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Effects of etomidate use in ICU patients on ventilator therapy: a study of 12,526 patients in an open database from a single center

Park HY, Lee Y, Lim CY, Kim M, Park J, Lee T

Background: There is a debate regarding the safety of etomidate. We evaluated the effects of etomidate on mortality in a large cohort of critical care patients. Methods: This retrospective matched-cohort study...
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Efficacy and Safety of Etomidate in Comparison with Propofol or Midazolam as Sedative for Upper Gastrointestinal Endoscopy

Kim JH, Byun S, Choi YJ, Kwon HJ, Jung K, Kim SE, Park MI, Moon W, Park SJ

Background/Aims: In this study, we compared the efficacy and safety of etomidate with those of propofol or midazolam for the maintenance of sedation during endoscopy. Methods: The study enrolled patients who...
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Easy sedation anesthesia guide for non-anesthetic medical personnel

Min TJ

Currently, sedation anesthesia is increasingly used in many medical fields, from gastroscopy to medical imaging. The demand for sedation anesthesia is expected to increase gradually with increasing number of day...
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Using Etomidate and Midazolam for Screening Colonoscopies Results in More Stable Hemodynamic Responses in Patients of All Ages

Lee JM, Min G, Keum B, Lee JM, Kim SH, Choi HS, Kim ES, Seo YS, Jeen YT, Chun HJ, Lee HS, Um SH, Kim CD

BACKGROUND/AIMS: Recent studies have demonstrated that etomidate is a safe sedative drug with noninferior sedative effects. In our recent study, we revealed that etomidate/midazolam was more hemodynamically stable than propofol/midazolam...
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Comparison of priming versus slow injection for reducing etomidate-induced myoclonus: a randomized controlled study

Mullick P, Talwar V, Aggarwal S, Prakash S, Pawar M

BACKGROUND: Etomidate injection is often associated with myoclonus. Etomidate injection technique influences the incidence of myoclonus. This study was designed to clarify which of the two injection techniques—slow injection or...
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The effects of etomidate and midazolam on adipose tissue-derived mesenchymal stem cell proliferation

Park H, Ryu K, Kim YH, Choi WJ, Ko D

BACKGROUND: Stem cell therapy using adipose tissue-derived mesenchymal stem cells (ADSCs), which are capable of multipotent differentiation, is currently being investigated in the field of tissue regeneration and the treatment...
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Comparison of etomidate and propofol on intubating conditions and the onset time associated with cisatracurium administration

Ko YK, Kim YH, Park SI, Chung WS, Noh C, Lee JU

BACKGROUND: This study compared intubating conditions and the onset time associated with administration of cisatracurium, a nondepolarizing neuromuscular blocker with a relatively slow onset, according to prior injection of one...
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Comparison of cardiovascular responses measured with a Vigileo-FloTrac device after propofol or etomidate with remifentanil for the induction of general anesthesia in geriatric patients

Chung WS, Kim YH, Kim JK, Kim BJ, Lee J

  • KMID: 1908525
  • Anesth Pain Med.
  • 2014 Jul;9(3):179-184.
BACKGROUND: Remifentanil efficiently blunts the stress response during endotracheal intubation, but also causes hypotension, especially in geriatric patients. Hence, this study was designed to compare the hemodynamic changes during the...
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Comparison of effects of fentanyl and remifentanil on hemodynamic response to endotracheal intubation and myoclonus in elderly patients with etomidate induction

Ko BJ, Oh JN, Lee JH, Choi SR, Lee SC, Chung CJ

BACKGROUND: Etomidate has a stable hemodynamic profile after induction, but hypertension and tachycardia are frequent after intubation as well as myoclonus. We compared the effects of fentanyl and remifentanil on...
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Effects of etomidate on bispectral index scale and spectral entropy during induction of anesthesia by means of the raw electroencephalographic and electromyographic characteristics

Kim HM, Shin SW, Yoon JY, Lee HJ, Kim KH, Baik SW

BACKGROUND: Etomidate frequently induces myoclonus, so it may affect electromyographics (EMG). And EMG commonly has an effect on the bispectral index scale (BIS) and spectral entropy. This study was performed...
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The proper effect site concentration of remifentanil for prevention of myoclonus after etomidate injection

Ri HS, Shin SW, Kim TK, Baik SW, Yoon JU, Byeon GJ

BACKGROUND: Etomidate frequently induces myoclonus when administered intravenously with bolus injection during anesthetic induction. This can be bothersome for the anesthesiologist. The dose of remifentanil appropriate for preventing myoclonus without...
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Comparative Study of Brain Protection Effect between Thiopental and Etomidate Using Bispectral Index during Temporary Arterial Occlusion

Kim TK, Park IS

OBJECTIVE: This study was conducted to compare the effect of etomidate with that of thiopental on brain protection during temporary vessel occlusion, which was measured by burst suppression rate (BSR)...
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Anesthetic efficacy of etomidate, propofol and thiopental sodium during electroconvulsive therapy

Jun GW, Yang HS, Lee YK, Seo HJ

  • KMID: 2169190
  • Anesth Pain Med.
  • 2011 Jan;6(1):32-36.
BACKGROUND: Electroconvulsive therapy (ECT) is effective for major psychosis and affective disorder. The ideal anesthetics for ECT provide rapid induction and recovery, and they attenuate the adverse effects of ECT....
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Effects of propofol and etomidate on hydrogen peroxide-induced oxidative damage in hepatocyte

Lee EH, Shin JW, Yoon SK, Son HJ, Lee JY, Ku SW, Kim JU, Lee YM

BACKGROUND: The present investigation was undertaken to evaluate the protective effect of propofol and etomidate against hydrogen peroxide (H2O2) induced oxidative damage in human hepatic SNU761 cells by measuring lactate...
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The effects of etomidate on the contraction of pregnant rat uterine smooth muscle

Chung CD, An TH, Jung KT, Lee TH

BACKGROUND: It has been reported that etomidate has the relaxant effects on vascular, tracheal, and non-pregnant uterine smooth muscle in vitro. The purpose of this study was to investigate the...
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The effect of remifentanil for reducing myoclonus during induction of anesthesia with etomidate

Lee SW, Gill HJ, Park SC, Kim JY, Kim JH, Lee JY, Yang HJ, Kim MK

BACKGROUND: Myoclonic movement is a common problem during induction of anesthesia with etomidate. We investigated the influences of pretreatment with remifentanil on etomidate induced myoclonus. METHODS: Ninety ASA class I patients...
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The optimal dosage of alfentanil pretreatment for prevention of myoclonus after injection of etomidate

Cho SY, Jeon WJ, Nam YM, Yeom JH, Kim KH

BACKGROUND: Myoclonus is a common problem during induction of general anesthesia with etomidate. We investigated the optimal dosage of alfentanil pretreatment for prevention of myoclonus after injection of etomidate. METHODS: In...
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The effect of injection rate on etomidate-induced myoclonus

Do SH, Han SH, Park SH, Kim JH, Hwang JY, Son IS, Kim MS

BACKGROUND: Etomidate frequently causes myoclonus. Since the myoclonus is caused by a transient disequilibrium due to etomidate exposure in the CNS, we hypothesized that a slow rate of injection of...
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Effect of propofol and etomidate in respiratory epithelial cell infected with rhinovirus

Lee YK, Son HJ, Ku SW, Jang YJ, Lee HJ, Kim JU

BACKGROUND: There have been no previous studies on the effect of anesthetic agents on rhinovirus (RV) infection, which is the most common pathogen of the common cold in human airway...
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The effect of fentanyl pretreatment on myoclonus during induction of anesthesia with etomidate in elderly patients

Lee JH, Lee JH, Chin YJ, Lee SI, Chung CJ, Lee SC, Choi SR

BACKGROUND: Etomidate is frequently used as an induction agent in the elderly patients. This study was done to determine whether etomidate-based induction can provide hemodynamic stability and fentanyl decreases the...
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