- Evaluation of Neutrophil Activation Status According to the Phenotypes of Adult Asthma
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Kim SH, Uuganbayar U, Trinh HK, Pham D, Kim N, Kim M, Sohn H, Park HS
- KMID: 2442049
- Allergy Asthma Immunol Res.
- 2019 May;11(3):381-393.
- doi: 10.4168/aair.2019.11.3.381
PURPOSE: Neutrophils are considered key effector cells in the pathogenic mechanisms of airway inflammation in asthma. This study assessed the activation status of neutrophils in adult asthmatics, and the therapeutic... -
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- Changes in the Multiple Sclerosis Treatment Paradigm. What Do We Do Now and What Were We Doing Before?
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Alonso R, Eizaguirre MB, Zavala L, Pita C, Silva B, Garcea O
- KMID: 2424176
- J Clin Neurol.
- 2018 Oct;14(4):487-491.
- doi: 10.3988/jcn.2018.14.4.487
BACKGROUND AND PURPOSE: The number of disease-modifying drugs (DMDs) available for treating relapsing-remitting multiple sclerosis is increasing. Numerous drugs have been approved since 2010 in South America, which has increased... -
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- Plasmacytoid Dendritic Cells Contribute to the Protective Immunity Induced by Intranasal Treatment with Fc-fused Interleukin-7 against Lethal Influenza Virus Infection
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Kang MC, Park HW, Choi DH, Choi YW, Park Y, Sung YC, Lee SW
- KMID: 2400639
- Immune Netw.
- 2017 Oct;17(5):343-351.
- doi: 10.4110/in.2017.17.5.343
Developing a novel vaccine that can be applied against multiple strains of influenza virus is of utmost importance to human health. Previously, we demonstrated that the intranasal introduction of Fc-fused... -
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- Clonal Expansion of Allergen-specific CD4⺠T Cell in the Lung in the Absence of Lymph Nodes
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Choi G, Kim BS, Park YJ, Shim I, Chung Y
- KMID: 2383354
- Immune Netw.
- 2017 Jun;17(3):163-170.
- doi: 10.4110/in.2017.17.3.163
The expansion of allergen-specific CD4⺠T cells is a critical step in inducing airway inflammation during allergic asthma. Such clonal expansion of T cells is initiated through the interaction between... -
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- Sphingosine 1-Phosphate Receptor Modulators and Drug Discovery
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Park SJ, Im DS
- KMID: 2367621
- Biomol Ther.
- 2017 Jan;25(1):80-90.
- doi: 10.4062/biomolther.2016.160
Initial discovery on sphingosine 1-phosphate (S1P) as an intracellular second messenger was faced unexpectedly with roles of S1P as a first messenger, which subsequently resulted in cloning of its G... -
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- Oral Disease-Modifying Therapies for Multiple Sclerosis
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Kim W, Zandona ME, Kim SH, Kim HJ
- KMID: 2179567
- J Clin Neurol.
- 2015 Jan;11(1):9-19.
- doi: 10.3988/jcn.2015.11.1.9
Classical multiple sclerosis (MS) treatments using first-line injectable drugs, although widely applied, remain a major concern in terms of therapeutic adherence and efficacy. New oral drugs recently approved for MS... -
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- Bone marrow stem/progenitor cell mobilization in C57BL/6J and BALB/c mice
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Lee H, Che JH, Oh JE, Chung SS, Jung HS, Park KS
- KMID: 2312115
- Lab Anim Res.
- 2014 Mar;30(1):14-20.
Bone marrow (BM) has been considered as a reservoir of stem/progenitor cells which are able to differentiate into ectodermal, endodermal, and mesodermal origins in vitro as well as in vivo.... -
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- Intercellular Lipid Mediators and GPCR Drug Discovery
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Im DS
- KMID: 2170658
- Biomol Ther.
- 2013 Nov;21(6):411-422.
G-protein-coupled receptors (GPCR) are the largest superfamily of receptors responsible for signaling between cells and tissues, and because they play important physiological roles in homeostasis, they are major drug targets.... -
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- Interferon beta-1b Treatment in a Korean Girl with Multiple Sclerosis
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Kim HJ, Kim HD, Lee JS, Kang HC
- KMID: 2329623
- J Korean Child Neurol Soc.
- 2013 Mar;21(1):28-32.
Here we report a case of pediatric multiple sclerosis treated with interferon beta-1b. Interferon beta is widely used in adult patients with multiple sclerosis (MS). However, its effects and safety... -
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- Challenges and Pitfalls of Stroke Therapeutics Research
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Jung KH
- KMID: 2288739
- Korean J Stroke.
- 2011 Apr;13(1):11-15.
Ischemia-reperfusion injury is complicated with multiple injury pathways. If a particular agent is used to restore blood flow and prevent cell death, many damaged neurons may come back to life.... -
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