- Ethacrynic Acid Inhibits Sphingosylphosphorylcholine-Induced Keratin 8 Phosphorylation and Reorganization via Transglutaminase-2 Inhibition
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Byun HJ, Kang KJ, Park MK, Lee HJ, Kang JH, Lee EJ, Kim YR, Kim HJ, Kim YW, Jung KC, Kim SY, Lee CH
- KMID: 2048303
- Biomol Ther.
- 2013 Sep;21(5):338-342.
Sphingosylphosphorylcholine (SPC) is significantly increased in the malicious ascites of tumor patients and induces perinuclear reorganization of keratin 8 (K8) filaments in PANC-1 cells. The reorganization contributes to the viscoelasticity... -
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- Correlation between Dose of Ethacrynic Acid and Weight of Cat in the Cat Deafening Procedure
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Jang JH, Lee HS, Kim HY, Lee JH, Chang SO, Oh SH, Park MH
- KMID: 2277169
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2010 Dec;53(12):749-754.
- doi: 10.3342/kjorl-hns.2010.53.12.749
BACKGROUND AND OBJECTIVES: Co-administration of kanamycin (KM) with the loop diuretic ethacrynic acid (EA) has been known to produce a rapid and profound hearing loss in adult animals. The objective... -
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- Effect of Growth Factors on Hearing Restoration in Deafened Animal Model
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Kim JH, Park SN, Yeo SW, Kim YH, Jin SY, Kim JH, Cho SJ, Kim JH, Choi MY, Park KH
- KMID: 2276966
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2008 Dec;51(12):1093-1098.
BACKGROUND AND OBJECTIVES: Sensorineural hearing loss is caused by ototoxic drugs, radiation therapy, noise exposure and trauma, etc. They make irreversible changes in cochlear hair cells and degeneration of spiral... -
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- Proper Use of Diuretics
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Choi KH
- KMID: 2183616
- J Korean Med Assoc.
- 2005 Nov;48(11):1121-1127.
- doi: 10.5124/jkma.2005.48.11.1121
Diuretics are among the most commonly used drugs. They primarily block active reabsorption of sodium at different sites in the nephron, thereby increasing urinary losses of NaCl and H2O. This... -
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