese medicine preparation of Tripterygium wilfordii Hook F., has been reported to have anti-inflammatory and anti-cancer activities. However, its effect on ovarian cancer... -
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- Impacts of Cytosolic Phospholipase A2, 15-Prostaglandin Dehydrogenase, and Cyclooxygenase-2 Expressions on Tumor Progression in Colorectal Cancer
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Lim SC, Cho H, Lee TB, Choi CH, Min YD, Kim SS, Kim KJ
- KMID: 1071420
- Yonsei Med J.
- 2010 Sep;51(5):692-699.
- doi: 10.3349/ymj.2010.51.5.692
PURPOSE: In addition to cyclooxygenase-2 (COX-2) which is related to prostaglandin E2 synthesis, other enzymes such as cytosolic phospholipase A2 (cPLA2), microsomal prostaglandin E2 synthase-1 (mPGES-1), and 15-prostaglandin dehydrogenase (15-PGDH)... -
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- Matrix metalloproteinases in human gliomas: activation of matrix metalloproteinase-2 (MMP-2) may be correlated with membrane-type-1 matrix metalloproteinase (MT1-MMP) expression
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Hur JH, Park MJ, Park IC, Yi DH, Rhee CH, Hong SI, Lee SH
- KMID: 1128630
- J Korean Med Sci.
- 2000 Jun;15(3):309-314.
- doi: 10.3346/jkms.2000.15.3.309
To evaluate possible roles of matrix metalloproteinase (MMP)-1, -2, tissue inhibitor of metalloproteinase (TIMP)-1, -2 and membrane-type-1 matrix metalloproteinase (MT1-MMP) in invasion of human gliomas, expressions of these proteins were... -
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