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RGS Proteins and Opioid Signaling

Kim KS, Palmer PP, Kim KJ

The regulators of the G protein signaling (RGS) proteins are responsible for the rapid acceleration of the GTPase-activity intrinsic to the heterotrimeric G protein alpha subunits. As GTPase-activating proteins (GAP),...
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Characterization of the Rho GTPase-Activating Protein RhoGAP68F

Nahm M, Lee S

Rho small GTPases control multiple aspects of neuronal morphogenesis by regulating the assembly and organization of the actin cytoskeleton. Although they are negatively regulated by GTPase activating proteins (GAPs), the...
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The role of the exocyst in renal ciliogenesis, cystogenesis, tubulogenesis, and development

Lipschutz

The exocyst is a highly conserved eight-subunit protein complex (EXOC1–8) involved in the targeting and docking of exocytic vesicles translocating from the trans-Golgi network to various sites in renal cells....
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The Effect of PLCgamma1 Pleckstrin Homology Domain on Il - 6 - induced B Cell Response

Pyun KH, Choi IP, Han MY, Yoon SY, Song HK, Lee HY

  • KMID: 1548377
  • Korean J Immunol.
  • 1997 Dec;19(4):525-532.
The pleckstrin homology (PH) domain is a protein module of approximately 100 amino acids, that has been found in signaling molecules, including serinelthreonine kinase, GTPase-activating protein, phospholipase, and some cytoskeletal...
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IQGAP1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation by Akt activation

Chen F, Zhu HH, Zhou LF, Wu SS, Wang J, Chen Z

The scaffold protein IQGAP1 shows elevated levels in several cancer types, but its expression in hepatocellular carcinoma is unknown. We found that 58% of human hepatocellular carcinoma tissue samples had...
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Mutational Analysis of the NF1 Gene in Two Families with Neurofibromatosis 1 Accompanied by Pheochromocytoma

Yi HS, Kim SH, Kim J, Bae EJ, Hong S, Park IB, Kim YJ, Lee S

Neurofibromatosis type 1 (NF1) is one of the most common autosomal dominant inherited disorders affecting the nervous system. NF1 is associated with mutations in the NF1 gene, which is located...
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Analysis of HPV-16 E6-related gene expression using cDNA microarray

Myeong J, Rha SY, Lee MJ, Um SJ, Namkoong S, Park JS

  • KMID: 2270643
  • Korean J Obstet Gynecol.
  • 2002 Dec;45(12):2280-2288.
OBJECTIVE: To examine the effect of HPV-16 E6 expression on the transcription of cellular genes, we used cDNA microarray in HPV-16 E6 transfected stable cancer cell lines. METHODS: Using cDNA microarray...
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In vivo determination of the gap2 gene promoter activity in Giardia lamblia

Yang HW, Kim J, Yong TS, Park SJ

A shuttle vector for Escherichia coli and Giardia lamblia was modified to produce a reporter plasmid, which monitors the expression of prescribed gene in G. lamblia by measuring its luciferase...
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