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Inhibition of the Human Ether-a-go-go-related Gene (HERG) K+ Channels by Lindera erythrocarpa

Hong HK, Yoon WJ, Kim YH, Yoo ES, Jo SH

Lindera erythrocarpa Makino (Lauraceae) is used as a traditional medicine for analgesic, antidote, and antibacterial purposes and shows anti-tumor activity. We studied the effects of Lindera erythrocarpa on the human...
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In vivo targeting of ERGpotassiumchannels inmice and dogs by a positron-emitting analogue of fluoroclofilium

Kim SW, Yang SD, Ahn BJ, Park JH, Lee DS, Gessner G, Heinemann , Herdering , Yu KH

  • KMID: 1093461
  • Exp Mol Med.
  • 2005 Aug;37(4):269-275.
The antiarrhythmic clofilium is an efficient blocker of hERG1 potassium channels that are strongly expressed in the heart. Therefore, derivatives of clofilium that emit positrons might be useful tools for...
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