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Invertebrate Model Organisms as a Platform to Investigate Rare Human Neurological Diseases

Lee JH

Patients suffering from rare human diseases often go through a painful journey for finding a definite molecular diagnosis prerequisite of appropriate cures. With a novel variant isolated from a single...
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A Rare Stinkhorn Fungus Itajahya rosea Attract Drosophila by Producing Chemical Attractants

Borde M, Kshirsagar Y, Jadhav R, Baghela A

Itajahya rosea was found growing in association with Leucaena leucocephala plants at Savitribai Phule Pune University campus in India. The species identity was confirmed by phylogenetic analysis based on ITS...
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L-DOPA-Induced Dyskinesia in a Genetic Drosophila Model of Parkinson’s Disease

Blosser JA, Podolsky E, Lee D

  • KMID: 2506532
  • Exp Neurobiol.
  • 2020 Aug;29(4):273-284.
  • doi: 10.5607/en20028
Motor symptoms in Parkinson’s disease (PD) are directly related to the reduction of a neurotransmitter dopamine. Therefore, its precursor LDOPA became the gold standard for PD treatment. However, chronic use...
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Targeted Downregulation of kdm4a Ameliorates Tau-engendered Defects in Drosophila melanogaster

Park SY, Seo J, Chun YS

BACKGROUND: Tauopathies, a class of neurodegenerative diseases that includes Alzheimer's disease (AD), are characterized by the deposition of neurofibrillary tangles composed of hyperphosphorylated tau protein in the human brain. As...
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Adzuki bean (Vigna angularis) extract reduces amyloid-β aggregation and delays cognitive impairment in Drosophila models of Alzheimer's disease

Miyazaki H, Okamoto Y, Motoi A, Watanabe T, Katayama S, Kawahara S, Makabe H, Fujii H, Yonekura S

BACKGROUND/OBJECTIVES: Alzheimer's disease is a neurodegenerative disease that induces symptoms such as a decrease in motor function and cognitive impairment. Increases in the aggregation and deposition of amyloid beta protein...
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Drosophila melanogaster as a Model for Studying Aspergillus fumigatus

AL-Maliki , Martinez S, Piszczatowski P, Bennett JW

Drosophila melanogaster is a useful model organism that offers essential insights into developmental and cellular processes shared with humans, which has been adapted for large scale analysis of medically important...
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Optogenetic Rescue of Locomotor Dysfunction and Dopaminergic Degeneration Caused by Alpha-Synuclein and EKO Genes

Qi C, Varga S, Oh SJ, Lee CJ, Lee D

α-Synuclein (α-Syn) is a small presynaptic protein and its mutant forms (e.g. A53T) are known to be directly associated with Parkinson's disease (PD). Pathophysiological mechanisms underlying α-Syn-mediated neurodegeneration in PD...
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Drosophila Homolog of Human KIF22 at the Autism-Linked 16p11.2 Loci Influences Synaptic Connectivity at Larval Neuromuscular Junctions

Park SM, Littleton , Park HR, Lee JH

Copy number variations at multiple chromosomal loci, including 16p11.2, have recently been implicated in the pathogenesis of autism spectrum disorder (ASD), a neurodevelopmental disease that affects 1~3% of children worldwide....
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Defensive Behavior against Noxious Heat Stimuli Is Declined with Aging Due to Decreased Pain-Associated Gene Expression in Drosophila

Ghimire S, Kim MS

Aging is defined as a collective process that alters organism's functional capacity and appearance over the course of life. Apart from an increase in susceptibility to many diseases, aging affects...
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Taste Sensation in Drosophila melanoganster

Lee Y, Poudel S

Animals find nutritious foods to survive, while avoiding aversive and toxic chemicals through the chemosensory faculties of olfaction and taste. The olfaction is comparatively well characterized, but the studies of...
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The Synergistic Effects of Antimicrobial Peptides on the Growth Inhibition of Salmonella Typhimurium through Imd Pathway in Drosophila Intestine

Lim YJ, Jo YH, Kim HJ, Park JK

Some Bacillus species present in fermented foods are regarded as probiotics because of their ability to modulate the prevention of some intestinal infections and the modulation of the inflammatory immune...
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Korean Red Ginseng Tonic Extends Lifespan in D. melanogaster

Kim MS

  • KMID: 1502494
  • Biomol Ther.
  • 2013 May;21(3):241-245.
Aging is the single most important risk factor that increases susceptibility to many forms of diseases. As such, much effort has been put forward to elucidate the mechanisms behind the...
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Enhancement of Protein Productivity of Recombinant Hepatitis A Virus VP1 in Stably Transfected Drosophila melanogaster S2 Cells

Jeon HB, Park JH, Lee HH, Kim DH, Lee HY, Shon DH, Kim W, Chung IS

The effect of DMSO and sodium butyrate on the production of recombinant hepatitis A virus (HAV) capsid protein VP1 was evaluated and optimized in the culture of stably transfected Drosophila...
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Characterization of the Rho GTPase-Activating Protein RhoGAP68F

Nahm M, Lee S

Rho small GTPases control multiple aspects of neuronal morphogenesis by regulating the assembly and organization of the actin cytoskeleton. Although they are negatively regulated by GTPase activating proteins (GAPs), the...
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Further understanding of fat biology: Lessons from a fat fly

Hong JW, Park KW

Obesity is a leading risk factor for insulin resistance, hypertension, hyperlipidemia, and cardiovascular complications, collectively referred to as metabolic diseases. Given the prevalence of obesity and its associated medical problems,...
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Low-dose Gamma-irradiation Effect on Early Stage Development and Lifespan in Various Strains of Drosophila melanogaster

Lee JW, Seong KM, Kim CS, Nam SY, Yang KH, Jin YW

  • KMID: 2075037
  • Korean J Occup Environ Med.
  • 2008 Sep;20(3):225-232.
OBJECTIVES: Although ionizing radiation is recognized as being harmful to humans, debate continues regarding the effects of low doses of ionizing radiation. Some studies have reported that low doses of...
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Expression of Expanded Polyglutamine Disease Proteins in Drosophila (Drosophila Polyglutamine Disease Models)

Shin SM, Paik KH, Jin DK

  • KMID: 2278680
  • Korean J Pediatr.
  • 2005 Apr;48(4):425-432.
PURPOSE: Polyglutamine diseases are a group of diseases caused by the expansion of a polyglutamine tract in the protein. The present study was performed to verify if polyglutamine disease transgenic...
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Cytotoxicological Effect of Tebufenozide, an Insect Growth Regulator (IGR) : Stimulation of Filamentous Actin Reorganization and Enhancement of Hsp27 Expression in Drosophila Kc Cells

Hwang JN, Jung HJ, Seo YR

  • KMID: 1611499
  • Korean J Physiol Pharmacol.
  • 2004 Dec;8(6):351-354.
The cytotoxicological responses to insect growth regulator (IGR), using tebufenozide as ecdysteroid mimic, were investigated in Drosophila Kc cells. Treatment of Kc cells with tebufenozide showed significant growth inhibition and...
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