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GPR40 Agonism Modulates Inflammatory Reactions in Vascular Endothelial Cells

Kim JW, Roh E, Choi KM, Yoo HJ, Hwang HJ, Baik SH

Endothelial dysfunction is strongly linked with inflammatory responses, which can impact cardiovascular disease. Recently, G protein-coupled receptor 40 (GPR40) has been investigated as a modulator of metabolic stress; however, the...
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Expression of ICAM-1 in Blood Vascular Endothelium and Tissues in Human Premalignant Lesion and Gastric/Hepatocellular Carcinomas

Kang L, Kim M, Lee YM

Background/Aims: Angiogenesis is essential for the outgrowth and metastasis of tumors. The structure and characteristics of tumor vasculature differ from those of normal vessels. We compared the characteristics of differentially...
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Glial and Vascular Cell Regulation of the Blood-Brain Barrier in Diabetes

Li X, Cai Y, Zhang Z, Zhou J

As a structural barrier, the blood-brain barrier (BBB) is located at the interface between the brain parenchyma and blood, and modulates communication between the brain and blood microenvironment to maintain...
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Mechanisms of tissue factor induction by Porphyromonas gingivalis in human endothelial cells

Kim SH, Jung JY, Kim WJ, Kim OJ, Kim Y, Kang IC

Associations between periodontal infection and cardiovascular disease have been documented. Porphyromonas gingivalis is a well-established periodontal pathogen, and tissue factor (TF) is a key initiator of the coagulation cascade. In...
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A Novel Hypothesis and Characterization to Isolate Microvascular Endothelial Cells Simultaneously with AdiposeDerived Stem Cells from the Human Adipose-Derived Stromal Vascular Fraction

Ryu YH, Moon SH, Kim KJ, Jun YJ, Oh DY, Kim SH, Rhie JW

BACKGROUND: Angiogenesis and vasculogenesis are essential processes for successful tissue regeneration in tissue engineering and regenerative medicine. The adipose-derived stromal vascular fraction (SVF) is not only a source of adipose...
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Electrospun Microvasculature for Rapid Vascular Network Restoration

Han JH, Ko UH, Kim HJ, Kim S, Jeon JS, Shin JH

BACKGROUND: Sufficient blood supply through neo-vasculature is a major challenge in cell therapy and tissue engineering in order to support the growth, function, and viability of implanted cells. However, depending...
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Gamma-aminobutyric acid-salt attenuated high cholesterol/high salt diet induced hypertension in mice

Son M, Oh S, Lee HS, Choi J, Lee BJ, Park JH, Park CH, Son KH, Byun K

Excessive salt intake induces hypertension, but several gamma-aminobutyric acid (GABA) supplements have been shown to reduce blood pressure. GABAsalt, a fermented salt by L. brevis BJ20 containing GABA was prepared...
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2,3,5,4’-Tetrahydroxystilbene-2-O-β-D-Glucoside modulated human umbilical vein endothelial cells injury under oxidative stress

Guo Y, Fan W, Cao S, Xie Y, Hong J, Zhou H, Wan H, Jin B

Endothelial cell injury is a major contributor to cardiovascular diseases. The 2,3,5,4’-Tetrahydroxystilbene-2-O-β-D-Glucoside (TSG) contributes to alleviate human umbilical vein endothelial cells (HUVECs) injury through mechanisms still know a little. This study...
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Effect of Cyclosporine A-induced Senescence on Cultured Human Corneal Endothelial Cells

Jang YK, Chung TY, Shin YJ

Purpose: To investigate the in vitro effect of cyclosporine A (CsA)-induced senescence on human corneal endothelial cells (HCECs). Methods: HCECs were cultured and incubated with 0-100 µM CsA. Senescence-associated β–galactosidase (SA-β-gal)...
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Pre-Seeding of Simple Electrospun Scaffolds with a Combinationof Endothelial Cells and Fibroblasts Strongly PromotesAngiogenesis

Dikici S, Claeyssens F, MacNeil S

BACKGROUND: Introduction of pro-angiogenic cells into tissue-engineered (TE) constructs (prevascularisation) is apromising approach to overcome delayed neovascularisation of such constructs post-implantation. Accordingly, in thisstudy, we examined the contribution of human...
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Effects on Wound Healing of Human-Induced Pluripotent Stem Cell-Derived Cells Similar to Endothelial Colony-Forming Cells

Kim SH, Nam JH, Lee MR, Hwang Y, Park ES

Background: Human-induced pluripotent stem cells (hiPSCs) complement the disadvantages of conventional embryonic stem cells and adult stem cells, and have the advantages of simplicity of production and pluripotency. Some recent...
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Curcumin Attenuates Acrolein-induced COX-2 Expression and Prostaglandin Production in Human Umbilical Vein Endothelial Cells

Lee SE, Park HR, Jeon S, Han D, Park YS

OBJECTIVE: Inflammation is crucial to limiting vascular disease. Previously we reported that acrolein, a known toxin in tobacco smoke, might play an important role in the progression of atherosclerosis via...
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Optimization of Microenvironments Inducing Differentiation of Tonsil-Derived Mesenchymal Stem Cells into Endothelial Cell-Like Cells

Oh SY, Choi DH, Jin YM, Yu Y, Kim HY, Kim G, Park YS, Jo I

BACKGROUND: Stem cell engineering is appealing consideration for regenerating damaged endothelial cells (ECs) because stem cells can differentiate into EC-like cells. In this study, we demonstrate that tonsil-derived mesenchymal stem...
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Involvement of Orai1 in tunicamycin-induced endothelial dysfunction

Yang H, Xue Y, Kuang S, Zhang M, Chen J, Liu L, Shan Z, Lin Q, Li X, Yang M, Zhou H, Rao F, Deng C

Endoplasmic reticulum (ER) stress is mediated by disturbance of Ca²⁺ homeostasis. The store-operated calcium (SOC) channel is the primary Ca²⁺ channel in non-excitable cells, but its participation in agent-induced ER...
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Autophagy Is a Potential Target for Enhancing the Anti-Angiogenic Effect of Mebendazole in Endothelial Cells

Sung SJ, Kim HK, Hong YK, Joe YA

Mebendazole (MBZ), a microtubule depolymerizing drug commonly used for the treatment of helminthic infections, has recently been noted as a repositioning candidate for angiogenesis inhibition and cancer therapy. However, the...
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Pathophysiology of Diabetic Retinopathy: The Old and the New

Kusuhara S, Fukushima , Ogura S, Inoue N, Uemura A

Vision loss in diabetic retinopathy (DR) is ascribed primarily to retinal vascular abnormalities—including hyperpermeability, hypoperfusion, and neoangiogenesis—that eventually lead to anatomical and functional alterations in retinal neurons and glial cells....
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Angiogenesis and the prevention of alveolar osteitis: a review study

Saghiri MA, Asatourian A, Sheibani N

Angiogenesis is one of the essential processes that occur during wound healing. It is responsible for providing immunity as well as the regenerative cells, nutrition, and oxygen needed for the...
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In vitro treatment of lipopolysaccharide increases invasion of Pasteurella multocida serotype B:2 into bovine aortic endothelial cells

Yap SK, Zakaria Z, Othman SS, Omar AR

Pasteurella multocida serotype B:2 causes hemorrhagic septicemia in cattle and buffalo. The invasion mechanism of the bacterium when invading the bloodstream is unclear. This study aimed to characterize the effects...
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Relationship between Pericytes and Endothelial Cells in Retinal Neovascularization: A Histological and Immunofluorescent Study of Retinal Angiogenesis

Choi SH, Chung M, Park SW, Jeon NL, Kim JH, Yu YS

PURPOSE: To evaluate the relationship between pericytes and endothelial cells in retinal neovascularization through histological and immunofluorescent studies. METHODS: C57BL/6J mice were exposed to hyperoxia from postnatal day (P) 7 to...
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Myricetin Inhibits Angiogenesis by Inducing Apoptosis and Suppressing PI3K/Akt/mTOR Signaling in Endothelial Cells

Kim GD

BACKGROUND: Myricetin has been shown to possess potential antiangiogenic effects in endothelial cells. However, the underlying mechanisms are not fully understood. Therefore, we evaluated its antiangiogenic effects in human umbilical...
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