- Studies on rat liver nuclear DNA damaged by chemical carcinogen (3'-Me DAB) and AP DNA endonuclease. I. Purification and some properties of AP DNA endonucleases in rat liver chromatin
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Kim YS, Kim JW, Lee SE, Oh SH
- KMID: 1421490
- J Korean Med Sci.
- 1990 Sep;5(3):127-135.
- doi: 10.3346/jkms.1990.5.3.127
Three kinds of apurinic/apyrimidinic (AP) DNA endonuclease, APcI, APcII, APcIII, were purified from rat liver chromatin through 1M KCl extraction, DEAE-trisacryl ion exchange chromatography. Sephadex G-150 gel filtration and AP... -
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- Studies on rat liver nuclear DNA damaged by chemical carcinogen (3'-Me DAB) and AP DNA endonuclease. II. Kinetic properties of AP DNA endonucleases in rat liver chromatin
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Kim YS, Kim JW, Lee SE, Oh SH
- KMID: 1421491
- J Korean Med Sci.
- 1990 Sep;5(3):137-143.
- doi: 10.3346/jkms.1990.5.3.137
An experiment was designed to investigate the reaction mechanism of AP (apurinic or apyrimidinic) DNA endonucleases (APcI, APcII, APcIII) purified from rat liver chromatin. Sulfhydryl compounds (2-mercaptoethanol, dithiothreitol) brought about... -
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- Down-regulation of human FEN-1 gene expression during differentiation of promyelocytic leukemia cells
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Kim IS
- KMID: 755017
- Exp Mol Med.
- 1998 Dec;30(4):252-256.
Flap endo/exonuclease-1 (FEN-1) recognizes 5'-flap DNA structures that have been proposed to be important intermediates in DNA replication, repair and recombination, and cleaves the double strand-single strand junction of flap ... -
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- Human FEN-1 can process the 5'-flap DNA of CTG/CAG triplet repeat derived from human genetic diseases by length and sequence dependent manner
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Lee SM, Park MS
- KMID: 931883
- Exp Mol Med.
- 2002 Sep;34(4):313-317.
Trinucleotide repeat (TNR) instability can cause a variety of human genetic diseases including myotonic dystrophy and Huntington's disease. Recent genetic data show that instability of the CAG/CTG repeat DNA... -
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- Up-regulation of Bax and endonuclease G, and down-modulation of Bcl-X(L) involved in cardiotoxin III-induced apoptosis in K562 cells
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Yang SH, Chien CM, Lu MC, Lin YH, Hu XW, Lin SR
- KMID: 1110128
- Exp Mol Med.
- 2006 Aug;38(4):435-444.
Cardiotoxin III (CTX III), a basic polypeptide with 60 amino acid residues isolated from Naja naja atra venom, has been reported to have anticancer activity. CTX III-induced K562 cell apoptosis... -
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