- The proteins of synaptic vesicle membranes are affected during ageing of rat brain
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Lee SR, Kim AR, Kim JS, Kim JB, Lee JY, Lee YL, Choe M, Park JB
- KMID: 1457533
- Exp Mol Med.
- 2001 Dec;33(4):220-225.
Low molecular weight GTP-binding proteins are molecular switches that are believed to play pivotal roles in cell growth, differentiation, cytoskeletal organization, and vesicular trafficking. Rab proteins are key players in... -
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- G protein signaling in the parasite Entamoeba histolytica
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Bosch DE, Siderovski DP
- KMID: 2154234
- Exp Mol Med.
- 2013 Mar;45(3):e15.
The parasite Entamoeba histolytica causes amebic colitis and systemic amebiasis. Among the known amebic factors contributing to pathogenesis are signaling pathways involving heterotrimeric and Ras superfamily G proteins. Here, we... -
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- The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5
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Park MH, Choi KY, Min DS
- KMID: 2359887
- Exp Mol Med.
- 2015 Dec;47(12):e200.
- doi: 10.1038/emm.2015.101
Endocytosis is differentially regulated by hypoxia-inducible factor-1alpha (HIF-1alpha) and phospholipase D (PLD). However, the relationship between HIF-1alpha and PLD in endocytosis is unknown. HIF-1alpha is degraded through the prolyl hydroxylase... -
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- Phytosphingosine-1-phosphate stimulates chemotactic migration of L2071 mouse fibroblasts via pertussis toxin-sensitive G-proteins
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Kim MK, Park KS, Lee H, Kim YD, Yun J, Bae YS
- KMID: 1094659
- Exp Mol Med.
- 2007 Apr;39(2):185-194.
Phytosphingosine-1-phosphate (PhS1P) was found to stimulate an intracellular calcium increase via phospholipase C but not pertussis toxin (PTX)- sensitive G-proteins in L2071 mouse fibroblasts. PhS1P also activated ERK and p38... -
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- Rac-mediated actin remodeling and myosin II are involved in KATP channel trafficking in pancreatic beta-cells
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Han YE, Lim A, Park SH, Chang S, Lee SH, Ho WK
- KMID: 2160621
- Exp Mol Med.
- 2015 Oct;47(10):e190.
- doi: 10.1038/emm.2015.72
AMP-activated protein kinase (AMPK) is a metabolic sensor activated during metabolic stress and it regulates various enzymes and cellular processes to maintain metabolic homeostasis. We previously reported that activation of... -
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- TNF-alpha-induced up-regulation of intercellular adhesion molecule-1 is regulated by a Rac-ROS-dependent cascade in human airway epithelial cells
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Kim H, Hwang JS, Woo CH, Kim EY, Kim TH, Cho KJ, Kim JH, Seo JM, Lee SS
- KMID: 1052939
- Exp Mol Med.
- 2008 Apr;40(2):167-175.
- doi: 10.3858/emm.2008.40.2.167
Up-regulation of intercellular adhesion molecule-1 (ICAM-1) in the lung airway epithelium is associated with the epithelium-leukocyte interaction, critical for the pathogenesis of various lung airway inflammatory diseases such as asthma.... -
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- Transglutaminase 2 inhibits apoptosis induced by calciumoverload through down-regulation of Bax
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Cho SY, Lee JH, Bae HD, Jeong EM, Jang GY, Kim CW, Shin DM, Jeon JH, Kim IG
- KMID: 983956
- Exp Mol Med.
- 2010 Sep;42(9):639-650.
- doi: 10.3858/emm.2010.42.9.063
An abrupt increase of intracellular Ca2+ is observed in cells under hypoxic or oxidatively stressed conditions. The dysregulated increase of cytosolic Ca2+ triggers apoptotic cell death through mitochondrial swelling and... -
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