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The role of the exocyst in renal ciliogenesis, cystogenesis, tubulogenesis, and development

Lipschutz

The exocyst is a highly conserved eight-subunit protein complex (EXOC1–8) involved in the targeting and docking of exocytic vesicles translocating from the trans-Golgi network to various sites in renal cells....
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Regulation of Mucin Exocytosis in Airway Secretory Cells

Kim JH

Mucin secretion in the airway epithelium acts as an essential barrier process that protects the upper respiratory tract from inhaled particles, environmental pathogens and toxicants. However, dysregulated mucin secretion contributes...
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Formation of Airway Mucus; Synthesis, Exocytosis and Dilution of Gel-Forming Mucins

  • KMID: 1969528
  • Korean J Asthma Allergy Clin Immunol.
  • 2012 Jun;32(2):73-80.
The lungs are highly defensive to environmental challenges thanks to the airway mucus layer, not only as a pool of antimicrobial and antioxidant contents but also as an important part...
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Intracellular Ca2+ Mobilization and Beta-hexosaminidase Release Are Not Influenced by 60 Hz-electromagnetic Fields (EMF) in RBL 2H3 Cells

Hwang YH, Song HS, Kim HR, Ko MS, Jeong JM, Kim YH, Ryu JS, Sohn UD, Gimm YM, Myung SH, Sim SS

The effects of extremely low frequency electromagnetic fields (EMF) on intracellular Ca2+ mobilization and cellular function in RBL 2H3 cells were investigated. Exposure to EMF (60 Hz, 0.1 or 1...
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Topographical Propagation of alpha-synuclein Pathology in Parkinson's Disease: Phenomenology and Hypothetical Mechanism

Hyun M, Lee SJ

Parkinson's disease is an age-related, slowly progressing neurodegenerative disorder characterized by abnormal deposition of aggregated alpha-synuclein in neuronal cell bodies (Lewy bodies) and neurites (Lewy neurites), as well as in...
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Screening of Low Molecular Metabolite, FS390 as an Inhibitor of Neurotransmitter Release from PC12 Cells

Chung YT, Kim HJ, Lee YS

  • KMID: 1937820
  • Korean J Anat.
  • 2006 Apr;39(2):91-102.
We established an in vitro experimental system using the following procedure. We first introduced tritium-labeled norepinephrine ([3H]-NE) into PC12 cells. The [3H]-NE incorporated-PC12 cells were stimulated by a high concentration...
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Effect about Neurite Extension of FS390, an Inhibitor of Exocytosis in Rat Hippocampal Neurons and PC12 Cells

Choi MK, Chon GH, Lee YS

  • KMID: 1937819
  • Korean J Anat.
  • 2006 Apr;39(2):81-90.
FS390, a novel microbial metabolite from Streptomyces spp. was identified as a small molecular substance and shown a inhibition activities for the release of neurotransmitter from rat hippocampal neuron and...
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Expression of Ca2+-dependent Synaptotagmin Isoforms in Mouse and Rat Parotid Acinar Cells

Jo H, Byun HM, Kim JH, Kim MS, Kim SH, Hong JH, Seo JT, Lee SI, Shin DM, Son HK

Synaptotagmin is a Ca2+ sensing protein, which triggers a fusion of synaptic vesicles in neuronal transmission. Little is known regarding the expression of Ca2+ - dependent synaptotagmin isoforms and their...
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Early phase of amyloid beta42-induced cytotoxicity in neuronal cells is associated with vacuole formation and enhancement of exocytosis

Liu ML, Hong ST

  • KMID: 1116201
  • Exp Mol Med.
  • 2005 Dec;37(6):559-566.
Amyloid beta (Abeta) neurotoxicity is believed to play a critical role in the pathogenesis of Alzheimer's disease (AD) mainly because of its deposition in AD brain and its neuronal toxicity....
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Control of the priming and triggering phases of exocytosis in the pancreatic acinar cell

Padfield P

No abstract available.
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Vesicular transport as a new paradigm in short-term regulation of transepithelial transport

Park CS, Leem CH, Jang YJ, Shim YH

The vectorial transepithelial transport of water and electrolytes in the renal epithelium is achieved by the polarized distribution of various transport proteins in the apical and basolateral membrane. The short-term...
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Vesicular transport with emphasis on exocytosis

Park CS, Lee PH

The eukaryotic cell is compartmentalized by a series of vesicular organelles which constitute the endocytic and exocytic transport pathways. Each vesicular compartment has distinct sets of membrane proteins, structures and...
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