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T-cell epitope specificity for Porphyromonas gingivalis heat shock protein in periodontitis

Lee JY, Lee JY, Choi JI

Due to considerably high degree of sequence homology between bacterial and human heat shock proteins (hsp), it has been widely thought that this protein might be involved in autoimmune disease...
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Identifying Novel B Cell Epitopes within Toxoplasma gondii GRA6

Wang Y, Wang G, Cai JP

The study of antigenic epitopes from Toxoplasma gondii has not only enhanced our understanding of the structure and function of antigens, the reactions between antigens and antibodies, and many other...
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Evaluation of Differential Antigenic Properties of Selected B - cell Epitopes from the HIV - 1 p24 Protein using Synthetic Peptides

Shin SY, Park JH, Lee MK, Hahm KS

  • KMID: 2083009
  • Korean J Immunol.
  • 1998 Mar;20(1):9-16.
The gag encoded p24 protein of human immunodeficiency virus-1 (HIV-1) is a major constitutent of the viral core, and is also known as one of the most immunodominant antigens in...
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Epitope specificity of Porphyromonas gingivalis heat shock protein for T-cell and/or B-cell in human atherosclerosis

Bak JG, Kim SJ, Choi JI

Since periodontal infections are suggested as risk factors for the development of cardiovascular diseases, the present study was performed to evaluate the T cell immune responses specific to Porphylomonas gingivalis(P....
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Recombinant influenza viruses as delivery vectors for hepatis B virus epitopes

Song JM, Lee KH, Seong BL

PURPOSE: Neuraminidase (NA) of influenza virus contains stalk region that shows a great deal of variability in both amino acid sequence and length. In this paper, we investigated generation of...
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Accelerating the development of a group A Streptococcus vaccine: an urgent public health need

Excler JL, Kim JH

Group A Streptococcus (GAS) infections cause substantial worldwide morbidity and mortality, mostly associated with suppurative complications such as pharyngitis, impetigo, and non-suppurative immune syndromes such as acute rheumatic fever, rheumatic...
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IgE-Binding Epitope Mapping and Tissue Localization of the Major American Cockroach Allergen Per a 2

Lee MF, Chang CW, Song PP, Hwang GY, Lin SJ, Chen YH

PURPOSE: Cockroaches are the second leading allergen in Taiwan. Sensitization to Per a 2, the major American cockroach allergen, correlates with clinical severity among patients with airway allergy, but there...
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In silico analysis of Brucella abortus Omp2b and in vitro expression of SOmp2b

Golshani M, Vaeznia N, Sahmani M, Bouzari S

PURPOSE: At present, there is no vaccine available for the prevention of human brucellosis. Brucella outer membrane protein 2b (Omp2b) is a 36 kD porin existed in common Brucella pathogens...
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Development of a Novel Subunit Vaccine Targeting Fusobacterium nucleatum FomA Porin Based on In Silico Analysis

Jeong K, Sao P, Park MJ, Lee H, Kim SH, Rhee JH, Lee SE

Selecting an appropriate antigen with optimal immunogenicity and physicochemical properties is a pivotal factor to develop a protein based subunit vaccine. Despite rapid progress in modern molecular cloning and recombinant...
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Multi-Epitope Fusion Protein Eg mefAg-1 as a Serodiagnostic Candidate for Cystic Echinococcosis in Sheep

Tianli L, Xifeng W, Zhenzhong , Lixia W, Xingxing Z, Jun Q, Qingling M, Shasha G, Ying C, Xuepeng C

Cystic echinococcosis (CE) in sheep is a hazardous zoonotic parasitic disease that is caused by Echinococcus granulosus (Eg). At present, serological test is an important diagnostic method for Eg infection...
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In silico analysis for identifying potential vaccine candidates against Staphylococcus aureus

Delfani S, Imani Fooladi AA, Mobarez AM, Emaneini M, Amani J, Sedighian

PURPOSE: Staphylococcus aureus is one of the most important causes of nosocomial and community-acquired infections. The increasing incidence of multiple antibiotic-resistant S. aureus strains and the emergence of vancomycin resistant...
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Genetic analysis of ORF5 of recent Korean porcine reproductive and respiratory syndrome viruses (PRRSVs) in viremic sera collected from MLV-vaccinating or non-vaccinating farms

Kim HK, Yang JS, Moon HJ, Park SJ, Luo Y, Lee CS, Song DS, Kang BK, Ann SK, Jun CH, Park BK

The 23 open reading frame (ORF) 5 sequences of Korean type II porcine reproductive and respiratory syndrome virus (PRRSV) were collected from viremic sera from the (modified live vaccine) MLV-vaccinating...
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Identification of Immunodominant B-cell Epitope Regions of Reticulocyte Binding Proteins in Plasmodium vivax by Protein Microarray Based Immunoscreening

Han JH, Li J, Wang B, Lee SK, Nyunt MH, Na S, Park JH, Han ET

Plasmodium falciparum can invade all stages of red blood cells, while Plasmodium vivax can invade only reticulocytes. Although many P. vivax proteins have been discovered, their functions are largely unknown....
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Specific B-cell Epitope of Per a 1: A Major Allergen of American Cockroach (Periplaneta americana) and Anatomical Localization

Sookrung N, Khetsuphan T, Chaisri U, Indrawattana N, Reamtong O, Chaicumpa , Tungtrongchitr A

PURPOSE: Cockroach (CR) is a common source of indoor allergens, and Per a 1 is a major American CR (Periplaneta americana) allergen; however, several attributes of this protein remain unknown....
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Emergence of vaccine-induced escape mutant of hepatitis b virus with multiple surface gene mutations in a korean child

Lee KM, Kim YS, Ko YY, Yoo BM, Lee KJ, Kim JH, Hahm KB, Cho SW

The S protein of hepatitis B virus is the principal component of virus envelope and the primary target of anti-HBs response. Mutants or variants that escape neutralization by anti-HBs have...
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