- PharmacoNER Tagger: a deep learning-based tool for automatically finding chemicals and drugs in Spanish medical texts
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Armengol-Estapé J, Soares F, Marimon M, Krallinger M
- KMID: 2462025
- Genomics Inform.
- 2019 Jun;17(2):e15.
- doi: 10.5808/GI.2019.17.2.e15
Automatically detecting mentions of pharmaceutical drugs and chemical substances is key for the subsequent extraction of relations of chemicals with other biomedical entities such as genes, proteins, diseases, adverse reactions... -
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- A review of computational drug repurposing
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Park K
- KMID: 2457572
- Transl Clin Pharmacol.
- 2019 Jun;27(2):59-63.
- doi: 10.12793/tcp.2019.27.2.59
Although sciences and technology have progressed rapidly, de novo drug development has been a costly and time-consuming process over the past decades. In view of these circumstances, ‘drug repurposing’ (or... -
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- Guanabenz Acetate Induces Endoplasmic Reticulum Stress–Related Cell Death in Hepatocellular Carcinoma Cells
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Kang HJ, Seol HS, Lee SE, Suh YA, Kim J, Jang SJ, Yu E
- KMID: 2465448
- J Pathol Transl Med.
- 2019 Mar;53(2):94-103.
- doi: 10.4132/jptm.2019.01.14
BACKGROUND: Development of chemotherapeutics for the treatment of advanced hepatocellular carcinoma (HCC) has been lagging. Screening of candidate therapeutic agents by using patient-derived preclinical models may facilitate drug discovery for... -
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- Current state and outlook for drug repositioning anticipated in the field of ovarian cancer
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Kobayashi , Banno K, Kunitomi H, Tominaga E, Aoki D
- KMID: 2429579
- J Gynecol Oncol.
- 2019 Jan;30(1):e10.
- doi: 10.3802/jgo.2019.30.e10
Ovarian cancer is the seventh most common cancer and the eighth most common cause of cancer mortality in women. Although standard chemotherapy is the established treatment for ovarian cancer, the... -
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- Metabolomics Approach to Explore the Effects of Rebamipide on Inflammatory Arthritis Using Ultra Performance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry
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Moon SJ, Lee SH, Jung BH, Min JK
- KMID: 2389060
- J Rheum Dis.
- 2017 Aug;24(4):192-202.
- doi: 10.4078/jrd.2017.24.4.192
OBJECTIVE: Rebampide is a gastroprotective agent used to treat gastritis. It possesses anti-inflammatory and anti-arthritis effects, but the mechanisms of these effects are not well understood. The objective of this... -
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- The Role of Common Pharmaceutical Agents on the Prevention and Treatment of Pancreatic Cancer
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Amin S, Boffetta P, Lucas AL
- KMID: 2412062
- Gut Liver.
- 2016 Sep;10(5):665-671.
- doi: 10.5009/gnl15451
Survival from pancreatic cancer remains poor. Conventional treatment has resulted in only marginal improvements in survival compared with survival in the previous several decades. Thus, considerable interest has emerged regarding... -
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- Emerging strategies for the treatment of pulmonary tuberculosis: promise and limitations?
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Yew WW, Koh WJ
- KMID: 2373768
- Korean J Intern Med.
- 2016 Jan;31(1):15-29.
- doi: 10.3904/kjim.2016.31.1.15
A worsening scenario of drug-resistant tuberculosis has increased the need for new treatment strategies to tackle this worldwide emergency. There is a pressing need to simplify and shorten the current... -
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- Gefitinib Inhibits the Growth of Toxoplasma gondii in HeLa Cells
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Yang Z, Ahn HJ, Nam HW
- KMID: 1792207
- Korean J Parasitol.
- 2014 Aug;52(4):439-441.
- doi: 10.3347/kjp.2014.52.4.439
Toxoplasma gondii is the causative agent of toxoplasmosis with symptoms of congenital neurological and ocular diseases and acquired lymphadenitis, retinochoroiditis, and meningoencephalitis. Small molecules which block the activity of protein... -
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- Drug Similarity Search Based on Combined Signatures in Gene Expression Profiles
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Cha K, Kim MS, Oh K, Shin H, Yi GS
- KMID: 2166739
- Healthc Inform Res.
- 2014 Jan;20(1):52-60.
- doi: 10.4258/hir.2014.20.1.52
OBJECTIVES: Recently, comparison of drug responses on gene expression has been a major approach to identifying the functional similarity of drugs. Previous studies have mostly focused on a single feature,... -
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