- Etoposide Induces Mitochondrial Dysfunction and Cellular Senescence in Primary Cultured Rat Astrocytes
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Bang M, Kim DG, Gonzales E, Kwon KJ, Shin CY
- KMID: 2462880
- Biomol Ther.
- 2019 Nov;27(6):530-539.
- doi: 10.4062/biomolther.2019.151
Brain aging is an inevitable process characterized by structural and functional changes and is a major risk factor for neurodegenerative diseases. Most brain aging studies are focused on neurons and... -
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- Effect of Relaxin Expression from an Alginate Gel-Encapsulated Adenovirus on Scar Remodeling in a Pig Model
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Yun IS, Kang E, Ahn HM, Kim YO, Rah DK, Roh TS, Lee WJ, Yun CO
- KMID: 2457481
- Yonsei Med J.
- 2019 Sep;60(9):854-863.
- doi: 10.3349/ymj.2019.60.9.854
PURPOSE: Relaxin (RLX) is a transforming growth factor-β1 (TGF-β1) antagonist that is believed to function as a potent collagen re-arranger and a major suppressor of extracellular matrix components. Adenoviruses (Ads)... -
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- Direct-acting antivirals-based therapy decreases hepatic fibrosis serum biomarker microfibrillar-associated protein 4 in hepatitis C patients
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Mölleken , Ahrens M, Schlosser , Dietz J, Eisenacher M, Meyer HE, Schmiegel , Holmskov U, Sarrazin C, Sorensen G, Sitek B, Bracht T
- KMID: 2447250
- Clin Mol Hepatol.
- 2019 Mar;25(1):42-51.
- doi: 10.3350/cmh.2018.0029
BACKGROUND/AIMS: An estimated 80 million people worldwide are infected with viremic hepatitis C virus (HCV). Even after eradication of HCV with direct acting antivirals (DAAs), hepatic fibrosis remains a risk... -
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- Noncoding RNAs as therapeutic targets in early stage diabetic kidney disease
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Kato M
- KMID: 2447159
- Kidney Res Clin Pract.
- 2018 Sep;37(3):197-209.
- doi: 10.23876/j.krcp.2018.37.3.197
Diabetic kidney disease (DKD) is a major renal complication of diabetes that leads to renal dysfunction and end-stage renal disease (ESRD). Major features of DKD include accumulation of extracellular matrix... -
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- Silencing Histone Deacetylase 7 Alleviates Transforming Growth Factor-β1-Induced Profibrotic Responses in Fibroblasts Derived from Peyronie's Plaque
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Kang DH, Yin GN, Choi MJ, Song KM, Ghatak K, Minh NN, Kwon MH, Seong DH, Ryu JK, Suh JK
- KMID: 2419312
- World J Mens Health.
- 2018 May;36(2):139-146.
- doi: 10.5534/wjmh.170005
PURPOSE: Epigenetic modifications, such as histone acetylation/deacetylation and DNA methylation, play a crucial role in the pathogenesis of inflammatory disorders and fibrotic diseases. The aim of this study was to... -
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- Effects of Remifentanil Preconditioning Attenuating Oxidative Stress in Human Dermal Fibroblast
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Yoon JY, Park CG, Park BS, Kim EJ, Byeon GJ, Yoon JU
- KMID: 2377343
- Tissue Eng Regen Med.
- 2017 Apr;14(2):133-141.
- doi: 10.1007/s13770-017-0030-9
Human dermal fibroblast is essential in wound healing of the skin through the synthesis of extracellular matrix proteins. With respect to oxidative stress, the effects of remifentanil on human dermal... -
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- Role of TGFBIp in Wound Healing and Mucin Expression in Corneal Epithelial Cells
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Maeng YS, Lee GH, Lee B, Choi SI, Kim TI, Kim EK
- KMID: 2427133
- Yonsei Med J.
- 2017 Mar;58(2):423-431.
- doi: 10.3349/ymj.2017.58.2.423
PURPOSE: Transforming growth factor-β-induced protein (TGFBIp) is highly expressed in the cornea, and mutant TGFBIp induces corneal diseases. However, the function of TGFBIp in cornea epithelium is not fully investigated.... -
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- Skin Pigmentation and Pigmentary Disorders: Focus on Epidermal/Dermal Cross-Talk
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Bastonini , Kovacs D, Picardo M
- KMID: 2164634
- Ann Dermatol.
- 2016 Jun;28(3):279-289.
- doi: 10.5021/ad.2016.28.3.279
Variation in human skin and hair color is the most notable aspect of human variability and several studies in evolution, genetics and developmental biology contributed to explain the mechanisms underlying... -
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- Identification of a Fibrillin-1 Gene Mutation in a Monozygotic Twin Presenting with Bilateral Juvenile-onset Ectopia Lentis
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Yum HR, Kim SE, Shin SY, Park SH
- KMID: 2360145
- Korean J Ophthalmol.
- 2015 Feb;29(1):77-78.
- doi: 10.3341/kjo.2015.29.1.77
No abstract available. -
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- Elevated Cellular Retinoic Acid Binding Protein-I in Cerebrospinal Fluid of Patients with Hemorrhagic Cerebrovascular Diseases : Preliminary Study
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Jeon JP, Cho WS, Kang HS, Kim JE, Kim SK, Oh CW
- KMID: 2191188
- J Korean Neurosurg Soc.
- 2015 Feb;57(2):88-93.
- doi: 10.3340/jkns.2015.57.2.88
OBJECTIVE: Elevated cellular retinoic acid binding protein-I (CRABP-I) is thought to be related to the abnormal proliferation and migration of smooth muscle cells (SMCs). Accordingly, a higher CRABP-I level could... -
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- Effects of Topical Intranasal Doxycycline Treatment in the Rat Allergic Rhinitis Model
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Avincsal M, Ozbal S, Ikiz AO, Pekcetin C, Guneri EA
- KMID: 2278383
- Clin Exp Otorhinolaryngol.
- 2014 Jun;7(2):106-111.
OBJECTIVES: Allergic rhinitis (AR) is a chronic upper respiratory tract disease that inflames the mucous membranes of the nose and occurs when circulating inflammatory cells including eosinophils and basophils migrate... -
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- A Korean Patient with Lattice Corneal Dystrophy Type IV with Leu527Arg Mutation in the TGFBI Gene
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Kim J, Lee KA, Kim EK, Lee HK
- KMID: 1792097
- Korean J Ophthalmol.
- 2014 Feb;28(1):83-85.
- doi: 10.3341/kjo.2014.28.1.83
An 87-year-old woman visited our clinic for a scheduled cataract surgery. At the time of preoperative evaluation, slit lamp examination showed lattice-shaped and granular deposits with asymmetrical patterns in the... -
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- Roles of Matrix Metalloproteinases and Their Targets in Epileptogenesis and Seizures
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Mizoguchi , Yamada K
- KMID: 2171153
- Clin Psychopharmacol Neurosci.
- 2013 Aug;11(2):45-52.
Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) remodel the pericellular environment by regulating the cleavage of extracellular matrix proteins, cell surface components, neurotransmitter receptors, and growth factors, which... -
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- A Trial of Screening of Genes Involved in Odontoblasts Differentiation from Human Dental Pulp Stem Cells
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Park YK, Kim HJ
- KMID: 1431130
- Int J Oral Biol.
- 2012 Dec;37(4):167-173.
This study investigated the genes involved in the differentiation of odontoblasts derived from human dental pulp stem cells (hDPSCs). hDPSCs isolated from human tooth pulp were validated by fluorescence activated... -
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- Effect of Combined Sex Hormone Replacement on Bone/Cartilage Turnover in a Murine Model of Osteoarthritis
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Yang JH, Kim JH, Lim DS, Oh KJ
- KMID: 1392987
- Clin Orthop Surg.
- 2012 Sep;4(3):234-241.
- doi: 10.4055/cios.2012.4.3.234
BACKGROUND: Estrogens act on estrogen receptors distributed in articular cartilages, synovial membrane, and ligaments, which are thought to be related with degenerative changes. Meanwhile, progesterone is known to have a... -
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- Cysteinyl Cathepsins: Multifunctional Enzymes in Cardiovascular Disease
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Li X, Liu Z, Cheng Z, Cheng X
- KMID: 2172207
- Chonnam Med J.
- 2012 Aug;48(2):77-85.
- doi: 10.4068/cmj.2012.48.2.77
Until recently, the role of lysosomal cysteine protease cathepsins in intracellular protein degradation was believed to be mainly restricted to scavenging. However, recent studies have revealed nontraditional roles for cysteine... -
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- TGF-beta-activated kinase-1: New insights into the mechanism of TGF-beta signaling and kidney disease
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Kim SI, Choi ME
- KMID: 1441574
- Kidney Res Clin Pract.
- 2012 Jun;31(2):94-105.
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates a wide variety of cellular functions, including cell growth, cellular differentiation, apoptosis, and wound healing. TGF-beta1, the prototype member of... -
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- Engineering Biomaterials for Feeder-Free Maintenance of Human Pluripotent Stem Cells
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Yang K, Lee J, Cho SW
- KMID: 1426150
- Int J Stem Cells.
- 2012 May;5(1):1-5.
Human pluripotent stem cells (hPSCs) are capable of differentiating into any type of somatic cell, a characteristic that imparts significant therapeutic potential. Human embryonic stem cells and induced pluripotent stem... -
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- COMP-Angiopoietin-1 Stimulates Synovial Proliferation but Suppresses Osteoclast by Enhancing Angiogenesis and Osteoblast Maturation in Collagen-Induced Arthritis
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Jeong YG, Kim HO, Lim HS, Hah YS, Cho HY, Yu J, Park BH, Koh GY, Lee SI
- KMID: 2223105
- J Rheum Dis.
- 2012 Apr;19(2):82-90.
- doi: 10.4078/jrd.2012.19.2.82
OBJECTIVE: Angiopoietin-1 (Ang1) is a potent angiogenic factor that can increase synovial angiogenesis and also enhance osteoblast maturation and bone formation. However, its role in rheumatoid arthritis (RA) has not... -
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- Therapeutic Effect of a Recombinant betaig-h3 Fragment-RGD Peptide for Chronic Inflammatory Arthritis
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Jang JA, Kang JH, Sa KH, Han SW, Seo JS, Kim KH, Nam EJ, Kim IS, Kang YM
- KMID: 2223104
- J Rheum Dis.
- 2012 Apr;19(2):73-81.
- doi: 10.4078/jrd.2012.19.2.73
OBJECTIVE: betaig-h3 is a 68kDa extracellular matrix protein which is overexpressed in synovial tissues of rheumatoid arthritis (RA). Previous results proved that betaig-h3 fragments are relevant to adhesion and migration... -
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