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Cystic fibrosis lung disease: Current perspectives

Jung JA

Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). These mutations alter the synthesis, processing, function, or...
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Renal intercalated cells and blood pressure regulation

Wall SM

Type B and non-A, non-B intercalated cells are found within the connecting tubule and the cortical collecting duct. Of these cell types, type B intercalated cells are known to mediate...
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Salt-sensitive genes and their relation to obesity

Cheon YP, Lee M

PURPOSE: Although it is well known thatmortality and morbidity due to cardiovascular diseases are higher in salt-sensitive subjects than in salt-resistant subjects, their underlying mechanisms related to obesity remain unclear....
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Pseudohypoaldosteronism in a newborn male with functional polymorphisms in the mineralocorticoid receptor genes

Jeong HA, Park YK, Jung YS, Nam MH, Nam HK, Lee KH, Rhie YJ

Hyponatremia and hyperkalemia in infancy can be attributed to various causes, originating from a variety of renal and genetic disorders. Pseudohypoaldosteronism type 1 (PHA1) is one of these disorders, causing...
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Salt Sensitivity and Hypertension: A Paradigm Shift from Kidney Malfunction to Vascular Endothelial Dysfunction

Choi HY, Park HC, Ha SK

Hypertension is a complex trait determined by both genetic and environmental factors and is a major public health problem due to its high prevalence and concomitant increase in the risk...
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Pseudohypoaldosteronism Type 1

Cheong HI

Pseudohypoaldosteronism (PHA), a rare syndrome of systemic or renal mineralocorticoid resistance, is clinically characterized by hyperkalemia, metabolic acidosis, and elevated plasma aldosterone levels with either renal salt wasting or hypertension....
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A Case of Autosomal Recessive Pseudohypoaldosteronism Type 1 with a Novel Mutation in the SCNN1A Gene

Kim SY, Lee JH, Cheong HI, Park YS

  • KMID: 2098923
  • J Korean Soc Pediatr Nephrol.
  • 2013 Oct;17(2):137-142.
Pseudohypoaldosteronism (PHA) is a condition characterized by renal salt wasting, hyperkalemia, and metabolic acidosis due to renal tubular resistance to aldosterone. Systemic PHA1 is a more severe condition caused by...
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Acute Hypoxia Activates an ENaC-like Channel in Rat Pheochromocytoma (PC12) Cells

Bae YJ, Yoo JC, Park N, Kang D, Han J, Hwang E, Park JY, Hong SG

Cells can resist and even recover from stress induced by acute hypoxia, whereas chronic hypoxia often leads to irreversible damage and eventually death. Although little is known about the response(s)...
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Upregulation of Prostasin in Nasal Polyps

Yoo JH, Park SJ, Lee HM, Lee SH, Lee SH, Kim TH

  • KMID: 2297579
  • J Rhinol.
  • 2012 May;19(1):50-54.
OBJECTIVES/HYPOTHESIS: Prostasin is a protease that activates epithelial sodium channels (ENaC), which mediate Na+ absorption across epithelial surfaces. Human nasal polyps absorb more ENaC-mediated Na+ than normal mucosa. We investigated...
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A case of pseudohypoaldosteronism type 1 with a mutation in the mineralocorticoid receptor gene

Lee SE, Jung YH, Han KH, Lee HK, Kang HG, Ha IS, Choi Y, Cheong HI

Pseudohypoaldosteronism type 1 (PHA1) is a rare form of mineralocorticoid resistance characterized in newborns by salt wasting with dehydration, hyperkalemia and failure to thrive. This disease is heterogeneous in etiology...
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Altered Regulation of Renal Sodium Transporters in Salt-Sensitive Hypertensive Rats Induced by Uninephrectomy

Jung JY, Lee JW, Kim S, Jung ES, Jang HR, Han JS, Joo KW

Uninephrectomy (uNx) in young rats causes salt-sensitive hypertension (SSH). Alterations of sodium handling in residual nephrons may play a role in the pathogenesis. Therefore, we evaluated the adaptive alterations of...
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Water and Sodium Regulation in Heart Failure

Bae EH, Ma SK

Heart failure is the pathophysiological state characterized by ventricular dysfunction and associated clinical symptoms. Decreased cardiac output or peripheral vascular resistance lead to arterial underfilling. That is an important signal...
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Pathophysiological Implications of Sodium Transporters and Water Channels in the Kidney

Kim SW, Ma SK, Bae EH, Park JW, Lee JU

  • KMID: 2253199
  • Korean J Nephrol.
  • 2009 Jan;28(1):1-9.
Renal sodium and water reabsorption occurs through epithelial sodium transporters and aquaporin (AQP) water channels in various segments of tubules. We have demonstrated altered regulation of these transporters and channels...
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Autonomic Neural Regulation of Sodium Transporters and Water Channels in Rat Submandibular Gland

Ryu SY, Jung H, Kim KY, Kim M, Lee JU

  • KMID: 2071622
  • Korean J Physiol Pharmacol.
  • 2006 Apr;10(2):65-69.
The present study was undertaken to explore the role of autonomic nerves in the regulation of sodium transporters and water channels in the salivary gland. Rats were denervated of their...
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Dysregulation of ENaC in Animal Models of Nephrotic Syndrome and Liver Cirrhosis

Kim SW

Nephrotic syndrome and liver cirrhosis are common clinical manifestations, and are associated with avid sodium retention leading to the development of edema and ascites. However, the mechanism for the sodium...
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Sympathetic and parasympathetic regulation of sodium transporters and water channels in rat submandibular gland

Jung H, Ryu SY

  • KMID: 2190348
  • J Korean Assoc Oral Maxillofac Surg.
  • 2006 Feb;32(1):1-7.
The present study was aimed to explore the role of sympathetic and parasympathetic nerves in the regulation of sodium transporters and water channels in the salivary gland. Rats were denervated...
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Chronic Furosemide Administration Alters Abundance of Sodium Transporters in Rat Kidney

Oh YK, Na KY, Lee JW, Chang HR, Park YS, Park J, Joo KW, Kim GH, Lee JS, Han JS

  • KMID: 2079291
  • Korean J Nephrol.
  • 2003 Mar;22(2):195-204.
BACKGROUND: Furosemide inhibit NaCl absorption in the thick ascending limb and produce an increase in distal delivery of Na+. We carried out semiquantitative immunoblotting and immunohistochemistry of rat kidneys to...
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