- Downregulation of N-myc and STAT Interactor Protein Predicts Aggressive Tumor Behavior and Poor Prognosis in Invasive Ductal Carcinoma
-
Choi JE, Hyun CL, Jin MS, Lee KM, Moon JH, Ryu HS
- KMID: 2470880
- J Breast Cancer.
- 2020 Feb;23(1):36-46.
- doi: 10.4048/jbc.2020.23.e12
PURPOSE: We investigated the expression of the N-myc and STAT interactor (NMI) protein in invasive ductal carcinoma tissue and estimated its clinicopathologic significance as a prognostic factor. The expression levels... -
- CITED
-
- Close
- SHARE
-
- Close
- Overcoming the Intrinsic Gefitinib-resistance via Downregulation of AXL in Non-small Cell Lung Cancer
-
Jeong I, Song J, Bae SY, Lee SK
- KMID: 2468811
- J Cancer Prev.
- 2019 Dec;24(4):217-223.
- doi: 10.15430/JCP.2019.24.4.217
BACKGROUND: Resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib, is a limited factor in the treatment of non-small-cell lung cancer (NSCLC) patients. Therefore, ongoing studies... -
- CITED
-
- Close
- SHARE
-
- Close
- Gemigliptin Attenuates Renal Fibrosis Through Down-Regulation of the NLRP3 Inflammasome
-
Seo JB, Choi YK, Woo HI, Jung YA, Lee S, Lee S, Park M, Lee IK, Jung GS, Park KG
- KMID: 2466504
- Diabetes Metab J.
- 2019 Dec;43(6):830-839.
- doi: 10.4093/dmj.2018.0181
BACKGROUND: The hypoglycemic drugs dipeptidyl peptidase-4 (DPP-4) inhibitors have proven protective effects on diabetic kidney disease, including renal fibrosis. Although NOD-like receptor protein 3 (NLRP3) inflammasome activation is known to... -
- CITED
-
- Close
- SHARE
-
- Close
- Exosomal miR-181b-5p Downregulation in Ascites Serves as a Potential Diagnostic Biomarker for Gastric Cancer-associated Malignant Ascites
-
Yun J, Han SB, Kim HJ, Go SI, Lee WS, Bae WK, Cho SH, Song EK, Lee OJ, Kim HK, Yang Y, Kwon J, Chae HB, Lee KH, Han HS
- KMID: 2458830
- J Gastric Cancer.
- 2019 Sep;19(3):301-314.
- doi: 10.5230/jgc.2019.19.e27
PURPOSE: Peritoneal carcinomatosis in gastric cancer (GC) patients results in extremely poor prognosis. Malignant ascites samples are the most appropriate biological material to use to evaluate biomarkers for peritoneal carcinomatosis.... -
- CITED
-
- Close
- SHARE
-
- Close
- Downregulation of SIRT2 by Chronic Stress Reduces Expression of Synaptic Plasticity-related Genes through the Upregulation of Ehmt2
-
Wang SE, Ko SY, Jo S, Jo HR, Han J, Kim YS, Son H
- KMID: 2458551
- Exp Neurobiol.
- 2019 Aug;28(4):537-546.
- doi: 10.5607/en.2019.28.4.537
Silent information regulator 2 (Sirtuin2 / SIRT2) is a NADâº-dependent deacetylase that regulates the cellular oxidative stress response. It modulates transcriptional silencing and protein stability through deacetylation of target proteins... -
- CITED
-
- Close
- SHARE
-
- Close
- Downregulation of IL-18 Expression in the Gut by Metformin-induced Gut Microbiota Modulation
-
Lee H, Kim J, An J, Lee S, Choi D, Kong H, Song Y, Park IH, Lee CK, Kim K
- KMID: 2455938
- Immune Netw.
- 2019 Aug;19(4):e28.
- doi: 10.4110/in.2019.19.e28
IL-18 is a crucial pro-inflammatory cytokine that mediates chronic intestinal inflammation. Metformin, an anti-diabetic drug, was reported to have ameliorative effects on inflammatory bowel disease. Recently, the mechanism of action... -
- CITED
-
- Close
- SHARE
-
- Close
- Targeted Downregulation of kdm4a Ameliorates Tau-engendered Defects in Drosophila melanogaster
-
Park SY, Seo J, Chun YS
- KMID: 2455488
- J Korean Med Sci.
- 2019 Aug;34(33):e225.
- doi: 10.3346/jkms.2019.34.e225
BACKGROUND: Tauopathies, a class of neurodegenerative diseases that includes Alzheimer's disease (AD), are characterized by the deposition of neurofibrillary tangles composed of hyperphosphorylated tau protein in the human brain. As... -
- CITED
-
- Close
- SHARE
-
- Close
- Long-term Surgical and Chemical Castration Deteriorates Memory Function Through Downregulation of PKA/CREB/BDNF and c-Raf/MEK/ERK Pathways in Hippocampus
-
Shin MS, Kim TW, Park SS, Ko IG, Kim CJ, Kim M, Roh SY, Kim KT, Kim KH
- KMID: 2452559
- Int Neurourol J.
- 2019 Jun;23(2):116-124.
- doi: 10.5213/inj.1938103.052
PURPOSE: Goserelin is a drug used for chemical castration. In a rat model, we investigated whether surgical and chemical castration affected memory ability through the protein kinase A (PKA)/cyclic adenosine... -
- CITED
-
- Close
- SHARE
-
- Close
- Early-Life Stress in D2 Heterozygous Mice Promotes Autistic-like Behaviors through the Downregulation of the BDNF-TrkB Pathway in the Dorsal Striatum
-
Lee Y, Han PL
- KMID: 2451070
- Exp Neurobiol.
- 2019 Jun;28(3):337-351.
- doi: 10.5607/en.2019.28.3.337
A number of specific genetic variants including gene mutations and single nucleotide variations have been identified in genomewide association studies of autism spectrum disorder (ASD). ASD phenotypes in individuals carrying... -
- CITED
-
- Close
- SHARE
-
- Close
- Colonic Transit Disorder Mediated by Downregulation of Interstitial Cells of Cajal/Anoctamin-1 in Dextran Sodium Sulfate-induced Colitis Mice
-
Lu C, Lu H, Huang X, Liu S, Zang J, Li Y, Chen J, Xu W
- KMID: 2449103
- J Neurogastroenterol Motil.
- 2019 Apr;25(2):316-331.
- doi: 10.5056/jnm18173
BACKGROUND/AIMS: Interstitial cells of Cajal (ICC) and their special calcium-activated chloride channel, anoctamin-1 (ANO1) play pivotal roles in regulating colonic transit. This study is designed to investigate the role of... -
- CITED
-
- Close
- SHARE
-
- Close
- TGF-β Signalling is Suppressed under Pro-Hypertrophic Conditions in MSC Chondrogenesis Due to TGF-β Receptor Downregulation
-
Pfeifer CG, Karl A, Kerschbaum M, Berner A, Lang S, Schupfner , Koch M, Angele P, Nerlich M, Mueller MB
- KMID: 2447232
- Int J Stem Cells.
- 2019 Mar;12(1):139-150.
- doi: 10.15283/ijsc18088
BACKGROUND AND OBJECTIVES: Mesenchymal stem cells (MSCs) become hypertrophic in long term despite chondrogenic differentiation following the pathway of growth plate chondrocytes. This terminal differentiation leads to phenotypically unstable cartilage... -
- CITED
-
- Close
- SHARE
-
- Close
- Mannosylerythritol lipids ameliorate ultraviolet A-induced aquaporin-3 downregulation by suppressing c-Jun N-terminal kinase phosphorylation in cultured human keratinocytes
-
Bae IH, Lee SH, Oh S, Choi H, Marinho PA, Yoo JW, Ko JY, Lee ES, Lee TR, Lee CS, Kim DY
- KMID: 2438085
- Korean J Physiol Pharmacol.
- 2019 Mar;23(2):113-120.
- doi: 10.4196/kjpp.2019.23.2.113
Mannosylerythritol lipids (MELs) are glycolipids and have several pharmacological efficacies. MELs also show skin-moisturizing efficacy through a yet-unknown underlying mechanism. Aquaporin-3 (AQP3) is a membrane protein that contributes to the... -
- CITED
-
- Close
- SHARE
-
- Close
- Effects of irradiation and leukoreduction on down-regulation of CXCL-8 and storage lesion in stored canine whole blood
-
Yang H, Kim W, Bae J, Kim H, Kim S, Choi J, Park J, Jung DI, Koh H, Yu D
- KMID: 2434780
- J Vet Sci.
- 2019 Jan;20(1):72-78.
- doi: 10.4142/jvs.2019.20.1.72
White blood cells (WBCs) and storage period are the main factors of transfusion reactions. In the present study, cytokine/chemokine concentrations after leukoreduction (LR) and irradiation (IR) in stored canine whole... -
- CITED
-
- Close
- SHARE
-
- Close
- Upregulation of long non-coding RNA XIST has anticancer effects on epithelial ovarian cancer cells through inverse downregulation of hsa-miR-214-3p
-
Wang C, Qi S, Xie C, Li C, Wang P, Liu D
- KMID: 2431244
- J Gynecol Oncol.
- 2018 Nov;29(6):e99.
- doi: 10.3802/jgo.2018.29.e99
OBJECTIVE: The present study is to evaluate the biological functions of long non-coding RNA (lncRNA), X-inactive specific transcript, X-inactive specific transcript (XIST) in human epithelial ovarian cancer (EOC). METHODS: XIST was... -
- CITED
-
- Close
- SHARE
-
- Close
- Beta-Catenin Downregulation Contributes to Epidermal Growth Factor-induced Migration and Invasion of MDAMB231 Cells
-
Kwon A, Park HJ, Baek JH
- KMID: 2437354
- Int J Oral Biol.
- 2018 Sep;43(3):161-169.
- doi: 10.11620/IJOB.2018.43.3.161
We previously demonstrated that epidermal growth factor (EGF) enhances cell migration and invasion of breast cancer cells in a SMAD ubiquitination regulatory factor 1 (SMURF1)-dependent manner and that SMURF1 induces... -
- CITED
-
- Close
- SHARE
-
- Close
- Down-regulation of transient receptor potential melastatin member 7 prevents migration and invasion of renal cell carcinoma cells via inactivation of the Src and Akt pathway
-
Ha YS, Kim YY, Yu NH, Chun SY, Choi SH, Lee JN, Kim BS, Yoo ES, Kwon TG
- KMID: 2414760
- Investig Clin Urol.
- 2018 Jul;59(4):263-274.
- doi: 10.4111/icu.2018.59.4.263
PURPOSE: Transient receptor potential melastatin member 7 (TRPM7), an ion channel and serine/threonine protein kinase, has been linked with distinct human malignancies. However, the role of TRPM7 in renal cell... -
- CITED
-
- Close
- SHARE
-
- Close
- Combined Effects of Baicalein and Docetaxel on Apoptosis in 8505c Anaplastic Thyroid Cancer Cells via Downregulation of the ERK and Akt/mTOR Pathways
-
Park CH, Han SE, Nam-Goong , Kim YI, Kim ES
- KMID: 2407129
- Endocrinol Metab.
- 2018 Mar;33(1):121-132.
- doi: 10.3803/EnM.2018.33.1.121
BACKGROUND: Anaplastic thyroid cancer (ATC) is one of the most lethal human malignancies. Docetaxel, a microtubule stabilizer, is a common chemotherapeutic agent used to treat various metastatic cancers. However, prolonged... -
- CITED
-
- Close
- SHARE
-
- Close
- Downregulation of HuR Inhibits the Progression of Esophageal Cancer through Interleukin-18
-
Xu X, Song C, Chen Z, Yu C, Wang Y, Tang Y, Luo J
- KMID: 2403476
- Cancer Res Treat.
- 2018 Jan;50(1):71-87.
- doi: 10.4143/crt.2017.013
PURPOSE: The purpose of this study was to investigate the effect of human antigen R (HuR) downregulation and the potential target genes of HuR on the progression of esophageal squamous... -
- CITED
-
- Close
- SHARE
-
- Close
- Carbon monoxide prevents TNF-α-induced eNOS downregulation by inhibiting NF-κB-responsive miR-155-5p biogenesis
-
Choi S, Kim J, Kim JH, Lee DK, Park W, Park M, Kim S, Hwang JY, Won MH, Choi YK, Ryoo S, Ha KS, Kwon YG, Kim YM
- KMID: 2396808
- Exp Mol Med.
- 2017 Nov;49(11):e403.
- doi: 10.1038/emm.2017.193
Heme oxygenase-1-derived carbon monoxide prevents inflammatory vascular disorders. To date, there is no clear evidence that HO-1/CO prevents endothelial dysfunction associated with the downregulation of endothelial NO synthesis in human... -
- CITED
-
- Close
- SHARE
-
- Close
- MPTP-induced vulnerability of dopamine neurons in A53T α-synuclein overexpressed mice with the potential involvement of DJ-1 downregulation
-
Lee S, Oh ST, Jeong HJ, Pak SC, Park HJ, Kim J, Cho HS, Jeon S
- KMID: 2395257
- Korean J Physiol Pharmacol.
- 2017 Nov;21(6):625-632.
- doi: 10.4196/kjpp.2017.21.6.625
Familial Parkinson's disease (PD) has been linked to point mutations and duplication of the α-synuclein (α-syn) gene. Mutant α-syn expression increases the vulnerability of neurons to exogenous insults. In this... -
- CITED
-
- Close
- SHARE
-
- Close
