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Cumulative Exposure to High γ-Glutamyl Transferase Level and Risk of Diabetes: A Nationwide Population-Based Study

Park JY, Han K, Kim HS, Cho JH, Yoon KH, Kim MK, Lee SH

Background: Elevated γ-glutamyl transferase (γ-GTP) level is associated with metabolic syndrome, impaired glucose tolerance, and insulin resistance, which are risk factors for type 2 diabetes. We aimed to investigate the...
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Association between Variability of Metabolic Risk Factors and Cardiometabolic Outcomes

Park MJ, Choi KM

Despite strenuous efforts to reduce cardiovascular disease (CVD) risk by improving cardiometabolic risk factors, such as glucose and cholesterol levels, and blood pressure, there is still residual risk even in...
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The Predictive Value of Pre-therapeutic Serum Gamma-glutamyl transferase in Efficacy and Adverse Reactions to Neoadjuvant Chemotherapy among Breast Cancer Patients

Sun L, Yin W, Wu Z, Wang Y, Lu J

Purpose: Gamma-glutamyl transferase (GGT) has been reported as being involved in tumor progression. Previous studies documented a potential relationship between serum GGT level and survival outcome in several types of...
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Liver Enzymes and Risk of Stroke: The Atherosclerosis Risk in Communities (ARIC) Study

Ruban A, Daya N, Schneider AL, Gottesman R, Selvin E, Coresh J, Lazo M, Koton S

Background and Purpose Liver enzymes (aspartate aminotransferase [AST], alanine aminotransferase [ALT], and gamma-glutamyl transpeptidase [GGT]) are glutamate-regulatory enzymes, and higher glutamate levels correlated with worse prognosis of patients with neurotrauma....
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Association between Serum Gamma-Glutamyltransferase and Prevalence of Metabolic Syndrome Using Data from the Korean Genome and Epidemiology Study

Lee MY, Hyon DS, Huh JH, Kim HK, Han SK, Kim JY, Koh SB

BACKGROUND: The aim of this study was to determine whether there is a positive correlation between gamma-glutamyltransferase (GGT) levels and the prevalence of metabolic syndrome and whether GGT can be...
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Serum alkaline phosphatase and γ-glutamyl transferase in acute pyelonephritis

Han C, Lee YK, Park HC, Cho A, Choi SR, Yoon JW, Koo JR, Kim HJ, Noh JW, Park MJ

BACKGROUND: Elevated serum alkaline phosphatase (AP) and γ-glutamyl transferase (γ-GT) are commonly observed in patients with acute pyelonephritis. The goal of this study was to examine the clinical significance of...
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Mercury Exposure in Association With Decrease of Liver Function in Adults: A Longitudinal Study

Choi J, Bae S, Lim H, Lim JA, Lee YH, Ha M, Kwon HJ

OBJECTIVES: Although mercury (Hg) exposure is known to be neurotoxic in humans, its effects on liver function have been less often reported. The aim of this study was to investigate...
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Diagnostic value of alcoholic liver disease (ALD)/nonalcoholic fatty liver disease (NAFLD) index combined with γ-glutamyl transferase in differentiating ALD and NAFLD

Wang J, Li P, Jiang Z, Yang Q, Mi Y, Liu Y, Shi R, Zhou Y, Wang J, Lu W, Li S, Liu D

BACKGROUND/AIMS: This study aimed to verify the reliability of the alcoholic liver disease (ALD)/nonalcoholic fatty liver disease (NAFLD) index (ANI) for distinguishing ALD in patients with hepatic steatosis from NAFLD,...
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Serum γ-Glutamyl Transferase Is Inversely Associated with Bone Mineral Density Independently of Alcohol Consumption

Choi HS, Kim KJ, Rhee Y, Lim SK

BACKGROUND: γ-Glutamyl transferase (GGT) is a well-known marker of chronic alcohol consumption or hepatobiliary diseases. A number of studies have demonstrated that serum levels of GGT are independently associated with...
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Risks of borderline liver enzyme abnormalities to the incidence of impaired fasting glucose and diabetes mellitus: a 7 year follow up study of workers

Yu JH, Kim JS, Lee MR, Yoon SY, Cho SY, Yoo SH, Kim BI

BACKGROUND: The aim of this study was to identify the relationships between borderline serum liver enzyme abnormalities and the incidence of impaired fasting glucose (IFG) and diabetes mellitus (DM) during...
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Drinking Amount Associated with Abnormal Gamma-Glutamyl Transpeptidase Expression in Women

Yang JS, Kim JS, Seo WY, Paik SC

BACKGROUND: This study investigated whether there is any difference in drinking amount associated with abnormal expression of gamma-glutamyl transpeptidase (GGT), one of the biological markers of excessive drinking, between flushing...
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Gender Differences in the Association between Serum gamma-Glutamyltransferase and Blood Pressure Change: A Prospective Community-Based Cohort Study

Ha KH, Kim HC, Park S, Ihm SH, Lee HY

We evaluated the gender differences in the relation of baseline serum gamma-glutamyltransferase (GGT) levels to blood pressure (BP) change during 4 yr. 4,025 normotensive subjects (1,945 men and 2,080 women)...
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Higher Serum Heavy Metal May Be Related with Higher Serum gamma-Glutamyltransferase Concentration in Koreans: Analysis of the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V-1, 2, 2010, 2011)

Kim SJ, Han SW, Lee DJ, Kim KM, Joo NS

BACKGROUND: Abnormal serum gamma-glutamyltransferase (gamma-GT) may be an early and sensitive marker for oxidative stress. This study was performed to evaluate the association between serum heavy metals and gamma-GT concentration. METHODS:...
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Association between long working hours and serum gamma-glutamyltransferase levels in female workers: data from the fifth Korean National Health and Nutrition Examination Survey (2010-2011)

Park SG, Lee YJ, Ham JO, Jang EC, Kim SW, Park H

OBJECTIVES: The present study investigated the association between long working hours and serum gamma-glutamyltransferase (GGT) levels, a factor influencing the incidence of cardiovascular disease. METHODS: Data from the fifth Korean National...
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Clinical Characteristics of Primary Epstein Barr Virus Hepatitis with Elevation of Alkaline Phosphatase and gamma-Glutamyltransferase in Children

Yang SI, Geong JH, Kim JY

PURPOSE: The aim of the present study was to evaluate the clinical characteristics of the primary Epstein-Barr virus (EBV) hepatitis with elevation of both serum alkaline phosphatase (ALP) and gamma-glutamyltransferase...
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Effects of Providing Health Education to Workers for the Management of Liver Disease Screened by Periodic Health Surveys

Lee MR, Kim JS

  • KMID: 2270337
  • Korean J Occup Health Nurs.
  • 2013 Nov;22(4):324-333.
PURPOSE: This study was conducted to compare the changes in the levels of liver enzymes after providing health education to workers. METHODS: Among 909 electronics-manufacturing workers, 96 (10.6%) workers had abnormal...
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Association of Serum gamma-Glutamyltransferase Level and Incident Prehypertension in Korean Men

Chun H, Park SK, Ryoo JH

Several lines of evidence indicate that prehypertension is more atherogenic than normal blood pressure. Serum gamma-glutamyltransferase (GGT) is known to be positively associated with prehypertensive status and the progression of...
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The Association between Serum Gamma-glutamyltransferase within Normal Range and Risk Factors of Cardiovascular Diseases: Based on the Framingham Risk Score

Ko HJ, Choi CS, Youn CH, Lee DH, Lee SG

  • KMID: 2271009
  • Korean J Obes.
  • 2013 Mar;22(1):21-29.
BACKGROUND: We investigated the association between serum GGT level with risk factors of cardiovascular diseases and the Framingham risk score (FRS). METHODS: A Total of 712 subjects (men 160, women 552)...
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A Lower Serum Gamma-Glutamyltransferase Level Does Not Predict a Sustained Virological Response in Patients with Chronic Hepatitis C Genotype 1

Guzelbulut F, Sezikli M, Cetinkaya , Ozkara S, Gonen C, Ovunc AO

  • KMID: 2053518
  • Gut Liver.
  • 2013 Jan;7(1):74-81.
BACKGROUND/AIMS: Low gamma-glutamyltransferase (GGT) level was shown to be an independent predictor of a sustained virological response (SVR) in chronic hepatitis C. We aimed to determine factors associated with high...
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Relationship between Serum Gamma-glutamyltransferase Levels within Reference Intervals and the Prevalence of Metabolic Syndrome and Diabetes Mellitus in Adults

Choi MS, Bae TW, Lee JH, Cho YG, Lee HS, Choi SI, Kim DS

BACKGROUND: This study was conducted to establish reference intervals (RIs) for serum gamma-glutamyltransferase (GGT), and to evaluate the association between serum GGT levels within RIs and the prevalence of metabolic...
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