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Role of 5'-CpG island hypermethylation of the FHIT gene in cervical carcinoma

Ki KD, Lee SK, Tong SY, Lee JM, Song DH, Chi SG

OBJECTIVE: The abnormal expression of fragile histidine triad (FHIT) gene has been frequently reported in a variety of epithelial malignancies including cervical carcinoma. Furthermore, in a recent study it was...
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Expression of p16, Rb and FHIT Proteins in Urothelial Carcinoma of the Urinary Bladder

Han SH, Lee JH, Kim SH, An J, Lee ES, Kim YS

  • KMID: 1163218
  • Korean J Pathol.
  • 2008 Oct;42(5):294-298.
BACKGROUND: The goal of this study was to investigate the expression of p16, retinoblastoma (Rb) and fragile histidine triad (FHIT) proteins in urothelial carcinomas of the urinary bladder, and to...
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Promoter hypermethylation and loss of heterozygosity of FHIT genes in squamous cell carcinoma of uterine cervix

Ko OJ, Choi CH, Kim TJ, Kim WY, Lee KM, Choi JJ, Lee JW, Kim BG, Lee JH, Bae DS

  • KMID: 2244565
  • Korean J Gynecol Oncol.
  • 2007 Jun;18(2):139-145.
OBJECTIVE: This study was to investigate the status of hypermethylation and loss of heterozygosity (LOH) in chromosome 3p tumor-suppressor gene for cervical carcinoma. METHODS: We examined the promoter methylation status...
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Clinicopathological Significance of FHIT Protein Expression in Cervical Adenocarcinoma

Lee TS, Suh DH, Kang SB

  • KMID: 2272872
  • Korean J Obstet Gynecol.
  • 2006 Aug;49(8):1690-1696.
OBJECTIVE: To investigate the expression of fragile histidine triad (FHIT) protein and the possible relationship between FHIT expression and clinicopathological indices in cervical adenocarcinoma. METHODS: FHIT protein expression was examined...
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The Aberrant Expression of FHIT Transcripts in Uterine Cervical Cancer using Laser-capture Microdissection

Choi SC, Kim BG, Bae DS, Moon HB

  • KMID: 2272681
  • Korean J Obstet Gynecol.
  • 2005 Sep;48(9):2140-2147.
OBJECTIVE: This study was performed to determine the exact pattern of FHIT expression of the cervical carcinoma cell per se by microdissection and to investigate the clinical significance of the...
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Expressions of p130Cas and FHIT, and Their Relationships with Prognostic Factors for Breast Carcinomas

Choi HJ, Jung JH, Yoo J, Kang SJ, Kang CS

  • KMID: 2275440
  • Korean J Pathol.
  • 2005 Feb;39(1):41-47.
BACKGROUND: BCAR1/p130Cas protein is the human homologue of rat p130Cas protein, and it is a docking protein involved in the intracellular signaling pathways. This protein also causes the proliferating human...
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Abnormal Fragile Histidine Triad (FHIT) Expression in Cervical Carcinomas

Tong SY, Lee SK, Ji SG

  • KMID: 2272360
  • Korean J Obstet Gynecol.
  • 2004 Jun;47(6):1093-1099.
OBJECTIVE: The fragile histidine triad (FHIT) gene is located at chromosome 3p14.2 and encompasses the common fragile site, FRA3B, which may contribute to chromosome breakage and rearrangement of cancer cells....
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Mechanism of FHIT-Induced Apoptosis in Lung Cancer Cell Lines

Yoo JS, Kim CH

BACKGROUND: The FHIT (fragile histidine triad) gene is a frequent target of deletions associated with abnormal RNA and protein expression in lung cancer. Previous studies have shown FHIT gene transfer...
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Expression of FHIT and p21 in Gastric Adenocarcinoma

Choi HJ, Kim BK, Yoo J, Kang SJ, Kang CS

  • KMID: 2275524
  • Korean J Pathol.
  • 2004 Feb;38(1):35-41.
BACKGROUND: The fragile histidine triad (FHIT) gene, located on the human chromosome 3p14.2, is frequently inactivated by its deletion in a number of human tumors, including gastric carcinomas. Its protein...
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The Pattern of Fhit and p53 Expression in Cervical Intraepithelial Neoplasm and Invasive Cervical Cancer

Joo SH, Myong NH, Park JW

  • KMID: 2272474
  • Korean J Obstet Gynecol.
  • 2004 Dec;47(12):2403-2048.
OBJECTIVE: To evaluate Fragile histidine triad (Fhit) and p53 expression pattern in cervical intraepithelial neoplasm (CIN) and invasive cervical cancer, and to verify the correlation between the loss of Fhit...
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Loss of FHIT Expression in Non-Small Cell Lung Cancer: The Clinical Significance and Effects on Apoptosis and Cell Proliferation Cycle

Kim HR, Yang SH, Jeong ET

BACKGROUND: 3p deletion has been shown to be the most frequently occurring change in lung cancers, suggesting the presence of a tumor suppressor gene in this region. Recent attention has...
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Abnormal Fragile Histidine Triad Gene Expression in Gastric Cancer

Lee MS, Kim TY, Cho GS, Chae MK, Kim SY, Baek MJ, Lee SH, Park KK, Kim CH, Song OP, Cho MS

  • KMID: 2372713
  • J Korean Gastric Cancer Assoc.
  • 2003 Mar;3(1):26-32.
PURPOSE: Genomic alterations and abnormal expression of the fragile histidine triad (FHIT) gene in gastric cancer were examined to determine whether the FHIT gene is actually a frequent target for...
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Sequence Analyses of Aberrant FHIT Transcripts in Gastric Cancer Cell Lines

Lee SH, Kim HS

  • KMID: 1066038
  • Korean J Gastroenterol.
  • 2003 Dec;42(6):476-483.
BACKGROUND/AIMS: The fragile histidine triad (FHIT) gene located at chromosome 3p14.2, is a candidate tumor suppressor gene often involved in various tumors. Homozygous deletions, lack or reduced expression of...
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Loss of Fhit Expression in Cervical Intraepithelial lesion and Invasive Cervical Carcinoma

Lee BG, Lee JS, Lee DH, Kim MJ, Lee YG, Park YK, Lee DJ, Lee SH

  • KMID: 2262622
  • Korean J Obstet Gynecol.
  • 2002 Feb;45(2):226-233.
OBJECTIVE: The author evaluated the relationship between the loss of Fhit and prognostic factors of invasive cervical carcinomas. METHODS: The formalin prepared tissue specimens of 64 CINs and 27 invasive...
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Characterization of aberrant FHIT transcripts in gastric adenocarcinomas

Lee SH, Kim CJ, Park HK, Koh JW, Cho MH, Baek MJ, Lee MS

  • KMID: 938875
  • Exp Mol Med.
  • 2001 Sep;33(3):124-130.
Aberrant transcripts of FHIT (fragile histidine triad) have been reported in several types of primary tumors and cell lines, including gastric carcinoma. The role of these aberrant transcripts in tumorigenesis...
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Study of Microsatellite Alterations of 3p and 11q Chromosomes in Uterine Cervical Adenocarcinoma

Lee ES, Jeong HJ, Kim HJ, Kim I

  • KMID: 2275644
  • Korean J Pathol.
  • 2001 Apr;35(2):137-143.
BACKGROUND: Uterine cervical cancer is the most prevalent cancer in Korean women, and the incidence of adenocarcinoma has been increasing. Loss of heterozygosity (LOH) analysis is used to identify regions...
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Altered Fhit Expression and Its Relationship with p53 Overexpression in Non-small Cell Lung Cancers

Myong NH, Yoon SJ

  • KMID: 2141019
  • Korean J Pathol.
  • 2001 Feb;35(1):1-6.
BACKGROUND: FHIT (Fragile histidine triad), the tumor suppressor gene at 3p14.2, encompasses the FRA3B fragile site and is a common target of deletions in primary human epithelial cancers, including those...
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Loss of Heterozygosity on Chromosome 3p, 9p, 17p in Oral & Oropharyngeal Squamous Cell Carcinoma

Lee SH, Kim MS, Sun DI, Song CJ, Cho SH

  • KMID: 2274729
  • Korean J Otolaryngol-Head Neck Surg.
  • 2000 Jul;43(7):746-750.
BACKGROUND AND OBJECTIVES: Patients of oral and oropharyngeal squamous cell carcinoma in the comparable stage have diverse clinical courses and responses to similar treatment. Understanding the genetic alterations that occur...
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Expression of FHIT protein and allelic deletion at FHIT locus in primary cervical carcinoma tissues

Kim SY, Seong YS

  • KMID: 2261902
  • Korean J Obstet Gynecol.
  • 2000 Apr;43(4):694-703.
Allelic deletions involving the short arm of chromosome 3(3p13-21.1) have been observed frequently in cervical carcinomas. Recently the fragile histidine triad(FHIT) gene was cloned and mapped to this chromosomal region(3p14.2). From various...
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Genetic alteration of tumor suppressor gene and microsatellite in nonsmall cell lung cancer

Shin TR, Hong YS, Kim JG, Chang JH

BACKGROUND: Lung carcinogenesis is a multistage process involving alterations in multiple genes and diverse pathway. Mutational activation of oncogenes and inactivation of tumor suppressor genes, and subsequent increased genetic instability...
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