- Novel Influenza A (H1N1): Where Are We?
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Cheong HJ
- KMID: 1779148
- J Korean Med Sci.
- 2009 Jun;24(3):361-362.
- doi: 10.3346/jkms.2009.24.3.361
No abstract available. -
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- Effect of amino acids on inhibition of lactate dehydrogenase-X by gossypol
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Javed MH, Khan MA
- KMID: 755023
- Exp Mol Med.
- 1999 Mar;31(1):25-29.
Gossypol acetic acid (GAA) has been shown to have male antifertility effects, but there are pronounced differences among animal species. In the search of endogenous effector molecules, which interfere with the functions... -
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- The p38 mitogen-activated protein kinase is involved in stress-induced phospholipase D activation in vascular smooth muscle cells
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Min DS, Shin EY, Kim EG
- KMID: 1093596
- Exp Mol Med.
- 2002 Mar;34(1):38-46.
Oxidative stress has been implicated in mediation of vascular disorders. Earlier study showed that the exposure of vascular smooth muscle cells (VSMC) to pervanadate (hydrogen peroxide plus orthovanadate) resulted in... -
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- Co-activation of Gi and Gq proteins exerts synergistic effect on human platelet aggregation through activation of phospholipase C and Ca2+ signalling pathways
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Shah BH, Siddiqui A, Qureshi KA, Khan M, Rafi S, Ujan VA, Yakoob MY, Rasheed H, Saeed SA
- KMID: 755026
- Exp Mol Med.
- 1999 Mar;31(1):42-46.
Our previous studies have shown that subthreshold concentrations of two platelet agonists exert synergistic effects on platelet aggregation. Here we studied the mechanism of synergistic interaction of 5-hydroxytryptamine (5-HT) and epinephrine mediated platelet... -
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- Calcium-dependent and -independent mechanisms of P2Y receptor regulated anion secretion in polarized epithelia
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Wong HY, Ko WH
- KMID: 1026957
- J Korean Med Sci.
- 2000 Aug;15(Suppl):S63-S64.
- doi: 10.3346/jkms.2000.15.S.S63
No abstract available. -
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- Phospholipase D is involved in oxidative stress-induced migration of vascular smooth muscle cells via tyrosine phosphorylation and protein kinase C
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Kim J, Min G, Bae YS, Min DS
- KMID: 1380203
- Exp Mol Med.
- 2004 Apr;36(2):103-109.
Oxidative stress has been implicated in mediation of vascular disorders. In the presence of vanadate, H2O2 induced tyrosine phosphorylation of PLD1, protein kinase C-a (PKC-a), and other unidentified proteins in... -
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- Cross-linking of CD4 induces cytoskeletal association of CD4 and p56lck
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Ha-Lee YM, Lee YS, Kim YK, Sohn JW
- KMID: 927129
- Exp Mol Med.
- 2000 Mar;32(1):18-22.
A membrane glycoprotein CD4 functions as a co-receptor of a T lymphocyte. The co-receptor function has been attributed to a protein tyrosine kinase, p56lck, which is activated upon CD4 binding... -
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- Stimulation of macrophage function by S-antigen: production of nitric oxide
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Bae SR
- KMID: 754267
- Korean J Ophthalmol.
- 2000 Jun;14(1):12-19.
- doi: 10.3341/kjo.2000.14.1.12
In this study, we investigated whether retinal soluble proteins, such as S-antigen, play a role in the induction of nitric oxide by macrophages in vitro. Cells from the murine macrophage... -
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- c-Jun N-terminal kinase is involved in motility of endothelial cell
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Shin EY, Kim SY, Kim EG
- KMID: 1457542
- Exp Mol Med.
- 2001 Dec;33(4):276-283.
Cell motility is essential for a wide range of cellular activities including anigogenesis as well as metastasis of tumor cells. Ras has been implicated in cell migration and invasion, and... -
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- Stereological Comparison of the Effects of Pentoxifylline, Captopril, Simvastatin, and Tamoxifen on Kidney and Bladder Structure After Partial Urethral Obstruction in Rats
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Shirazi M, Soltani MR, Jahanabadi Z, Abdollahifar MA, Tanideh N, Noorafshan A
- KMID: 2069919
- Korean J Urol.
- 2014 Nov;55(11):756-763.
- doi: 10.4111/kju.2014.55.11.756
PURPOSE: Limited studies have shown antifibrotic effects of pentoxifylline, captopril, simvastatin, and tamoxifen. No comparisons are available of the effects of these drugs on prevention of renal and bladder changes... -
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- Calyculin A modulates activation of the NADPH-oxidase in Me2SO-differentiated HL-60 cells
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Park JI, Uhlinger D, Chung BS, Kim IH, Kwak JY
- KMID: 755011
- Exp Mol Med.
- 1998 Dec;30(4):214-220.
Human promyelocytic leukemia cells (HL-60) have been used as a model system in which to study the effects of protein phosphatase inhibitors on NADPH-oxidase activation. Since O2- is generated by... -
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- Stimulation of macrophage function by interphotoreceptor retinoid-binding protein: production of nitric oxide
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Bae SR
- KMID: 1127504
- Korean J Ophthalmol.
- 1999 Dec;13(2):57-64.
- doi: 10.3341/kjo.1999.13.2.57
In this study, we investigated whether retinal soluble proteins, such as interphotoreceptor retinoid-binding protein(IRBP), play a role in the induction of nitric oxide by macrophages in vitro. Cells from the... -
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- Induction of fibronectin gene expression by inhibitors of protein phosphatase type 2B in normal and transformed fibroblasts
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Rhew JH, Shin YA, Lee BH, Park RW, Kim IS
- KMID: 1029934
- Exp Mol Med.
- 1999 Jun;31(2):71-75.
Two intracellular signal pathways mediated by cAMP and protein kinase C (PKC) were involved in the regulation of FN gene expression (Lee et al., Exp. Mol. Med. 30: 240, 1998). In this... -
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- Mechanism of UV light-induced photorelaxation in isolated rat aorta
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Kim JH, Hong Y, Shim CS
- KMID: 1094645
- J Vet Sci.
- 2000 Dec;1(2):81-86.
Isolated rat thoracic aorta which is pharmacologically precontracted by phenylephrine induces photorelaxation when exposed to long wave length UV-light. The aim of the present study was to characterize the mechanism... -
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- Implication of phosphorylation of the myosin II regulatory light chain in insulin-stimulated GLUT4 translocation in 3T3-F442A adipocytes
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Choi YO, Ryu HJ, Kim HR, Song YS, Kim C, Lee W, Choe H, Leem CH, Jang YJ
- KMID: 1111411
- Exp Mol Med.
- 2006 Apr;38(2):180-189.
In adipocytes, insulin stimulates glucose transport primarily by promoting the translocation of GLUT4 to the plasma membrane. Requirements for Ca2+/ calmodulin during insulin-stimulated GLUT4 translocation have been demonstrated; however, the... -
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- Phosphorylation of phospholipase D1 and the modulation of its interaction with RhoA by cAMP-dependent protein kinase
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Jang MJ, Lee MJ, Park HY, Bae YS, Min DS, Ryu SH, Kwak JY
- KMID: 1380212
- Exp Mol Med.
- 2004 Apr;36(2):172-178.
Agents that elevate cellular cAMP are known to inhibit the activation of phospholipase D (PLD). We investigated whether PLD can be phosphorylated by cAMP-dependent protein kinase (PKA) and PKA-mediated phosphorylation... -
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- Tyrosine phosphatase and cytochrome P450 activity are critical in regulating store-operated calcium channels in human fibroblasts
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Lee KM
- KMID: 1115949
- Exp Mol Med.
- 2006 Dec;38(6):703-717.
Diverse signaling pathways have been proposed to regulate store-operated calcium entry (SOCE) in a wide variety of cell types. However, it still needs to be determined if all of these... -
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- ATP-induced focal adhesion kinase activity is negatively modulated by phospholipase D2 in PC12 cells
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Bae YS, Ryu SH
- KMID: 938879
- Exp Mol Med.
- 2001 Sep;33(3):150-155.
Extracellular ATP has been known to modulate various cellular responses including mitogenesis, secretion and morphogenic activity in neuronal cells. In the ATP-induced morphogenic activity, focal adhesion kinase(s) such as Fak... -
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- Interleukin-1 beta Induces MUC2 Gene Expression and Mucin Secretion via Activation of PKC-MEK/ERK,and PI3K in Human Airway Epithelial Cells
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Kim YD, Jeon JY, Woo HJ, Lee JC, Chung JH, Song SY, Yoon SK, Baek SH
- KMID: 648785
- J Korean Med Sci.
- 2002 Dec;17(6):765-771.
- doi: 10.3346/jkms.2002.17.6.765
Interleukin 1 beta (IL-1 beta), a proinflammatory cytokine, is related with inflammatory diseases and it up-regulates MUC2 gene expression and mucin secretion. This study was designed to investigate the... -
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- Effects of hypoxia on pulmonary vascular contractility
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Lee YH, Seo JH, Kang BS
- KMID: 711556
- Yonsei Med J.
- 1998 Jun;39(3):261-267.
- doi: 10.3349/ymj.1998.39.3.261
Although hypoxic pulmonary vasoconstriction (HPV) has been recognized by many researchers, the precise mechanism remains unknown. As isolated pulmonary arteries will constrict in vitro in the response to hypoxia, the... -
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