- Cystic fibrosis lung disease: Current perspectives
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Jung JA
- KMID: 2469112
- Allergy Asthma Respir Dis.
- 2020 Jan;8(1):3-8.
- doi: 10.4168/aard.2020.8.1.3
Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). These mutations alter the synthesis, processing, function, or... -
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- Renal intercalated cells and blood pressure regulation
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Wall SM
- KMID: 2405106
- Kidney Res Clin Pract.
- 2017 Dec;36(4):305-317.
- doi: 10.23876/j.krcp.2017.36.4.305
Type B and non-A, non-B intercalated cells are found within the connecting tubule and the cortical collecting duct. Of these cell types, type B intercalated cells are known to mediate... -
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- Salt-sensitive genes and their relation to obesity
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Cheon YP, Lee M
- KMID: 2386623
- J Nutr Health.
- 2017 Jun;50(3):217-224.
- doi: 10.4163/jnh.2017.50.3.217
PURPOSE: Although it is well known thatmortality and morbidity due to cardiovascular diseases are higher in salt-sensitive subjects than in salt-resistant subjects, their underlying mechanisms related to obesity remain unclear.... -
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- Pseudohypoaldosteronism in a newborn male with functional polymorphisms in the mineralocorticoid receptor genes
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Jeong HA, Park YK, Jung YS, Nam MH, Nam HK, Lee KH, Rhie YJ
- KMID: 2354701
- Ann Pediatr Endocrinol Metab.
- 2015 Dec;20(4):230-234.
- doi: 10.6065/apem.2015.20.4.230
Hyponatremia and hyperkalemia in infancy can be attributed to various causes, originating from a variety of renal and genetic disorders. Pseudohypoaldosteronism type 1 (PHA1) is one of these disorders, causing... -
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- Salt Sensitivity and Hypertension: A Paradigm Shift from Kidney Malfunction to Vascular Endothelial Dysfunction
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Choi HY, Park HC, Ha SK
- KMID: 2052337
- Electrolyte Blood Press.
- 2015 Jun;13(1):7-16.
- doi: 10.5049/EBP.2015.13.1.7
Hypertension is a complex trait determined by both genetic and environmental factors and is a major public health problem due to its high prevalence and concomitant increase in the risk... -
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- Pseudohypoaldosteronism Type 1
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Cheong HI
- KMID: 1811001
- J Genet Med.
- 2013 Dec;10(2):81-87.
- doi: 10.5734/JGM.2013.10.2.81
Pseudohypoaldosteronism (PHA), a rare syndrome of systemic or renal mineralocorticoid resistance, is clinically characterized by hyperkalemia, metabolic acidosis, and elevated plasma aldosterone levels with either renal salt wasting or hypertension.... -
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- A Case of Autosomal Recessive Pseudohypoaldosteronism Type 1 with a Novel Mutation in the SCNN1A Gene
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Kim SY, Lee JH, Cheong HI, Park YS
- KMID: 2098923
- J Korean Soc Pediatr Nephrol.
- 2013 Oct;17(2):137-142.
Pseudohypoaldosteronism (PHA) is a condition characterized by renal salt wasting, hyperkalemia, and metabolic acidosis due to renal tubular resistance to aldosterone. Systemic PHA1 is a more severe condition caused by... -
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- Acute Hypoxia Activates an ENaC-like Channel in Rat Pheochromocytoma (PC12) Cells
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Bae YJ, Yoo JC, Park N, Kang D, Han J, Hwang E, Park JY, Hong SG
- KMID: 1432764
- Korean J Physiol Pharmacol.
- 2013 Feb;17(1):57-64.
- doi: 10.4196/kjpp.2013.17.1.57
Cells can resist and even recover from stress induced by acute hypoxia, whereas chronic hypoxia often leads to irreversible damage and eventually death. Although little is known about the response(s)... -
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- Upregulation of Prostasin in Nasal Polyps
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Yoo JH, Park SJ, Lee HM, Lee SH, Lee SH, Kim TH
- KMID: 2297579
- J Rhinol.
- 2012 May;19(1):50-54.
OBJECTIVES/HYPOTHESIS: Prostasin is a protease that activates epithelial sodium channels (ENaC), which mediate Na+ absorption across epithelial surfaces. Human nasal polyps absorb more ENaC-mediated Na+ than normal mucosa. We investigated... -
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- A case of pseudohypoaldosteronism type 1 with a mutation in the mineralocorticoid receptor gene
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Lee SE, Jung YH, Han KH, Lee HK, Kang HG, Ha IS, Choi Y, Cheong HI
- KMID: 2073627
- Korean J Pediatr.
- 2011 Feb;54(2):90-93.
- doi: 10.3345/kjp.2011.54.2.90
Pseudohypoaldosteronism type 1 (PHA1) is a rare form of mineralocorticoid resistance characterized in newborns by salt wasting with dehydration, hyperkalemia and failure to thrive. This disease is heterogeneous in etiology... -
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- Altered Regulation of Renal Sodium Transporters in Salt-Sensitive Hypertensive Rats Induced by Uninephrectomy
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Jung JY, Lee JW, Kim S, Jung ES, Jang HR, Han JS, Joo KW
- KMID: 2052320
- Electrolyte Blood Press.
- 2009 Dec;7(2):58-66.
- doi: 10.5049/EBP.2009.7.2.58
Uninephrectomy (uNx) in young rats causes salt-sensitive hypertension (SSH). Alterations of sodium handling in residual nephrons may play a role in the pathogenesis. Therefore, we evaluated the adaptive alterations of... -
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- Water and Sodium Regulation in Heart Failure
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Bae EH, Ma SK
- KMID: 2052317
- Electrolyte Blood Press.
- 2009 Dec;7(2):38-41.
- doi: 10.5049/EBP.2009.7.2.38
Heart failure is the pathophysiological state characterized by ventricular dysfunction and associated clinical symptoms. Decreased cardiac output or peripheral vascular resistance lead to arterial underfilling. That is an important signal... -
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- Pathophysiological Implications of Sodium Transporters and Water Channels in the Kidney
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Kim SW, Ma SK, Bae EH, Park JW, Lee JU
- KMID: 2253199
- Korean J Nephrol.
- 2009 Jan;28(1):1-9.
Renal sodium and water reabsorption occurs through epithelial sodium transporters and aquaporin (AQP) water channels in various segments of tubules. We have demonstrated altered regulation of these transporters and channels... -
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- Autonomic Neural Regulation of Sodium Transporters and Water Channels in Rat Submandibular Gland
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Ryu SY, Jung H, Kim KY, Kim M, Lee JU
- KMID: 2071622
- Korean J Physiol Pharmacol.
- 2006 Apr;10(2):65-69.
The present study was undertaken to explore the role of autonomic nerves in the regulation of sodium transporters and water channels in the salivary gland. Rats were denervated of their... -
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- Dysregulation of ENaC in Animal Models of Nephrotic Syndrome and Liver Cirrhosis
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Kim SW
- KMID: 2052266
- Electrolyte Blood Press.
- 2006 Mar;4(1):23-34.
- doi: 10.5049/EBP.2006.4.1.23
Nephrotic syndrome and liver cirrhosis are common clinical manifestations, and are associated with avid sodium retention leading to the development of edema and ascites. However, the mechanism for the sodium... -
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- Sympathetic and parasympathetic regulation of sodium transporters and water channels in rat submandibular gland
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Jung H, Ryu SY
- KMID: 2190348
- J Korean Assoc Oral Maxillofac Surg.
- 2006 Feb;32(1):1-7.
The present study was aimed to explore the role of sympathetic and parasympathetic nerves in the regulation of sodium transporters and water channels in the salivary gland. Rats were denervated... -
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- Chronic Furosemide Administration Alters Abundance of Sodium Transporters in Rat Kidney
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Oh YK, Na KY, Lee JW, Chang HR, Park YS, Park J, Joo KW, Kim GH, Lee JS, Han JS
- KMID: 2079291
- Korean J Nephrol.
- 2003 Mar;22(2):195-204.
BACKGROUND: Furosemide inhibit NaCl absorption in the thick ascending limb and produce an increase in distal delivery of Na+. We carried out semiquantitative immunoblotting and immunohistochemistry of rat kidneys to... -
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