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Progesterone Receptor Expression as a Prognostic Factor in Luminal B Breast Cancer

Lim S, Lee Y, Kim J, Cho H, Yang K, Park K, Kim J, Sin Y, Seo Y, Gwak G

Purpose: The luminal subtype of breast cancer has heterogeneous biological characteristics with respect to the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor-2 (HER2), and Ki-67....
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Comparative Morphological Study on Parotid and Submandibular Salivary Glands in Ovariectomized Rats

Jeong MJ, Lee MH, Lim DS, Jeong M, Jeong SJ

Background: Estrogen deficiency affects the structure and function of the salivary glands in women, leading to a decrease in salivary secretion and a change in the composition of saliva. Previous...
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Osteoporotic Fractures among Selective Estrogen Receptor Modulator Users in South Korea: Analysis Using National Claims Database

Park JW, Lee YK, Choi Y, Ha YC

Background: We evaluated (1) compliance with selective estrogen receptor modulator (SERM) use in postmenopausal women; and (2) the risk of osteoporotic fractures according to compliance and other patient characteristics. Methods: National...
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The Efficacy of Herbal Supplement Danggui Buxue Tang for Relieving Menopausal Symptoms

Wong EL, Cheung AW, Haines C, Wang C, Wong CK, Tsim KW, Cheng WK, Leung PC

Objectives: This study aimed to further explore the efficacy and safety of Danggui Buxue Tang (DBT), a simple herbal formula, for improving the quality of life of women suffering from...
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Estrogen Receptor β Expression and Its Clinical Implication in Breast Cancers: Favorable or Unfavorable?

Choi Y

There are two estrogen receptor (ER) genes (ESR1/ERα and ESR2/ERβ) in humans. Of those.ERβ, the second ER isotype identified in 1996, is differentially expressed in different phenotypes and molecular subtypes...
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Determination of the Estrogen Receptor Status of Leptomeningeal Metastasis in Patients with Metastatic Breast Cancer Using [ 18 F]-FES PET/CT: a Case Report

Ryu J, Jeong JH, Moon DH, Lee DY

Accurate determination of the hormone receptor status in patients with breast cancer is necessary to provide better palliative treatment because of the frequent discordant status of hormone receptors between primary...
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Knockdown of vps54 aggravates tamoxifen-induced cytotoxicity in fission yeast

Lee S, Nam M, Lee AR, Baek ST, Kim MJ, Kim JS, Kong AH, Lee M, Lee SJ, Kim SY, Kim DU, Hoe KL

Tamoxifen (TAM) is an anticancer drug used to treat estrogen receptor (ER)‒positive breast cancer. However, its ER-independent cytotoxic and antifungal activities have prompted debates on its mechanism of action. To...
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Exercise Training Attenuates Ovariectomy-Induced Alterations in Skeletal Muscle Remodeling, Apoptotic Signaling, and Atrophy Signaling in Rat Skeletal Muscle

Cho EJ, Choi Y, Kim J, Bae JH, Cho J, Park DH, Kang JH, Yoon JH, Park E, Seo DY, Lee S, Kwak HB

Purpose: The effects of aerobic exercise training on soleus muscle morphology, mitochondria-mediated apoptotic signaling, and atrophy/hypertrophy signaling in ovariectomized rat skeletal muscle were investigated. Methods: Female Sprague-Dawley rats were divided into...
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Expression of Estrogen and Progesterone Receptors in Papillary Thyroid Carcinoma in Korea

Ahn HY, Song RY, Ahn HS, Kim HS

Purpose The aim of this study was to examine the rate of expression of estrogen receptor α (ERα) and β1 (ERβ1), progesterone receptor (PR), and rate of overexpression of epidermal...
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Gender Difference of Gut Microbiota in Liver Diseases

Suk KT

Although sexual difference medicine is a relatively new concept, it is currently an important research area because different treatments may be required according to gender. Gender-related differences in the epidemiology,...
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Incidence and Risk of Venous Thromboembolism in Bisphosphonates and Selective Estrogen Receptor Modulators Treatment in Korea

Park SY, Kim SH, Kim TY, Lee YK, Ha YC, Jang S, Ahn SH, Kim HY

Background: Selective estrogen receptor modulators (SERMs) were associated with an increased risk of venous thromboembolism (VTE) due to the estrogen effect. In this study, we investigated the effect of SERMs...
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Optimization of adipogenic differentiation conditions for canine adipose-derived stem cells

Kim JY, Park EJ, Kim SM, Lee HJ

Background: Canine adipose-derived stem cells (cADSCs) exhibit various differentiation properties and are isolated from the canine subcutaneous fat. Although cADSCs are valuable as tools for research on adipogenic differentiation, studies...
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Comparison of Bone Mineral Density and Markers of Bone Turnover in Osteoporotic Women after 6-Month Treatment with Alendronate or Bazedoxifene: A Randomized Controlled Trial

Han HS, Cho SH, Park MS, Sung KH, Lee KM

Background: In a randomized controlled trial, we compared the bone mineral densities (BMDs) and blood markers of bone turnover during short-term treatment of osteoporotic women with bisphosphonate alendronate or bazedoxifene,...
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Estrogen modulates epithelial progenitor cells in rat vagina

Chung HS, Lee HS, Park K

Purpose: The expression of epithelial progenitor cells (EPCs) in rat vagina was recently reported. The aims were to investigate the effects of estrogen on vaginal EPCs in the oophorectomized female...
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The Effects of Sex and Estrogen on Radiographic Progression of Ankylosing Spondylitis in Korean Patients

Jeong H, Bae EK, Hwang J, Park EJ, Lee J, Jeon CH, Koh EM, Cha HS

Objective. Ankylosing spondylitis (AS) is a chronic inflammatory disease with obvious male preponderance. Males show more severe radiographic manifestations compared with females. This study aimed to evaluate the effects of...
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Clinical Outcomes Following Letrozole Treatment according to Estrogen Receptor Expression in Postmenopausal Women: LETTER Study (KBCSG-006)

Ahn SG, Nam SJ, Ahn SH, Jung Y, Park HK, Lee SJ, Kang SS, Han W, Park KH, Park YL, Lee J, Youn HJ, Kim JH, Yoo Y, Song JY, Ko BK, Gwak G, Chung MS, Kim SY, Cho SH, Kim D, Chang MC, Moon BI, Kim LS, Kim SJ, Park MH, Kim TH, Cho J, Lim CW, Bae YT, Gong G, Bae YK, Lee A, Jeong J

Purpose: In this trial, we investigated the efficacy and safety of adjuvant letrozole for hormone receptor (HR)-positive breast cancer. Here, we report the clinical outcome in postmenopausal women with HR-positive...
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A Novel Method to Differentiate Tonsil-Derived Mesenchymal Stem Cells In Vitro into Estrogen-Secreting Cells

Kim HY, Lee Y, Yoon HS, Kim YH, Cho KA, Woo SY, Kim HS, Park BY, Jung SC, Jo I, Park WJ, Park JW, Ryu KH

BACKGROUND: The advantages of tonsil-derived mesenchymal stem cells (TMSCs) over other mesenchymal stem cells (MSCs) include higher proliferation rates, various differentiation potentials, efficient immune-modulating capacity, and ease of obtainment. Specifically,...
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Understanding the Mechanistic Link between Bisphenol A and Cancer Stem Cells: A Cancer Prevention Perspective

Winz C, Suh N

Endocrine disruptors, such as bisphenol A (BPA), have become more frequently present in the environment as contaminants, especially in industrialized countries. Long-term effects of these environmental contaminants in humans are...
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Association of single-nucleotide polymorphisms in the ESR2 and FSHR genes with poor ovarian response in infertile Jordanian women

Sindiani AM, Batiha O, Al-zoubi E, Khadrawi S, Alsoukhni G, Alkofahi A, Alahmad NA, Shaaban S, Alshdaifat E, Abu-Halima M

Objective: Poor ovarian response (POR) refers to a subnormal follicular response that leads to a decrease in the quality and quantity of the eggs retrieved after ovarian stimulation during assisted...
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Estrogen Replacement Reduces Hearing Threshold Shifts and Cochlear Hair Cell Loss After Acoustic Overexposure in Ovariectomized Rats

Kim MT, Lee JH, Carpena NT, Lee MY, Chung PS, Jung JY

Objectives. The relationship of estrogen (the primary female sex hormone) with hearing function has been studied in both humans and animals. However, whether estrogen levels affect hearing remains uncertain. Therefore,...
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