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How to optimize the diagnostic yield of endoscopic ultrasoundguided fine-needle sampling in solid pancreatic lesions from a technical perspective

Kim NH, Kim HJ

Endoscopic ultrasound-guided fine-needle aspiration is currently the gold standard in the diagnosis of solid pancreatic lesions, with high diagnostic accuracy. However, this technique is demanding, as its diagnostic yield and...
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Evaluation of the Role of Axillary Lymph Node Fine-Needle Aspiration Cytology in Early Breast Cancer With or Without Neoadjuvant Chemotherapy

Takatsuka D, Yoshimura A, Sawaki M, Hattori M, Kotani H, Kataoka A, Horisawa N, Ozaki Y, Endo Y, Nozawa K, Iwata H

Purpose: Fine-needle aspiration cytology (FNAC) of axillary lymph nodes (AxLNs) is performed to diagnose nodal metastasis in patients with breast cancer. Although the sensitivity of ultrasound-guided FNAC for identifying AxLN...
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Combined fine-needle aspiration with core needle biopsy for assessing thyroid nodules: a more valuable diagnostic method?

Chen Z, Wang Jj, Guo Dm, Zhai Yx, Dai Zz, Su Hh

Purpose: This study aimed to evaluate the diagnostic value of combined fine-needle aspiration (FNA) with core needle biopsy (CNB) in thyroid nodules. Methods: FNA and CNB were performed simultaneously on 703...
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Factors Affecting the Learning Curve in the Endoscopic Ultrasound-Guided Sampling of Solid Pancreatic Lesions: A Prospective Study

Razpotnik M, Bota S, Kutilek M, Essler G, Urak C, Prosenz J, Weber-Eibel J, Maieron A, Peck-Radosavljevic M

Background/Aims: Endosonography is associated with a long learning curve. We aimed to assess variables that may influence the diagnostic outcomes in endoscopic ultrasound-guided fine-needle aspiration/biopsy (EUS-FNA/B) of solid pancreatic tumors...
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Tissue Quality Comparison Between Heparinized Wet Suction and Dry Suction in Endoscopic Ultrasound-Fine Needle Biopsy of Solid Pancreatic Masses: A Randomized Crossover Study

Lin MY, Wu CL, Su YY, Huang CJ, Chang WL, Sheu BS

Background/Aims: A high-quality sample allows for next-generation sequencing and the administration of more tailored precision medicine treatments. We aimed to evaluate whether heparinized wet suction can obtain higher quality samples...
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A Comprehensive Assessment of the Harms of Fine-Needle Aspiration Biopsy for Thyroid Nodules: A Systematic Review

Park JY, Choi W, Hong AR, Yoon JH, Kim HK, Kang HC

Background: There have concerns related with the potential harms of fine-needle aspiration biopsy (FNAB). We aimed to summarize the clinical complications and evaluate the safety of FNAB. Methods: Studies related with...
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Clinical Application of the 2021 Korean Thyroid Imaging Reporting and Data System (K-TIRADS)

Na DG

In patients with thyroid nodules, ultrasonography (US) has been established as a primary diagnostic imaging method and is essential for treatment decision. The Korean Thyroid Imaging Reporting and Data System...
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A multicenter comparative study of endoscopic ultrasound-guided fine-needle biopsy using a Franseen needle versus conventional endoscopic ultrasound-guided fine-needle aspiration to evaluate microsatellite instability in patients with unresectable pancreatic cancer

Takagi T, Sugimoto M, Imamura H, Takahata Y, Nakajima Y, Suzuki R, Konno N, Asama H, Sato Y, Irie H, Nakamura J, Takasumi M, Hashimoto M, Kato T, Kobashi R, Hashimoto Y, Shibukawa G, Marubashi S, Hikichi T, Ohira H

Background/Aims: Immune checkpoint blockade has recently been reported to be effective in treating microsatellite instability (MSI)-high tumors. Therefore, sufficient sampling of histological specimens is necessary in cases of unresectable pancreatic...
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Diagnosis of parathyroid incidentaloma detected on thyroid ultrasonography: the role of fine-needle aspiration cytology and washout parathyroid hormone measurements

Lee B, Chung SR, Choi YJ, Sung TY, Song DE, Kim TY, Lee JH, Baek JH

Purpose: The aim of this study was to assess the diagnostic role of fine-needle aspiration cytology (FNAC) and analyze factors associated with false-negative FNAC results in patients with parathyroid incidentaloma...
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Clinical Characteristics of the Hyalinizing Trabecular Tumor

Kim BC, Pak SJ, Cho JW, Kim WW, Lee Ym, Sung TY, Baek JH, Chung KW

Purpose: Hyalinizing trabecular tumors (HTTs) are rare tumors of the thyroid gland. They are benign and of follicular origin. However, they are difficult to diagnose and can be misdiagnosed as...
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Is antibiotic prophylaxis necessary after endoscopic ultrasound–guided fine-needle aspiration of pancreatic cysts?

Hakim S, Gjeorgjievski M, Khan Z, Cannon ME, Yu K, Patil P, DaVee RT, Guha S, Badillo R, Jamil L, Thosani N, Ramireddy S

Background/Aims: Current society guidelines recommend antibiotic prophylaxis for 3 to 5 days after endoscopic ultrasound–guided fine-needle aspiration (EUS-FNA) of pancreatic cystic lesions (PCLs). The overall quality of the evidence supporting...
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Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: its updated diagnostic criteria, preoperative cytologic diagnoses and impact on the risk of malignancy

Na HY, Park SY

Due to the extremely indolent behavior, a subset of noninvasive encapsulated follicular variant papillary thyroid carcinomas has been classified as “noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)” since...
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The application of high-throughput proteomics in cytopathology

Nikas IP, Ryu HS

High-throughput genomics and transcriptomics are often applied in routine pathology practice to facilitate cancer diagnosis, assess prognosis, and predict response to therapy. However, the proteins rather than nucleic acids are...
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Endoscopic Ultrasound-Based Evaluation of Pancreatic Cysts: New Invasive Modalities

Koo CS, Ho KY

Pancreatic cysts are a heterogenous group of lesions that can be differentiated into mucinous and non-mucinous cysts based on their malignant potential. Crosssectional imaging alone is inadequate to reliably distinguish...
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Diagnostic Performance of Core Needle Biopsy for Characterizing Thyroidectomy Bed Lesions

Jeong SY, Baek JH, Chung SR, Choi YJ, Song DE, Chung KW, Kim WW, Lee JH

Objective: Thyroidectomy bed lesions frequently show suspicious ultrasound (US) features after thyroid surgery. Fine-needle aspiration (FNA) may not provide definitive pathological information about the lesions. Although core-needle biopsy (CNB) has...
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Papillary and medullary thyroid carcinomas coexisting in the same lobe, first suspected based on fine-needle aspiration cytology: a case report

Koh HH, Oh YL

Because different types of thyroid malignancies have distinct embryological origins, coexisting tumors are rarely observed. We describe a coexisting papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC) first suspected...
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Comparison of diagnostic performances of slow-pull suction and standard suction in endoscopic ultrasound-guided fine needle biopsy for gastrointestinal subepithelial tumors

Lee JS, Cho CM, Kwon YH, Seo AN, Bae HI, Han MH

Background/Aims: Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) is integral to the diagnosis of gastrointestinal (GI) subepithelial tumors (SETs). The impact of different EUS-FNB tissue sampling techniques on specimen adequacy and diagnostic...
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Changes in Diagnostic Performance of Thyroid Cancer Screening before and after the Korean Thyroid Imaging Reporting and Data System Revision

Kim NH, Han JS, Bae WK, Kim JY, Lee K, Lee H, Lee KH, Jung SY, Lee H, Jeong HY, Kim YA, Sim S, Kang JW

Background: Since the era of “thyroid cancer epidemic,” many Korean academic societies discouraged the use of ultrasonography in healthy individuals and revised the Korean Thyroid Imaging Reporting and Data System...
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Do ACR TI-RADS scores demonstrate unique thyroid molecular profiles?

Xia R, Sun W, Yee J, Sheth S, Slywotzky C, Hodak S, Brandler TC

Purpose: The present study aimed to examine the molecular profiles of cytologically indeterminate thyroid nodules stratified by American College of Radiology Thyroid Imaging Reporting and Data System (TI-RADS) categories and...
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Establishment of Patient-Derived Pancreatic Cancer Organoids from Endoscopic Ultrasound-Guided Fine-Needle Aspiration Biopsies

Lee JH, Kim H, Lee SH, Ku JL, Chun JW, Seo HY, Kim SC, Paik WH, Ryu JK, Lee SK, Lowy AM, Kim YT

Background/Aims: Three-dimensional cultures of human pancreatic cancer tissue also known as “organoids” have largely been developed from surgical specimens. Given that most patients present with locally advanced and/or metastatic disease,...
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