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Changing Patterns of Causative Pathogens over Time and Efficacy of Empirical Antibiotic Therapies in Acute Cholangitis with Bacteremia

Jeong HT, Song JE, Kim HG, Han J

Background/Aims: To select appropriate empirical antibiotics, updates on the changes in pathogens are essential. We aimed to investigate the changes in pathogens and their antibiotic susceptibility in acute cholangitis (AC)...
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Acute uncomplicated cystitis in the emergency department: prevalence of antimicrobial resistance among uropathogens and appropriate antimicrobial treatment

Chung SY, Kim Y, Jeong R, Lee K, Yu W, Yoon Y, Choi S

  • KMID: 2535906
  • J Korean Soc Emerg Med.
  • 2022 Oct;33(5):480-486.
Objective: This study analyzed the urine cultures of emergency department patients diagnosed with acute uncomplicated cystitis and determined the antimicrobial resistance and appropriate treatment for our region. Methods: Results of urine...
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Antimicrobial Susceptibility Patterns and Clinical Characteristics of Corynebacterium striatum Cases from 2018 to 2021

Choi I, Lee Y

Background: Corynebacterium striatum is part of the normal flora of the skin, oral cavity, and intestine. However, it can be a pathogen causing endocarditis, pneumonia, arthritis, and meningitis occasionally. We...
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Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells

Park D, Lee JH, Yoon SP

Benzimidazole anthelmintic agents have been recently repurposed to overcome cancers resistant to conventional therapies. To evaluate the anti-cancer effects of benzimidazole on resistant cells, various cell death pathways were investigated...
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Bismuth-Based Quadruple Therapy versus MetronidazoleIntensified Triple Therapy as a First-Line Treatment for Clarithromycin-Resistant Helicobacter pylori Infection: A Multicenter Randomized Controlled Trial

Seo SI, Lim H, Bang CS, Yang YJ, Baik GH, Lee SP, Jang HJ, Kae SH, Kim J, Kim HY, Shin WG

Background/Aims: Clarithromycin resistance is a main factor for treatment failure in the context of Helicobacter pylori infection. However, the treatment regimen for clarithromycin-resistant H. pylori infection has not yet been determined....
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Changes of Causative Organism and Antimicrobial Resistance in Urinary Tract Infections After the COVID-19

Choi YH, Tae JH, Lee MK, Kim TH

Purpose: During the coronavirus disease 2019 (COVID-19) pandemic, several studies reported changes in the distribution of microorganisms that cause major legal, respiratory, and gastrointestinal infectious diseases and increases in the...
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Implementation of antimicrobial stewardship programs

Kwon KT

Background: The antimicrobial stewardship program (ASP) is a coordinated intervention designed to improve and measure the appropriate antibiotics use by selecting an optimal antibiotic drug regimen, including dosing, therapy duration,...
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Antibiotics for multidrug-resistant gram-negative bacteria

Kang CI

Background: Increase in antimicrobial-resistant bacteria continues to be challenge to physicians. Particularly, multidrug-resistant (MDR) gram-negative bacilli (GNB), such as extended-spectrum beta-lactamase (ESBL)-producers and carbapenem-resistant pathogens, are becoming a major human...
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Antibiotics for multidrug-resistant gram-positive bacteria

Song KH

Background: Antimicrobial resistance is a major global threat to public health and is associated with increased morbidity and mortality. A few therapeutic options for the treatment of multidrug resistant (MDR)...
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Current status of multidrug-resistant bacteria

Kim D, Jeong SH

Background: The dissemination of multidrug-resistant (MDR) pathogen is of major public health concern as it leads to increased mortality rate, length of hospital stays, and medical expenses. Current Concepts: Korean Government...
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Multidrug-resistant bacteria: a national challenge requiring urgent addressal

Kim NJ

Background: Multidrug-resistant bacterial infections are a worldwide threat owing to their increased prevalence, and poor prognosis due to inadequate antibacterial drugs. Current Concepts: Until 2019, several new antibacterial agents, targeting gram-positive...
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Epidemiological characteristics of carbapenemresistant Enterobacteriaceae and carbapenem-resistant Acinetobacter baumannii in a tertiary referral hospital in Korea

Kang S, Jeong IS

Objectives This study aimed to identify the epidemiological characteristics of patients with carbapenem-resistant Enterobacteriaceae and Acinetobacter baumannii (CRE/CRAB) isolates in a tertiary referral hospital in Korea. Methods We collected and analyzed...
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Detection and Control of Candida auris in Healthcare Settings

Kwon YJ, Shin JH

Since it was first reported in 2009 after isolation from ear cultures of 1 Japanese patient and 15 Korean patients, Candida auris infections have been reported in at least 35...
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Bloodstream Infections in Patients with Hematologic Diseases: Causative Organisms and Factors Associated with Resistance

Choi H, Ahn H, Lee R, Cho SY, Lee DG

Background: Patients with hematologic diseases are at high risk of bloodstream infections (BSIs). This study aimed to analyze clinical features and distributions of microorganisms in patients with hematologic diseases presenting...
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Clinical Implication of Candida Score in Multidrug-Resistant Pneumonia with Airway Candida Colonization

La Y, Kwon DE, Jeon S, Lee S, Lee KH, Han SH, Song YG

Background: The growth of Candida in respiratory secretions is usually considered colonization, and antifungal therapy is rarely required. The role of Candida colonization in the progression of bacterial pneumonia remains...
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Chemosensitizing effect and mechanism of imperatorin on the anti-tumor activity of doxorubicin in tumor cells and transplantation tumor model

Liang Xl, Ji Mm, Liao Zg, Zhao Gw, Tang Xl, Dong W

Multidrug resistance of tumors has been a severe obstacle to the success of cancer chemotherapy. The study wants to investigate the reversal effects of imperatorin (IMP) on doxorubicin (DOX) resistance...
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Antibiotic therapy of chronic bacterial prostatitis is more effective considering antibiotic susceptibility of all pathogens isolated

Kogan MI, Ibishev KS, Naboka YL, Gudima IA, Ferzauli AK, Ismailov RS, Naber KG

Purpose: Because of the insufficient efficacy of the current treatment of chronic bacterial prostatitis (CBP), it is justified to search for a more effective antibiotic therapy (ABT). Materials and Methods: This...
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Urushiol V Suppresses Cell Proliferation and Enhances Antitumor Activity of 5-FU in Human Colon Cancer Cells by Downregulating FoxM1

Jeong JH, Ryu JH

Colorectal cancer (CRC) is one of the most common malignant tumor. 5-FU is commonly used for the treatment of CRC. However, the development of drug resistance in tumor chemotherapy can...
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Challenges in the Use of Targeted Therapies in Non–Small Cell Lung Cancer

Rivera-Concepcion J, Uprety D, Adjei AA

Precision oncology has fundamentally changed how we diagnose and treat cancer. In recent years, there has been a significant change in the management of patients with oncogene-addicted advanced-stage NSCLC. Increasing...
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Genetic Polymorphisms in the pvdhfr, pvmdr1, and pvdhps Genes of Plasmodium vivax in Patients at a Secondary Hospital in South Korea

Lee J, Kim H, Kim YR, Lee H

Background: Plasmodium vivax is a major pathogen that causes malaria in South Korea. Several genetic polymorphisms in dihydrofolate reductase (pvdhfr), P. vivax multidrug resistance protein 1 (pvmdr1 ), and P. vivax...
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