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Interleukin-10 is increased in successful drug desensitization regardless of the hypersensitivity reaction type

Gelincik A, Demir S, Şen F, Bozbey UH, Olgaç M, Ünal D, Çolakoğlu B, Aktaş EC, Deniz G, Büyüköztürk S

BACKGROUND: Little is known about the mechanism of desensitization in hypersensitivity drug reactions. OBJECTIVE: The aim of this study was to evaluate the effects of drug desensitization on some cytokine levels...
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An unusual dual hypersensitivity reaction to moxifloxacin in a patient

Demir S, Unal D, Olgac M, Akdeniz N, Aktas-Cetin E, Gelincik A, Colakoglu , Buyukozturk S

Both immediate and nonimmediate type hypersensitivity reactions (HRs) with a single dose of quinolone in the same patient have not been previously reported. A 47-year-old female patient referred to us...
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Evaluation of the left venticular systolic function with the measurement of global longitudinal strain by Speckle tracking echocardiography in anaphylaxis

Demir S, Atici A, Coskun R, Olgac M, Unal D, Sarikaya R, Gelincik A, Colakoglu , Oflaz H, Sonsoz MR, Buyukozturk S

BACKGROUND: It is not known how cardiac functions are affected during anaphylaxis. OBJECTIVE: Our aim was to measure the cardiac functions shortly after an anaphylaxis attack using a new technique that...
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Usefulness of In Vivo and In Vitro Diagnostic Tests in the Diagnosis of Hypersensitivity Reactions to Quinolones and in the Evaluation of Cross-Reactivity: A Comprehensive Study Including the Latest Quinolone Gemifloxacin

Demir S, Gelincik A, Akdeniz N, Aktas-Cetin E, Olgac M, Unal D, Ertek B, Coskun R, ColakoÄŸlu B, Deniz G, Buyukozturk S

PURPOSE: Reports evaluating diagnosis and cross reactivity of quinolone hypersensitivity have revealed contradictory results. Furthermore, there are no reports investigating the cross-reactivity between gemifloxacin (GFX) and the others. We aimed...
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Impact of high serum Immunoglobulin E levels on the risk of atherosclerosis in humans

Unal D, Gelincik A, Elitok A, Demir S, Olgac M, Coskun R, Kocaaga M, Colakoglu , Buyukozturk S

BACKGROUND: Epidemiological studies show that immunoglobulin E (IgE) levels were higher in subjects with acute coronary events. However, it is unknown if the increased IgE level is a marker of...
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